Preserved microstructural integrity of the corticospinal tract in patients with glioma-induced motor epilepsy: a study using mean apparent propagator magnetic resonance imaging

Wang, Yuhui; Deng, Kaiji; Sun, Yifan; Huang, Xin; Dai, Yihai; Chen, Weitao; Hu, Xiaomei; Jiang, Rifeng

doi:10.21037/qims-21-679

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…Further, when the subcortical structure containing the potential epicenter is damaged, the discharge tends to be isolated and less likely to form a generalized seizure. Besides, a previous study also demonstrated that the integrity of the ipsilateral CST is well preserved in glioma patients with motor epilepsy 43 . Together with the current result, we assumed that the preserved microstructural integrity of the bilateral CST may be potential mechanisms underlying the generation and development of GRE.…”

Section: Discussionsupporting

confidence: 85%

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Multiparametric mapping of white matter reorganizations in patients with frontal glioma‐related epilepsy

et al. 2023

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Aims: Epilepsy is a common symptom in diffuse lower-grade glioma (DLGG). The specific role of white matter (WM) alteration in patients with glioma-related epilepsy (GRE) is largely unknown. This study aims to investigate the reorganization of WM tracts and changes in structural networks related to GRE. Methods: Diffusion-weighted images were collected from 70 patients with left frontal DLGG (GRE = 33, non-GRE = 37) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups. Results: Compared with HC, both GRE and non-GRE showed decreased FA in contralateral inferior fronto-occipital fasciculus, superior longitudinal fasciculus II and arcuate fasciculus, increased nodal efficiency in contralateral nodes of frontal-parietal and limbic networks, whereas decreased degree centrality and betweenness centrality in nodes of dorsal temporal lobe and rostral middle frontal gyrus (rMFG). Additionally, when compared GRE with non-GRE, increased FA in contralateral corticospinal tract (CST) and lower betweenness centrality in paracentral lobule (PCL) in GRE (all p < 0.05 after Bonferroni correction). Conclusion: This study indicates that patients with left frontal DLGG exhibit complex WM reorganization, and the altered regions mainly concentrated in the language, frontal-parietal and limbic networks. Moreover, the preserved integrity in | 2367 ZHANG et al.

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Section: Discussionsupporting

confidence: 85%

“…Besides, a previous study also demonstrated that the integrity of the ipsilateral CST is well preserved in glioma patients with motor epilepsy. 43 Together with the current result, we assumed that the preserved microstructural integrity of the bilateral CST may be potential mechanisms underlying the generation and development of GRE.…”

Section: Discussionsupporting

confidence: 74%

Multiparametric mapping of white matter reorganizations in patients with frontal glioma‐related epilepsy

et al. 2023

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“…MAP-MRI metrics have been shown to be sensitive to microstructural changes in brain tissues in various neurological conditions and neurodevelopment (Bouhrara et al, 2022;C.-L. Chen, Shih, et al, 2019;H.-J. Chen et al, 2021;Le et al, 2020;Ma et al, 2020;Moody et al, 2022;Mustafi et al, 2019;Pines et al, 2020;Qiu et al, 2022;Sun et al, 2022;Wang, He, et al, 2022;Wang, Deng, et al, 2022;Xie et al, 2022), with one study documenting an association between RTOP and clinical measures in mTBI patients assessed within 15 days of injury (Y.-C. Wu et al, 2018). To our knowledge, however, no prior work has applied the MAP-MRI technique to investigate the longterm effects of concussion.…”

Section: Introductionmentioning

confidence: 99%

“…Chen, Shih, et al, 2019 ; H.‐J. Chen et al, 2021 ; Le et al, 2020 ; Ma et al, 2020 ; Moody et al, 2022 ; Mustafi et al, 2019 ; Pines et al, 2020 ; Qiu et al, 2022 ; Sun et al, 2022 ; Wang, Gao, et al, 2022 ; Wang, He, et al, 2022 ; Wang, Deng, et al, 2022 ; Xie et al, 2022 ), with one study documenting an association between RTOP and clinical measures in mTBI patients assessed within 15 days of injury (Y.‐C. Wu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Associations of prior concussion severity with brain microstructure using mean apparent propagator magnetic resonance imaging

