Pressure-induced formation of a solvate of paracetamol

Abstract

Recrystallisation of paracetamol from a solution in methanol at a pressure of 0.62 GPa gives a new 1:1 solvate that has been characterised by single crystal X-ray diffraction.

High-pressure diffraction studies of molecular organic solids. A personal view

“…At the same time, they can find important applications in molecular electronics and in the pharmaceutical industry (Boldyreva & Boldyrev, 1999;Shakhtshneider et al, 1999;Hemley & Dera, 2000;Boldyreva, Shakhtshneider et al, 2000;Katrusiak, 2001;Boldyreva, 2003a,b;Fabbiani et al, 2003Fabbiani et al, , 2004Boldyreva, Drebushchak, Paukov et al, 2004;Boldyreva, Drebushchak, Shakhtshneider, Ahsbahs, Uchtmann et al, 2004;Fabbiani, Allan, Marshall et al, 2005Fabbiani et al, 2006Fabbiani et al, , 2007Boldyreva, 2006Boldyreva, , 2007a.…”

“…Crystallization at high pressure has been known for a very long time, but its systematic application for obtaining new polymorphs and solvates started only a few years ago (Fabbiani et al, 2003(Fabbiani et al, , 2004Fabbiani, Allan, Marshall et al, 2005;Fabbiani et al, 2007). Some of the high-pressure polymorphs and solvates were never before observed at ambient conditions, also those forms that turned out to be quenchable to ambient pressure.…”

Multicomponent organic crystals at high pressure

“…Solvation -desolvation on compression and decompression is a promising topic that awaits a systematic research. The first examples of studies in this direction show already that high-pressure seems to favour the formation of solvates [63,[103][104][105][106][107][108][109], even of those compounds that were never obtained as solvates at ambient pressure, for example of L-alanine [63]. Very high degrees of hydration were reported for the high-pressure phases of some molecular compounds, such as GABA [107], or 1,4-diazabicyclo[2.2.2]octane hydroiodine [108].…”

Preparation and Evaluation of an Elusive Polymorph of Mefenamic Acid by High Pressure Techniques

“…This has successfully been used to generate new polymorphs of simple compounds e.g. new polymorphs of parabanic acid [8], urea [16], acetamide and paracetamol [8,17].…”