Pressor activity of renal venous effluent following constriction of renal artery in dogs

Abstract

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Pressor Activity of Circulating Blood After Focal Infarction of the Kidney in the Rat

“…The presently reported studies demonstrate that the acute hypertension which follows focal infarction of the kidney in the rat is accompanied by the appearance of a circulating pressor agent elaborated by the kidney which resembles in action that previously reported in the human ( 1 ) and in the dog ( 2 ) . Preoccupation with renin and angiotensin as renal pressor agents has led previous workers to assume that these agents mediated the acute elevation in blood pressure observed after drastic restriction of the renal artery.…”

“…As is the case in surgically remediable hypertension observed in man (1) and in acute hypertension induced by drastic restriction of the renal artery in the dog ( 2 ) and rat ( 3 ) , removal of the infarcted kidney is followed by an immediate decline in the elevated blood pressure to normal levels (12). I t differs in this respect from chronic hypertension induced by such procedures as moderate restriction of one renal artery or the application of a figure-of-eight ligature with ablation of the contralateral kidney which requires some weeks or months for its development.…”

“…In the acute hypertension which follows drastic restriction of a renal artery in man ( I ) , the dog ( 2 ) , and the rat (3) a pressor agent has been demonstrated to be present in the venous effluent from the affected kidney. This pressor agent has been variously considered to be renin, the concentration of which is increased in the renal venous effluent under these conditions (2) ; angiotensin, the pressor effect of which resembles that induced by the renal venous effluent (3) ; or an unidentified new pressor agent (1).…”

“…This pressor agent has been variously considered to be renin, the concentration of which is increased in the renal venous effluent under these conditions (2) ; angiotensin, the pressor effect of which resembles that induced by the renal venous effluent (3) ; or an unidentified new pressor agent (1). Focal infarction of the kidney is also followed by an acute rise in blood pressure which in the rat is not accompanied by an increase in renin secretion (4,5).…”

Bioassay in vivo for circulating vasoactive agents after renal artery constriction in dogs.

“…14 - 16 Our data for dogs pretreated with antirenin serum would support either conclusion. If the rise in systemic arterial pressure stimulated the release of prostaglandins, 14 l s this may help to account for the observed differences in the release of these substances by the two kidneys, because the increase in systemic pressure would have a greater effect on the untouched kidney than on the constricted kidney.…”