Pressure cycling technology:a novel approach to virus inactivation in plasma

Abstract

High-pressure procedures may be useful for the inactivation of viruses in blood and other protein-containing components.

Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection

“…A substantial literature has since accumulated on the use of pressure to inactivate a variety of bacterial, fungal, and viral pathogens (6). Generally speaking, the higher the pressure (and͞or temperature) the better the result, although a few notable exceptions have been observed, such as an optimal inactivation temperature near 0°C for Listeria (7) and phage (8).…”

Last Line to Secure Transfusion Safety: Pathogen Inactivation/Reduction Methods in Blood Products-Current Approaches and Perspectives

“…Under the illumination of 0.4 J/ cm 2 UVC, no bacterial growth was observed 6 days after treatment. Bradley et al investigated a pressure cycling technology derived from the industrial applications of food and vaccine PR to inactivate model pathogens in plasma [21]. With 2 minute cycles of 275 MPa or 345 MPa at -5°C, the phage titer of Lambda phage was reduced 4.2log or 6.9log, respectively.…”

Disinfection of Human Tissues in Orthopedic Surgical Oncology by High Hydrostatic Pressure

“…Inactivation of numerous viruses such as herpes viruses, rotaviruses, influenza, picornaviruses as well as immunodeficiency viruses by pressure treatment has been successful in blood (45,46). The use of high pressure in decreasing virus concentration in the blood of patients suffering severe virus infections by ex vivo pressure treatment of blood has been proposed (47), but studies on HHP inactivation of viruses present in bone, cartilage or tendon have not been reported yet.…”