Pressor Substance in the Cortex of the Kidney

The effect of renin on urine formation1

“…Evidence for efferent arteriolar constriction has previously been obtained in dogs anaesthetized with nembutal by Merrill et al [1938], who observed decreased renal blood flow and swelling of the kidney in response to renin. Friedman, Abramson & Marx [1938] in similar preparations observed a preliminary fall followed by a rise in kidney volume following renin injection.…”

The Etiology of Hypertension Due to Complete Renal Ischemia

“…The pressor effect of ischemic renal perfusate is not diminished or nullified by a previous injection of cocaine (five experiments). The pressor effect of renin is likewise not affected by a previous injection of cocaine (19,20), a substance which abolishes the pressor response of tyramine (21). 7. The following experiment is a more direct attempt to establish the identity of the pressor substance in ischemic renal perfusate with renin.…”

“…They termed this substance perfusin. Kohlstaedt, Helmer, and Page (25) and Friedman, Abramson, and Marx (20) showed that renin itself is not a pressor substance, and Page and Helmet (17) showed that renin incubated with plasma forms a heatstable substance which they termed angiotonin. Braun Menendez et al (18) independently made similar observations and termed this substance hypertensin.…”

Επιδραση Των Αναστολεων Του Ενζυμου Μετατροπης Της Αγγειοτασινης Στο Μεταβολισμο Του Μαγνησιου Και Του Ψευδαργυρου

“…ανακάλυψαν οτι η νεφρική ισχαιμία μπορούσε να προκαλέσει σοβαρή και μη αναστρέψιμη υπέρταση σε σκυλιά (23). Οι παρατηρήσεις των ερευνητών αυτών έδειξαν ότι η ρενίνη μπορεί να παίζει κάποιο σπουδαίο ρόλο στην υπέρταση και οδήγησαν στις μελέτες του Friedman το 1938 (24), που έδειξαν ότι η ίδια η ρενίνη…”