Preserved motor memory in Parkinson's disease

Lahlou, Soraya; Gabitov, Ella; Owen, Lucy L. W.; Shohamy, Daphna; Sharp, Madeleine

doi:10.1016/j.neuropsychologia.2022.108161

Cited by 9 publications

(15 citation statements)

References 70 publications

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“…Our empirical findings and the meta-analysis highlight the challenge faced when using tasks as models of specific learning processes: Namely, that these tasks likely involve multiple learning processes and care must be taken to isolate the contribution of each process as well as the interaction between different processes (see also: (88)). To take one example, studies of the effect of PD on sequence learning have also yielded ambiguous results: A number of studies have reported deficits in sequence learning in PD (4,7,27), while other have reported no impairment (89–91). However, it has long been recognized that measures of sequence learning frequently involve the combined effects of implicit and explicit processes (92,93).…”

Section: Discussionmentioning

confidence: 99%

Implicit sensorimotor adaptation is preserved in Parkinson’s Disease

Najafi

Schuck

Wang

et al. 2022

Preprint

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Our ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in the body and environment. Whether Parkinson's Disease (PD) impacts implicit motor adaptation remains a contentious area of research: whereas multiple reports show impaired performance in this population, many others show intact performance. While there is a range of methodological differences across studies, one critical issue is that performance in many of the studies may reflect a combination of implicit adaptation and strategic re-aiming. Here, we revisited this controversy using a visuomotor task designed to isolate implicit adaptation. In two experiments, we found that adaptation in response to a wide range of visual perturbations (3° - 45°) was similar in PD and matched control participants. Moreover, in a meta-analysis of previously published work, we found that the mean effect size contrasting PD and controls across 16 experiments was not significant. Together, these analyses indicate that implicit adaptation is preserved in PD, offering a fresh perspective on the role of the basal ganglia in sensorimotor learning.

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Section: Discussionmentioning

confidence: 99%

Implicit sensorimotor adaptation is preserved in Parkinson’s Disease

Najafi

Schuck

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Disease severity, which was not reported in eight studies (Agostino et al, 2004;Lee et al, 2019;Leow et al, 2012;Mochizuki-Kawai et al, 2010;Nutt et al, 2000;Roy et al, 2015;Simley-Oyen et al, 2002;Smiley-Oyen et al, 2003), ranged from I to IV on the Hoehn & Yahr scale. The mean overall scores of the motor evaluation conducted with the UPDRS part III, which was reported in 22 studies (Agostino et al, 2004;Dan et al, 2015;Isaias et al, 2011;Kawashima et al, 2018;Lahlou et al, 2022;Lee et al, 2019;Leow et al, 2012;Lin et al, 2007;Marinelli et al, 2017b;Nackaerts et al, 2020;Nelson et al, 2017;Nicastro et al, 2018;Pendt et al, 2012;Pendt et al, 2011;Peterson et al, 2016;Roy et al, 2015;Sehm et al, 2014;Sidaway et al, 2016;Van Ooteghem et al, 2017;Whitfield and Goberman, 2017), ranged from 8 to 33.4, indicating that the severity of motor symptoms of patients ranged from mild to moderate (Hentz et al, 2015;Martínez-Martín et al, 2015). Disease duration, which was reported in all but seven studies (Dantas et al, 2018;Marinelli et al, 2017b;Mochizuki-Kawai et al, 2010;Sato et al, 2014;Sidaway et al, 2016;Simley-Oyen et al, 2002;Smiley-Oyen et al, 2003)…”

Section: Characteristics Of the Studiesmentioning

confidence: 95%

“…After identifying 45 studies, one additional study (Nutt et al, 2000) found in the reference list of studies reviewed was added. The review included a total of 46 studies but since it was not possible to obtain means and SDs from six studies (Doyon et al, 1998;Gawrys et al, 2008;Isaias et al, 2011;Nutt et al, 2000;ThomasAnterion et al, 1996;Werheid et al, 2003), whose results are reported qualitatively, the meta-analyses included 40 studies (Agostino et al, 2004;Behrman et al, 2000;Dan et al, 2015;Dantas et al, 2018;Foreman et al, 2013;Hadj-Bouziane et al, 2013;Harrington et al, 1990;Jessop et al, 2006;Kawashima et al, 2018;Lahlou et al, 2022;Lee et al, 2016;Lee and Fisher, 2018;Lee et al, 2019;Leow et al, 2012;Lin et al, 2007;Marinelli et al, 2017b;Mochizuki-Kawai et al, 2010;Nackaerts et al, 2020;Nelson et al, 2017;Nicastro et al, 2018;Onla-Or and Winstein, 2008;Pendt et al, 2012;Pendt et al, 2011;Peterson et al, 2016;Platz et al, 1998;Roy et al, 2015;Sato et al, 2014;Sehm et al, 2014;Sidaway et al, 2016;Simley-Oyen et al, 2002;Smiley-Oyen et al, 2012;Smiley-Oyen et al, 2006;…”

