Preserved extracellular matrix components and retained biological activity in decellularized porcine mesothelium

Hoganson, David M.; Owens, Gwen E.; O’Doherty, Elisabeth M.; Bowley, Chris M.; Goldman, Scott; Harilal, Dina O.; Neville, Craig M.; Kronengold, Russell T.; Vacanti, Joseph P.

doi:10.1016/j.biomaterials.2010.05.026

Cited by 79 publications

(68 citation statements)

References 41 publications

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“…Growth factors are bioactive molecules responsible for the activation of a plethora of cellular pathways that modulate cell survival, proliferation, and differentiation. The presence of vascular endothelial growth factor (VEGF) (Wang et al 2013b), fibroblast growth factor (FGF) family (Hoganson et al 2010), epidermal growth factor (EGF), transforming growth factor b (TGF-b), keratinocyte growth factor (KGF), hepatocyte growth factor (HGF) (Soto-Gutierrez et al 2011;Ren et al 2013), platelet-derived growth factor (PDGF), and nerve growth factor (NGF), among others, within ECM bioscaffolds has been shown (Meezan et al 1975;Bissell et al 1982;Gilbert et al 2006;Badylak et al 2008a;Crapo et al 2012;Wolf et al 2012). …”

Section: Production Of Ecm Bioscaffolds Extracellular Matrix Compositmentioning

confidence: 99%

Biologic Scaffolds

Costa

Naranjo

Londoño

et al. 2017

Cold Spring Harb Perspect Med

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Section: Production Of Ecm Bioscaffolds Extracellular Matrix Compositmentioning

confidence: 99%

Biologic Scaffolds

Costa

Naranjo

Londoño

et al. 2017

Cold Spring Harb Perspect Med

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“…The multi-molecular properties of tissue derived ECM gives these naturally derived biomaterials a level of complexity and remodelability not observed with synthetic materials [14, 15]. In fact, significant research effort has been focused on mimicking the properties of ECM in synthetics [16–18], suggesting recognition of the important role of ECM molecules during the wound healing process.…”

Section: Introductionmentioning

confidence: 99%

Development of a biological scaffold engineered using the extracellular matrix secreted by skeletal muscle cells

Hurd¹,

Bhatti²,

Walker³

et al. 2015

Biomaterials

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The performance of implantable biomaterials derived from decellularized tissue, including encouraging results with skeletal muscle, suggests that the extracellular matrix (ECM) derived from native tissue has promising regenerative potential. Yet, the supply of biomaterials derived from donated tissue will always be limited, which is why the in-vitro fabrication of ECM biomaterials that mimic the properties of tissue is an attractive alternative. Towards this end, our group has utilized a novel method to collect the ECM that skeletal muscle myoblasts secrete and form it into implantable scaffolds. The cell derived ECM contained several matrix constituents, including collagen and fibronectin that were also identified within skeletal muscle samples. The ECM was organized into a porous network that could be formed with the elongated and aligned architecture observed within muscle samples. The ECM material supported the attachment and in-vitro proliferation of cells, suggesting effectiveness for cell transplantation, and was well tolerated by the host when examined in-vivo. The results suggest that the ECM collection approach can be used to produce biomaterials with compositions and structures that are similar to muscle samples, and while the physical properties may not yet match muscle values, the in-vitro and in-vivo results indicate it may be a suitable first generation alternative to tissue derived biomaterials.

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“…For example, decellularized 70 porcine small intestinal submucosa (SIS) material has been com- 71 mercialized and clinically used for skeletal muscle treatment 72 [15]. Furthermore, decellularized materials as tissue-specific scaf- 73 folds show great promise in repairing and regenerating specific tis- 74 sues and organs [16]. Among these, the implantation of heart-75 derived ECM material into an infarcted heart has been shown to 76 promote endogenous cardiomyocyte recruitment and restore heart 77 functions [17,18].…”

mentioning

confidence: 99%