Preshearing is an in situ setting modification method for inorganic bone cements

Şahin, Erdem; Kalyon, Dilhan M.

doi:10.1002/mds3.10105

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…At higher shear rates, i.e., at 10 –3 , 10 –2 , and 10 –1 s –1 , lower magnitudes and small dips in the viscosity can be seen, indicating retardation in the curing of the bone cement. This has also been observed for inorganic bone cements by Şahin and Kalyon . At 1 s –1 shear rate, the viscosity kept decreasing for almost the entire duration of the test.…”

Section: Resultssupporting

confidence: 76%

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Rheological Analysis and Evaluation of Measurement Techniques for Curing Poly(Methyl Methacrylate) Bone Cement in Vertebroplasty

Trivedi,

Wychowaniec,

Gehweiler

et al. 2024

ACS Biomater. Sci. Eng.

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Vertebroplasty is a minimally invasive surgical procedure used to treat vertebral fractures, which conventionally involves injecting poly(methyl methacrylate) (PMMA) bone cement into the fractured vertebra. A common risk associated with vertebroplasty is cement leaking out of the vertebra during the injection, which may occur due to a lack of understanding of the complex flow behavior. Therefore, experiments to quantify the cement's flow properties are necessary for understanding and proper handling of the bone cement. In this study, we aimed to characterize the behavior of PMMA bone cement in its curing stages to obtain parameters that govern the flow behavior during injection. We used rotational and oscillatory rheometry for our measurements, as well as a custom-made injector setup that replicated a typical vertebroplasty setting. Our results showed that the complex viscoelastic behavior of bone cement is significantly affected by deformations and temperature. We found that the results from rotational tests, often used for characterizing the bone cement, are susceptible to measurement artifacts caused by wall slip and "ridge"-like formations in the test sample. We also found the Cox−Merz rule to be conditionally valid, which affects the use of oscillatory tests to obtain the shear-thinning characteristics of bone cement. Our findings identify important differences in the measured flow behavior of PMMA bone cement when assessed by different rheological methods, an understanding that is crucial for its risk-free usage in downstream medical applications.

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Section: Resultssupporting

confidence: 76%

“…This has also been observed for inorganic bone cements by Sahin and Kalyon. 46 At 1 s −1 shear rate, the viscosity kept decreasing for almost the entire duration of the test. At 100 s −1 shear rate, the viscosity dropped almost entirely in the early stages (first 30 s) of the test.…”

Section: ■ Introductionmentioning

confidence: 90%

Rheological Analysis and Evaluation of Measurement Techniques for Curing Poly(Methyl Methacrylate) Bone Cement in Vertebroplasty

Trivedi,

Wychowaniec,

Gehweiler

et al. 2024

ACS Biomater. Sci. Eng.

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“…Important attraction mechanisms that drive gelation are generally short range, and include "van der Waals forces, surface chemistry, hydrophobic effects, and some depletion interactions" [4]. During the gelation process when macromolecules go from the sol phase to the gel phase, with various states of microgel formation, the linear viscoelastic properties are good reflections of the structural changes arising from the sol to gel transition [11,[16][17][18][19]. Fully formed gels can be highly elastic.…”

Section: Introduction 1gels and Gelationmentioning

confidence: 99%

Parallel-Disk Viscometry of a Viscoplastic Hydrogel: Yield Stress and Other Parameters of Shear Viscosity and Wall Slip

Kalyon

2022

Gels

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The rheology, i.e., the flow and deformation properties, of hydrogels is generally a very important consideration for their functionality. However, the accurate characterization of their rheological material functions is handicapped by their ubiquitous viscoplasticity and associated wall slip behavior. Here a parallel-disk viscometer was used to characterize the shear viscosity and wall slip behavior of a crosslinked poly(acrylic acid) (PAA) carbomer hydrogel (specifically Carbopol® at 0.12% by weight in water). It was demonstrated that parallel-disk viscometry, i.e., the steady torsional flow in between two parallel disks, can be used to unambiguously determine the yield stress and other parameters of viscoplastic constitutive equations and wall slip behavior. It was specifically shown that torque versus rotational speed information, obtained from parallel-disk viscometry, was sufficient to determine the yield stress of a viscoplastic hydrogel. Additional gap-dependent data from parallel-disk viscometry could then be used to characterize the other parameters of the shear viscosity and wall slip behavior of the hydrogel. To investigate the accuracy of the parameters of shear viscosity and apparent wall slip that were determined, the data were used to calculate the torque values and the velocity distributions (using the lubrication assumption and parallel plate analogy) under different flow conditions. The calculated torques and velocity distributions of the hydrogel agreed very well with experimental data collected by Medina-Bañuelos et al., 2021, suggesting that the methodologies demonstrated here provide the means necessary to understand in detail the steady flow and deformation behavior of hydrogels. Such a detailed understanding of the viscoplastic nature and wall slip behavior of hydrogels can then be used to design and develop novel hydrogels with a wider range of applications in the medical and other industrial areas, and for finding optimum conditions for their processing and manufacturing.

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Preshearing is an in situ setting modification method for inorganic bone cements

Cited by 2 publications

References 38 publications

Rheological Analysis and Evaluation of Measurement Techniques for Curing Poly(Methyl Methacrylate) Bone Cement in Vertebroplasty

Rheological Analysis and Evaluation of Measurement Techniques for Curing Poly(Methyl Methacrylate) Bone Cement in Vertebroplasty

Parallel-Disk Viscometry of a Viscoplastic Hydrogel: Yield Stress and Other Parameters of Shear Viscosity and Wall Slip

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