Pressure injury in the perioperative period during COVID-19 pandemic: Incidence and patient-related risk factors in a hospital in Turkey

Şengül, Tuba; Gül, Asiye

doi:10.1016/j.jtv.2022.08.008

Cited by 3 publications

(1 citation statement)

References 33 publications

(79 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These methods are very effective and significantly reduce the occurrence of PIs [4]. However, for patients in the perioperative period, the above methods are difficult to implement due to the requirements of the surgical position and the surgical field of vision and the fact that many patients are unconscious after the use of anesthetics [5]. Therefore, the operating room is a high-incidence unit of PIs.…”

Section: Introductionmentioning

confidence: 99%

Topical Skin Application of Small-Molecule Antiplatelet Agent against Pressure Injury in Rat Models

Yuan,

Takashi,

Hou

et al. 2024

IJMS

View full text Add to dashboard Cite

Due to prolonged forced positioning, the incidence of intraoperative pressure injuries is high. This study aimed to explore the impact of small-molecule antiplatelet drugs on pressure injuries by locally applying them before an injury occurs. In the first part of this study, water-soluble tracers with different molecular weights were applied to normal and early-stage pressure-injured skin. Through digital cameras, spectrophotometers, and histological observations, the penetration of tracers into the epidermis was clarified. In the second part of this study, a water-soluble antiplatelet drug called Trapidil (molecular weight = 205 Da) was applied to the left side of the back of a rat before, during, and after compression, and the contralateral side served as a non-intervention control group. The differences in pressure injuries between the two groups were observed through a digital camera, an ultraviolet camera, and temperature measurement, and skin circulation and perfusion were assessed via an intravenous injection of Evans Blue. The first part of this study found that water-soluble tracers did not easily penetrate normal skin but could more easily penetrate pressure-damaged skin. The smaller the molecular weight of the tracer, the easier it penetrated the skin. Therefore, in the next step of research, water-soluble drugs with smaller molecular weights should be selected. The second part of this study found that, compared with the control group, the occurrence rates and areas of ulcers were lower, the gray value was higher, and the skin temperature was lower in the Trapidil group (p < 0.05). After the intravenous Evans Blue injection, skin circulation and perfusion in the Trapidil group were found to be better. In conclusion, this study found that the topical skin application of a small-molecule antiplatelet agent may have significant effects against pressure injuries by improving post-decompression ischemia, providing new insights into the prevention and treatment of intraoperative pressure injuries.

show abstract

Section: Introductionmentioning

confidence: 99%