The world community has been changed irrevocably by the highly infectious and mutating SARS-CoV-2 virus that causes the COVID-19 disease. The necessary research output on COVID-19 has been revolutionary, especially in the medical and biomedical sciences, where the search for a vaccine is essential for the world to have a semblance of normality in the era of COVID-19. Much of the advanced research has been distributed in the leading medical journals, including the Journal of the American Medical Association (JAMA), where the latest medical research is distributed on a daily basis, and where comments can also be published. The purpose of this paper is to provide a critique of 110 interesting and highly topical research papers that have been published in JAMA, mostly within the past two months. The diverse topics include: treating influenza and COVID-19 simultaneously, dealing with a second wave of COVID-19 in Beijing, honesty is best for known and unknown GAWI and WIST, unreliability of asymptomatic COVID-19 testing outcomes for children, the effectiveness of flu vaccines, acute anxiety during COVID-19, MAID as an end of life option, longer-term effects of corticosteroids on the mortality of critically ill COVID-19 patients, isolation, loneliness and psychological distress during COVID-19, the selection of volunteers for COVID-19 vaccine trials, the mental health of children and adolescents during COVID-19, fertility preservation through hormonal intervention for transgender adolescents, safe, effective and affordable COVID-19 vaccines, essential requirements for acceptance of a COVID-19 vaccine, ischemic stroke rates from COVID-19 and influenza, mandatory COVID-19 vaccination of children, COVID-19 asymptomatic children and adults, Who Dares Wins (Qui Audet Adipiscitur), even against COVID-19, global health security index and responses to COVID-19, quality of life and dying, immunity from COVID-19, whom to trust or not to trust regarding COVID-19, the value of health care for cancer patients, previous medical research bodes well for a COVID-19 vaccine, you cannot fight COVID-19 alone, causality between hypertension and COVID-19, coffee consumption and metastatic colorectal cancer, improving statistical analysis of health policies on children and adolescents, COVID-19 does not respect anyone, politics diminishes the integrity and reputation of healthcare agencies, primary, secondary and tertiary cancers in the lung, health care should include everyone, especially for COVID-19, prioritizing access to COVID-19 vaccines, further questions about COVID-19 vaccines, estimating direct and indirect excess deaths from COVID-19, herd immunity for COVID-19, daily eyeglass wear and COVID-19 infection, using anything that prevents the spread of COVID-19, deferral of care for serious non-COVID-19 conditions, society's united fight against depression and suicide, the positive outcomes in delaying low-risk thyroid cancer treatment during COVID-19, the likely future toll from COVID-19, excluding older persons from vaccine and clinic...