2024
DOI: 10.1080/0886022x.2024.2384586
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Pressure induces peritoneal fibrosis and inflammation through CD44 signaling

Yu-Wei Chen,
Chia-Te Liao,
Mei-Yi Wu
et al.

Abstract: Peritoneal dialysis (PD) is a widely used sustainable kidney replacement therapy. Prolonged use of PD fluids is associated with mesothelial-mesenchymal transition, peritoneal fibrosis, and eventual ultrafiltration (UF) failure. However, the impact of pressure on the peritoneum remains unclear. In the present study, we hypothesized increased pressure is a potential contributing factor to peritoneal fibrosis and investigated the possible mechanisms. In vitro experiments found that pressuri… Show more

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