Goeckner,

Brett,

Mayer

et al. 2023

Human Brain Mapping

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Magnetic resonance imaging (MRI) diffusion studies have shown chronic microstructural tissue abnormalities in athletes with history of concussion, but with inconsistent findings. Concussions with post‐traumatic amnesia (PTA) and/or loss of consciousness (LOC) have been connected to greater physiological injury. The novel mean apparent propagator (MAP) MRI is expected to be more sensitive to such tissue injury than the conventional diffusion tensor imaging. This study examined effects of prior concussion severity on microstructure with MAP‐MRI. Collegiate‐aged athletes (N = 111, 38 females; ≥6 months since most recent concussion, if present) completed semistructured interviews to determine the presence of prior concussion and associated injury characteristics, including PTA and LOC. MAP‐MRI metrics (mean non‐Gaussian diffusion [NG Mean], return‐to‐origin probability [RTOP], and mean square displacement [MSD]) were calculated from multi‐shell diffusion data, then evaluated for associations with concussion severity through group comparisons in a primary model (athletes with/without prior concussion) and two secondary models (athletes with/without prior concussion with PTA and/or LOC, and athletes with/without prior concussion with LOC only). Bayesian multilevel modeling estimated models in regions of interest (ROI) in white matter and subcortical gray matter, separately. In gray matter, the primary model showed decreased NG Mean and RTOP in the bilateral pallidum and decreased NG Mean in the left putamen with prior concussion. In white matter, lower NG Mean with prior concussion was present in all ROI across all models and was further decreased with LOC. However, only prior concussion with LOC was associated with decreased RTOP and increased MSD across ROI. Exploratory analyses conducted separately in male and female athletes indicate associations in the primary model may differ by sex. Results suggest microstructural measures in gray matter are associated with a general history of concussion, while a severity‐dependent association of prior concussion may exist in white matter.

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“…Recently, Saleem et al ( 2021 ) validated the measures derived from high-resolution MAP-MRI via comparisons with histology data from the macaque brain. MAP-MRI was also successfully used in detecting changes induced by stroke (Boscolo Galazzo et al, 2018 ), Parkinson's disease (PD) (Le et al, 2020 ) and in distinguishing the grades of gliomas (Wang et al, 2021 ; Sun et al, 2022 ), comparing the microstructural integrity of the corticospinal tract (CST) between glioma patients with and without motor epilepsy (Wang et al, 2022 ) and detecting amyotrophic lateral sclerosis (ALS)-related white matter (WM) alterations (Chen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Cumulant expansion with localization: A new representation of the diffusion MRI signal

Afzali

Pieciak

Jones

et al. 2022

Front. Neuroimaging

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Diffusion MR is sensitive to the microstructural features of a sample. Fine-scale characteristics can be probed by employing strong diffusion gradients while the low b-value regime is determined by the cumulants of the distribution of particle displacements. A signal representation based on the cumulants, however, suffers from a finite convergence radius and cannot represent the ‘localization regime' characterized by a stretched exponential decay that emerges at large gradient strengths. Here, we propose a new representation for the diffusion MR signal. Our method provides not only a robust estimate of the first three cumulants but also a meaningful extrapolation of the entire signal decay.

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Preserved microstructural integrity of the corticospinal tract in patients with glioma-induced motor epilepsy: a study using mean apparent propagator magnetic resonance imaging

Cited by 4 publications

References 31 publications

Multiparametric mapping of white matter reorganizations in patients with frontal glioma‐related epilepsy

Multiparametric mapping of white matter reorganizations in patients with frontal glioma‐related epilepsy

Associations of prior concussion severity with brain microstructure using mean apparent propagator magnetic resonance imaging

Cumulant expansion with localization: A new representation of the diffusion MRI signal

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