Preserved memory capacities in aged Lou/C/Jall rats

Kollen, Mélanie; Stéphan, Aline; Faivre-Bauman, A.; Loudes, C.; Sinet, Pierre-Marie; Alliot, Josette; Billard, Jean‐Marie; Epelbaum, Jacques; Dutar, P.; Jouvenceau, Anne

doi:10.1016/j.neurobiolaging.2008.03.010

Cited by 41 publications

(48 citation statements)

References 80 publications

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“…No differences in PFV slopes were found between the two groups of animals, whereas fEPSP slopes were significantly reduced (Fig. S1), as previously described [see (Potier et al, 2000;Kollen et al, 2010)]. When applied at a concentration of 25 lM, DL-TBOA slightly but nonsignificantly reduced fEPSPs in young rats (n = 15 slices in 10 animals) at all stimulus intensities (Fig.…”

Section: Effect Of Dl-tboa On Basal Synaptic Transmissionsupporting

confidence: 86%

“…This is in contrast to other forms of LTD that can be easily obtained in young rats by straightforward activation of NMDAR, such as chemical LTD (Kollen et al, 2008). Chemical LTD is an APV-sensitive form of LTD that involves synaptic but also extrasynaptic NMDA receptors (Kollen et al, 2010). Chemical LTD is artificially obtained by bath application of low doses of NMDA, an exogenous agonist not transported by glutamate transporters, conversely to endogenous glutamate used in this study.…”

Section: Discussionmentioning

confidence: 96%

“…The expression of the AMPAR subtype of glutamate receptors is unaffected, despite weakened AMPAR-mediated transmission (Potier et al, 2000;Kollen et al, 2008). However, aging is associated with the alteration of N-Methyl-D-Aspartate receptor (NMDAR) expression (Sonntag et al, 2000;Wenk & Barnes, 2000;Clayton & Browning, 2001;Shi et al, 2007;Kollen et al, 2010) and function (Barnes et al, 1997;Billard et al, 1997;Jouvenceau et al, 1998;Potier et al, 2000;Magnusson et al, 2007;Boric et al, 2008). These alterations contribute to the age-related decline in spatial learning [see Rosenzweig & Barnes (2003) for review].…”

Section: Introductionmentioning

confidence: 99%

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Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

et al. 2010

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SummaryThis study aims to determine whether the regulation of extracellular glutamate is altered during aging and its possible consequences on synaptic transmission and plasticity. A decrease in the expression of the glial glutamate transporters GLAST and GLT-1 and reduced glutamate uptake occur in the aged (24-27 months) SpragueDawley rat hippocampus. Glutamatergic excitatory postsynaptic potentials recorded extracellularly in ex vivo hippocampal slices from adult (3-5 months) and aged rats are depressed by DL-TBOA, an inhibitor of glutamate transporter activity, in an N-Methyl-D-Aspartate (NMDA)-receptor-dependent manner. In aged but not in young rats, part of the depressing effect of DL-TBOA also involves metabotropic glutamate receptor (mGluRs) activation as it is significantly reduced by the specific mGluR antagonist d-methyl-4-carboxy-phenylglycine (MCPG). The paired-pulse facilitation ratio, a functional index of glutamate release, is reduced by MCPG in aged slices to a level comparable to that in young rats both under control conditions and after being enhanced by DL-TBOA. These results suggest that the age-associated glutamate uptake deficiency favors presynaptic mGluR activation that lowers glutamate release. In parallel, 2 Hz-induced long-term depression is significantly decreased in aged animals and is fully restored by MCPG. All these data indicate a facilitated activation of extrasynaptic NMDAR and mGluRs in aged rats, possibly because of an altered distribution of glutamate in the extrasynaptic space. This in turn affects synaptic transmission and plasticity within the aged hippocampal CA1 network.

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Section: Effect Of Dl-tboa On Basal Synaptic Transmissionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

et al. 2010

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“…We are particularly interested in the LOU/C-inbred rat strain, which was derived from the Wistar strain and has been described as a model of healthy ageing with a long life expectancy and preserved memory capacities (Kollen et al 2010). This strain was shown not only to be lean but also to be resistant to age-and diet-induced obesity , Marissal-Arvy et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Vitamin A regulates hypothalamic–pituitary–adrenal axis status in LOU/C rats

Marissal-Arvy¹,

Hamiani²,

Richard³

et al. 2013

Journal of Endocrinology

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The aim of this study was to explore the involvement of retinoids in the hypoactivity and hyporeactivity to stress of the hypothalamic-pituitary-adrenal (HPA) axis in LOU/C rats. We measured the effects of vitamin A deficiency administered or not with retinoic acid (RA) on plasma corticosterone in standard conditions and in response to restraint stress and on hypothalamic and hippocampal expression of corticosteroid receptors, corticotropinreleasing hormone and 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) in LOU/C rats. Interestingly, under control conditions, we measured a higher plasma concentration of retinol in LOU/C than in Wistar rats, which could contribute to the lower basal activity of the HPA axis in LOU/C rats. Vitamin A deficiency induced an increased HPA axis activity in LOU/C rats, normalized by RA administration. Compared with LOU/C control rats, vitamin A-deficient rats showed a delayed and heightened corticosterone response to restraint stress. The expression of corticosteroid receptors was strongly decreased by vitamin A deficiency in the hippocampus, which could contribute to a less efficient feedback by corticosterone on HPA axis tone. The expression of 11b-HSD1 was increased by vitamin A deficiency in the hypothalamus (C62.5%) as in the hippocampus (C104.7%), which could lead to a higher production of corticosterone locally and contribute to alteration of the hippocampus. RA supplementation treatment restored corticosterone concentrations and 11b-HSD1 expression to control levels. The high vitamin A status of LOU/C rats could contribute to their low HPA axis activity/reactivity and to a protective effect against 11b-HSD1-mediated deleterious action on cognitive performances during ageing.

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“…Indeed, middle-aged biological systems are particularly sensitive to toxicological factors, as shown by exacerbated behavioral impairments in middle-aged animals, when compared to younger animals, in response to lipopolysaccharide administration and traumatic brain injury (Hoane et al, 2004;Kohman et al, 2010). In addition, enrichment or self food-restriction diet during middle-age may postpone the appearance of age-related memory decline and neurochemical modifications (Frick et al, 2003;Kollen et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Bouji¹,

Lecomte²,

Hode³

et al. 2012

Experimental Gerontology

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. Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats. Experimental Gerontology, Elsevier, 2012, 47 (6) ABSTRACTThe widespread use of mobile phones raises the question of the effects of electromagnetic fields (EMF, 900 MHz) on the brain. Previous studies reported increased levels of the glial fibrillary acidic protein (GFAP) in the rat's brain after a single exposure to 900 MHz global system for mobile (GSM) signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available in older animals. Since the transition from middle-age to senescence is highly dependent on environment and lifestyle, we studied the reactivity of middle-aged brains to EMF exposure. We assessed the effects of a single 15 min GSM exposure (900MHz; specific absorption rate (SAR) = 6 W/kg) on GFAP expression in young adults (6 week-old) and middle-aged rats (12 month-old). Brain interleukin (IL)-1β and IL-6, plasmatic levels of corticosterone (CORT), and emotional memory were also assessed.Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce astrocytes activation. Our results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, and increased plasmatic levels of CORT in GSM-exposed young adults. Altogether, our data showed an age dependency of reactivity to GSM exposure in neuroimmunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.

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Preserved memory capacities in aged Lou/C/Jall rats

Cited by 41 publications

References 80 publications

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

Vitamin A regulates hypothalamic–pituitary–adrenal axis status in LOU/C rats

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

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