Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise

Soendenbroe, Casper; Dahl, Claus; Meulengracht, Christopher; Tamáš, Michal; Svensson, René B.; Schjerling, Peter; Kjær, Michael; Andersen, Jesper L.; Mackey, Abigail L.

doi:10.1113/jp282677

Cited by 19 publications

(30 citation statements)

References 90 publications

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“…Firstly, cheerleading involves many movements such as kicks, squats, and big jumps, and is beneficial for the growth of muscles ( Wisloff et al, 2004 ). Secondly, the large number of movement changes during the limited duration of cheerleading also helps to increase the neural control of muscles ( Soendenbroe et al, 2022 ). Thirdly, the complex movements involved in cheerleading also improve the ability of the participants to synergistically contract the various muscle groups.…”

Section: Discussionmentioning

confidence: 99%

Effects of cheerleading practice on advanced glycation end products, areal bone mineral density, and physical fitness in female adolescents

Wang

Zhang

et al. 2022

Front. Physiol.

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Background: Exercise has been widely reported to promote bone health, but it is unknown whether is associated with a reduction in advanced glycosylation end products (AGEs). This study aimed to investigate the effects of 14 weeks of cheerleading exercise on areal bone mineral density (aBMD) and AGEs.Methods: In this study, 46 female teenagers (age, 19.52 ± 1.21 years; body mass index, 20.15 ± 2.47 kg/m2) were randomly divided into a cheerleading group (CHE, n = 21) and a control group (CON, n = 25). The CHE group was subjected to cheerleading practice twice a week for 14 weeks; the CON group maintained their daily routine. Dual-energy X-ray absorptiometry was used to measure aBMD, and autofluorescence (AF) values were used to reflect AGEs. Physical fitness testing all-in-one machines are used to test body composition, cardiorespiratory fitness, muscle fitness and flexibility. A mixed ANOVA model was used to examine the effect of the intervention on each outcome. A multiple mediation model with covariates for physical activity and eating behaviors was performed to explore the mediators between cheerleading exercise and aBMD.Results: After 14 weeks of cheerleading practice, 1) aBMD increased significantly in both groups with significantly higher increases in the CHE group (p < 0.05). 2) AGEs significantly decreased in the CHE group (−2.7%), but not in the CON group (p > 0.05). 3) Vertical jumps and sit-ups significantly increased in the CHE group (p < 0.05), but not in the CON group (p > 0.05). 4) ΔAF values was significantly negatively correlated with Δ aBMD (r = −0.302, p < 0.05). 5) ΔAF values mediated the effect of exercise on the aBMD (indirect effect: 0.0032, 95% CI 0.0002–0.0079).Conclusion: Cheerleading practice improved aBMD and physical fitness and reduced AGEs accumulation in female adolescents. The effect of exercise on aBMD was partially mediated by AGEs.

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Section: Discussionmentioning

confidence: 99%

Effects of cheerleading practice on advanced glycation end products, areal bone mineral density, and physical fitness in female adolescents

Wang

Zhang

et al. 2022

Front. Physiol.

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“…Currently, lifestyle factors like diet and exercise are still the best protectors against age-related diseases. On this note, Dr. Casper Soendenbroe provided novel evidence that even physical activity performed at a recreational level offers some protection against the debilitating effects of ageing [ 59 ]. Specifically, lifelong exercising men had preserved levels of muscle stem cells and improved neuromuscular innervation, which culminated in a clinically relevant preservation of muscle function.…”

Section: Cardiovascular Cerebrovascular and Muscular Pathologies Of A...mentioning

confidence: 99%

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Schmauck-Medina

Molière

Lautrup

et al. 2022

Aging

Self Cite

168

103

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Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

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“…The work by Soendenbroe et al. (2022) conducted on males provides evidence that physically active older adults possess an innervation and satellite cell profile that is superior to sedentary older adults and comparable to young sedentary adults. Future research should build on these findings to further investigate the links between neuromuscular structure and function with physical activity into old age, particularly during high velocity contractions, and include female participants.…”

Section: Introductionmentioning

confidence: 99%

The benefits of physical activity on neuromuscular structure and function in old age

O’Bryan

Hiam

2022

The Journal of Physiology

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Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise

Abstract: support-information-section).

Cited by 19 publications

References 90 publications

Effects of cheerleading practice on advanced glycation end products, areal bone mineral density, and physical fitness in female adolescents

Effects of cheerleading practice on advanced glycation end products, areal bone mineral density, and physical fitness in female adolescents

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

The benefits of physical activity on neuromuscular structure and function in old age

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