Preserved Bone Allografts in Reconstructive Orthopaedics

Komender, J; Komender, A; Malczewska, Hanna; Marczyński, Wojciech

doi:10.1142/9789812701114_0002

Cited by 8 publications

(9 citation statements)

References 6 publications

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“…Pasteurization of bone grafts (Rosen et al 2000) and 70 % ethanol soaks (Rosen et al 2000) have been shown to kill viruses, while freeze-drying in addition to increasing the shelf life of the graft and reducing its antigenicity, also reduces the risk of disease transfer (Rosen et al 2000). Gamma radiation is a well accepted method of sterilization and does not affect the physical and biological properties of tissue allografts (Dziedzic-Goclawska et al 2005;Komender et al 2001). Clinically, however, some studies indicate Cell Tissue Bank that radiation-sterilized grafts show reduced mechanical durability and an increased tendency to resorption (Eastlund 2005(Eastlund , 2006.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects

et al. 2014

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Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. Questions have been raised however, about the osteogenic potential of the variety of grafts available. In India the cost factor is another important consideration. The aim of this study therefore was to evaluate the clinical efficiency of the low priced, indigenously prepared DFDBA obtained from the Tata Memorial Hospital (TMH) Tissue Bank, in periodontal regeneration in infrabony periodontal defects, as compared to DFDBA obtained from the Pacific Coast Tissue Bank (DEMBONE). The latter was used as the control. 16 patients with bilaterally similar periodontal infrabony defects were selected, and randomly allotted to the test and control groups. At baseline, using standardized protocol, recession, probing depths (PD), and clinical attachment levels (CAL) were measured, following which periodontal surgery was carried out, with placement of the respective graft materials. Patients were recalled after 6 months for re-assessment. Statistically significant improvement was obtained for PD reduction and CAL gain for both groups (p < 0.05). However, no significant difference was observed between the test and control groups. It was therefore concluded that both the materials from different tissue banks are equally effective clinically, with the test material being additionally cost effective.

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Section: Discussionmentioning

confidence: 99%

Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects

et al. 2014

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“…41 In experimental models, among the methods of allogenic bone preparation for flap prefabrication, the frozen process alone did not alter the osteoinductive capacity probably because it does preserve osteoinductive proteins such as BMPs. 42,43 In contrast, demineralization and lyophilization reduce the mechanical strength of these bone fragments. 17 Thus, the use of prepared (demineralized\ lyophilized) allogenic bone would be contraindicated in places where there is mechanical load, such as the mandible and lower limbs.…”

Section: Discussionmentioning

confidence: 99%

“…43 In humans, allogenic bone is less osteoinductive than in experimental models. It is believed that this is primarily related to the immunologic factors of the different species.…”

Section: Discussionmentioning

confidence: 99%

Prefabricated Bone Flap

Rodrigues¹,

Reis²,

Denadai³

et al. 2013

Journal of Craniofacial Surgery

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“…Looking at the orthopaedic experience with homograft for articular reconstruction (i.e., knee or shoulder reconstruction), we have planned a homograft reconstruction from a nonalive donor patient. [5][6][7][8] For this purpose the Treviso tissue bank has been alerted for a compatible donor patient. The matching did not consider HLA system of compatibility as the treatment of the grafted specimen inactivates the HLA system of the tissues, but the side of the reconstruction together with the age of the donor patient was compared with the recipient patient.…”

Section: Case Reportmentioning

confidence: 99%

Temporomandibular joint, skull base and mandibular ramus functional reconstruction with homologous bank tissue and free flap: A case report with 30 months follow‐up

et al. 2009

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Big craniofacial resections for highly invasive malignant neoplasm, including skull base and maxillary bones, always represent a difficult chance for the reconstructive surgeon. In these cases it is not easy to restore anatomy and function simultaneously even adopting complex microsurgical techniques. In maxillofacial and oral surgery, simple bone homotransplantation for small bone segments reconstruction has been developing as popular technique and tissue banks offer not only bone segments but also many different tissues including complex body parts. In this paper we present, a case report of a homotransplantation of a complete temporomandibular joint (TMJ) together with a portion of the medial skull base and mandibular ramus folded with an ante-brachial fascio-periosteal free flap as secondary reconstruction after nearly 5 years from the removal of a sarcoma of the TMJ involving the skull base and a follow up of more than 30 months.

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Preserved Bone Allografts in Reconstructive Orthopaedics

Cited by 8 publications

References 6 publications

Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects

Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects

Prefabricated Bone Flap

Temporomandibular joint, skull base and mandibular ramus functional reconstruction with homologous bank tissue and free flap: A case report with 30 months follow‐up

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