Preserving the Memories: Managing Dementia

Seitz, Dallas; Lee, Philip E.; Gill, Sudeep S.; Rochon, Paula A.

doi:10.1002/9781118281796.ch7

Cited by 1 publication

(1 citation statement)

References 142 publications

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“…It proposes that the deposition of Ab peptide is initial pathological event in AD leading to the formation of SPs and then to NFTs, neuronal cell death and ultimately dementia. In spite of its popularity, there are also limitations that first, SPs and NFTs may develop independently, and SPs and NFTs may be the products rather than causes of neurodegeneration [32].…”

Section: Amyloid Plaques and Amyloid Cascade Hypothesismentioning

confidence: 99%

Amyloid Cascade or Tau Dysfunction: The Cause for Alzheimer´s Disease

Vafaei

2015

JECNS

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Alzheimer´s Disease (AD) is an age-related neurodegenerative disorder which has yet to be fully understood. The amyloid cascade hypothesis (ACH) has played the prominent role in explaining the etiology and pathogenesis of AD. It proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to the formation of senile plaques (SPs) and then to neurofibrillary tangles (NFTs), neuronal cell death, and ultimately dementia. However, ACH has recently come under severe scrutiny as it has been claimed that SPs may be developed independently and might be the effect of the disease rather than the cause of AD. The present review indeed argues that the amyloid cascade is an effect of the disease and not the cause. We argue that excitotoxic processes caused by hyperphosphorylation of tau tangles at dendritic spines are the leading cause of the change in energy metabolism leading to apoptosis. We also propose that there are links among metabolism, the deposition of amyloid plaques, hyperphosphorylation of tau, and the decline of cognitive functions, following the increase of intraspinal cAMP that we claim is associated with decline of lactate.

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Section: Amyloid Plaques and Amyloid Cascade Hypothesismentioning

confidence: 99%

Amyloid Cascade or Tau Dysfunction: The Cause for Alzheimer´s Disease

Vafaei

2015

JECNS

View full text Add to dashboard Cite

show abstract

Preserving the Memories: Managing Dementia

Cited by 1 publication

References 142 publications

Amyloid Cascade or Tau Dysfunction: The Cause for Alzheimer´s Disease

Amyloid Cascade or Tau Dysfunction: The Cause for Alzheimer´s Disease

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