Preserved Vasopressin Response to Osmostimulation Despite Decreased Basal Vasopressin Levels in Long‐Term Abstinent Alcoholics

Jahn, Henriette; Döring, W.; Krampe, Henning; Sieg, Sonja; Werner, Carola; Poser, W.; Brunner, Edgar; Ehrenreich, Hannelore

doi:10.1097/01.alc.0000148110.34917.c3

Cited by 19 publications

(10 citation statements)

References 28 publications

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“…blood pressure, nicotine use). Only one of the articles acknowledged that the missing information was possibly relevant (Jahn et al, 2004) while another asserted that “plasma osmolality was not measured because it is not associated with plasma vasopressin in depression” (de Winter et al, 2003). Thus another implication of this work is that investigators should attend more closely to potential alterations in brain physiology in psychiatric disorders that may be linked to with well-characterized neural systems.…”

Section: Potential Significance Of Findings and Methodological Appmentioning

confidence: 99%

The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness

Goldman

2009

Brain Research Reviews

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Impaired water excretion was noted to coincide with psychotic exacerbations in the first decades of the past century. In the ensuing decades, life-threatening water intoxication and elevated plasma levels of the antidiuretic hormone, arginine vasopressin (AVP) were reported in a subset of persons with schizophrenia. Subsequent studies demonstrated that the osmotic set point for AVP secretion was transiently reset in these patients by an unknown process and that this was further exacerbated by acute psychosis. More recent studies indicate that the AVP dysfunction is a manifestation of a hippocampal-mediated impairment in the regulation of both AVP and HPA axis responses to psychological, but not other types of, stimuli. Of potential significance, is that schizophrenic patients without water imbalance exhibit the opposite pattern of responses. Preliminary data indicate those with water imbalance also demonstrate a closely linked deficit in central oxytocin activity which may account for their diminished social function. These latter behavioral deficits are perhaps the most disabling and treatment resistant features of schizophrenia, which recent studies suggest, may respond to oxytocin agonists. Together these findings support the view that schizophrenia is a heterogeneous disorder, and provide novel biomarkers and approaches for exploring the pathophysiology and treatment of severe mental illness.

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Section: Potential Significance Of Findings and Methodological Appmentioning

confidence: 99%

The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness

Goldman

2009

Brain Research Reviews

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“…In particular, plasma AVP was continuously suppressed in older healthy men as well as recently abstinent alcoholics anticipating novel stimuli, compared to healthy young men where AVP levels were significant increased (Ehrenreich et al 1997). This suppression in peripheral levels of AVP however, does not appear to affect the central AVP response to increased plasma osmolality in long-term abstinent alcoholics (Jahn et al 2004). …”

Section: Posterior Pituitary Hormonesmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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“…Polyuria causes polydipsia, which is excessive thirst. In the central nervous system, the decrement of AVP neurons in the hypothalamus in alcoholics is dose-related and time-dependent [100], [101], [102]. While the AVP response to osmotic stimulation is preserved, the plasma AVP level is decreased in alcoholics [102].…”

Section: Chronic Intake Of Etoh and Thirst Sensationmentioning

confidence: 99%

“…In the central nervous system, the decrement of AVP neurons in the hypothalamus in alcoholics is dose-related and time-dependent [100], [101], [102]. While the AVP response to osmotic stimulation is preserved, the plasma AVP level is decreased in alcoholics [102]. The volume of the SFO is increased; however, the volume of the area postrema, which is another circumventricular organ, is decreased in chronic EtOH treatment, whereas the number of cells in two brain regions is not changed in rodents [103].…”

Section: Chronic Intake Of Etoh and Thirst Sensationmentioning

confidence: 99%

Thirst sensation and oral dryness following alcohol intake

Inenaga

Ono

Hitomi

et al. 2017

Japanese Dental Science Review

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SummarySubstantial acute and chronic intakes of alcohol or ethanol (EtOH) severely influence oral sensations, such as thirst and oral dryness (dry mouth, xerostomia). Thirst sensation and oral dryness are primarily caused by the activation of neurons in brain regions, including the circumventricular organs and hypothalamus, which are referred to as the dipsogenic center, and by a decrease in salivary secretion, respectively. The sensation of thirst experienced after heavy-alcohol drinking is widely regarded as a consequence of EtOH-induced diuresis; however, EtOH in high doses induces anti-diuresis. Recently, it has been proposed that the ethanol metabolite acetaldehyde induces thirst via two distinct processes in the central nervous system from EtOH-induced diuresis, based on the results of animal experiments. The present review describes new insights regarding the induction mechanism of thirst sensation and oral dryness after drinking alcohol.

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Preserved Vasopressin Response to Osmostimulation Despite Decreased Basal Vasopressin Levels in Long‐Term Abstinent Alcoholics

Cited by 19 publications

References 28 publications

The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness

The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

Thirst sensation and oral dryness following alcohol intake

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