Section: Articles Retrievedmentioning

confidence: 99%

“…Disease duration, which was reported in all but seven studies (Dantas et al, 2018;Marinelli et al, 2017b;Mochizuki-Kawai et al, 2010;Sato et al, 2014;Sidaway et al, 2016;Simley-Oyen et al, 2002;Smiley-Oyen et al, 2003), ranged from 1.3 to 11.1 years. Only three investigations (Hadj-Bouziane et al, 2013;Lahlou et al, 2022) manipulated (e.g., compared "on" vs. "off") medication status, while two studies (Kawashima et al, 2018;Platz et al, 1998) tested patients "off" medication (Table 2). Six studies did not report and/or evaluate cognitive functioning (Foreman et al, 2013;Hadj-Bouziane et al, 2013;Jessop et al, 2006;Nelson et al, 2017;Nutt et al, 2000;Van Ooteghem et al, 2017).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Forty studies (Agostino et al, 2004;Dan et al, 2015;Doyon et al, 1998;Foreman et al, 2013;Gawrys et al, 2008;Hadj-Bouziane et al, 2013;Harrington et al, 1990;Isaias et al, 2011;Jessop et al, 2006;Kawashima et al, 2018;Lahlou et al, 2022;Lee et al, 2016;Lee and Fisher, 2018;Lee et al, 2019;Leow et al, 2012;Lin et al, 2007;Marinelli et al, 2009;Marinelli et al, 2017b;Mochizuki-Kawai et al, 2010;Nackaerts et al, 2020;Nelson et al, 2017;Nicastro et al, 2018;Onla-Or and Winstein, 2008;Pendt et al, 2011;Peterson et al, 2016;Platz et al, 1998;Roy et al, 2015;Sehm et al, 2014;Sidaway et al, 2016;Simley-Oyen et al, 2002;Swinnen et al, 2000;Terpening et al, 2013;ThomasAnterion et al, 1996;Van Ooteghem et al, 2017;Werheid et al, 2003;Whitfield and Goberman, 2017) assessed retention after a single session of practice, while 14 studies (Agostino et al, 2004;Behrman et al, 2000;Dantas et al, 2018;…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Motor Skill Retention Impairments in Parkinson’s Disease: A Systematic Review with Meta-analysis

Cristini

Parwanta

Heras

et al. 2022

Preprint

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The ability to acquire and retain motor skills is essential for persons with Parkinson's Disease (PD), who usually experience a progressive loss of mobility during the disease. Deficits in the rate of motor skill acquisition have been previously reported in these patients. Whether motor skill retention is also impaired is currently not known. We conducted a review that included 46 studies to determine whether, compared with neurologically intact individuals, motor skill retention is impaired in PD. Meta-analyses revealed that, following a single practice session, persons with PD have deficits in skill retention (SMD = -0.17; 95% CI = -0.32, -0.02; p = 0.0225). However, these deficits are task-specific, affecting sensory motor (SMD = -0.31; 95% CI -0.47, -0.15; p = 0.0002) and visuomotor adaptation (SMD = -1.55; 95% CI = -2.32, -0.79; p = 0.0001) tasks, but not sequential fine motor (SMD = 0.17; 95% CI = -0.05, 0.39; p = 0.1292) and gross motor tasks (SMD = 0.04; 95% CI = -0.25, 0.33; p = 0.7771). Importantly, retention deficits became non-significant when augmented feedback during practice was provided. Similarly, additional sessions of motor practice restored the deficits observed in sensory motor tasks. Meta-regression analyses confirmed that retention deficits were independent of performance during motor skill acquisition, as well as the duration and severity of the disease. These results are in line with prominent neurodegenerative models of PD progression and emphasize the importance of developing targeted interventions to enhance motor memory processes supporting the retention of motor skills in people with PD.

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Implicit sensorimotor adaptation is preserved in Parkinson’s disease

Najafi

Schuck

Wang

et al. 2022

Brain Communications

View full text Add to dashboard Cite

Our ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in the body and environment. Whether Parkinson’s disease impacts implicit motor adaptation remains a contentious area of research: whereas multiple reports show impaired performance in this population, many others show intact performance. While there is a range of methodological differences across studies, one critical issue is that performance in many of the studies may reflect a combination of implicit adaptation and strategic re-aiming. Here, we revisited this controversy using a visuomotor task designed to isolate implicit adaptation. In two experiments, we found that adaptation in response to a wide range of visual perturbations was similar in Parkinson’s disease and matched control participants. Moreover, in a meta-analysis of previously published and unpublished work, we found that the mean effect size contrasting Parkinson’s disease and controls across 16 experiments involving over 200 participants was not significant. Together, these analyses indicate that implicit adaptation is preserved in Parkinson’s disease, offering a fresh perspective on the role of the basal ganglia in sensorimotor learning.

show abstract

Preserved motor memory in Parkinson's disease

Cited by 9 publications

References 70 publications

Implicit sensorimotor adaptation is preserved in Parkinson’s Disease

Implicit sensorimotor adaptation is preserved in Parkinson’s Disease

Motor Skill Retention Impairments in Parkinson’s Disease: A Systematic Review with Meta-analysis

Implicit sensorimotor adaptation is preserved in Parkinson’s disease

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