Preservation of the Endothelium in Cardiovascular Surgery – Some Practical Suggestions – A review

Steen, Stig

doi:10.1080/140174301317116253

Cited by 10 publications

(8 citation statements)

References 51 publications

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“…the sarcoplasmic reticulum and the transverse tubules, need to be fully preserved. The most vulnerable structure in the heart is the vascular endothelium, which produces a variety of substances that regulate vascular permeability, vessel tone, coagulation, fibrinolysis and inflammatory responses [7]. The transverse tubules and sarcoplasmic reticulum with their ion channels, ion exchangers, and ion pumps may be characterized as membrane pathways that completely penetrate the heart, and are necessary for excitation-contraction coupling; unless their function is preserved, arrhythmia and heart failure will occur.…”

Section: Discussionmentioning

confidence: 99%

Intact coronary and myocardial functions after 24 hours of non-ischemic heart preservation

Qin

Wohlfart

Zuo

et al. 2019

Scandinavian Cardiovascular Journal

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Objectives. The aim of this study was to investigate endothelium dependent relaxation (EDR) in coronary artery and the myocardial contractility after 24 h of non-ischemic heart preservation (NIHP). Design. Explanted cardioplegic hearts from six pigs were preserved by NIHP for 24 h. The perfusion medium consisted of an albumin containing hyperoncotic cardioplegic nutrition-hormone solution with erythrocytes to a hematocrit of 10%. Coronary artery ring segments were then studied in organ baths. Thromboxane A 2 was used for vasocontraction and Substance P to elicit endothelium dependent relaxation. A heart trabecula from the right ventricle was mounted in an organ bath and a special stimulation protocol was used to characterize myocardial contractility. Fresh cardioplegic hearts from 11 pigs were used as controls. The water content of the hearts was calculated. Results. There was no significant difference between NIHP and fresh controls regarding EDR (91.2 ± 1.2% vs 93.1 ± 1.8%). The contraction force, potentiation and calcium recirculation fraction did not differ between the groups. The water content of the myocardium was 79.3 ± 0.2% for NIHP and 79.5 ± 0.2% for controls. Conclusions. NIHP for 24 h keeps coronary artery EDR and myocardial contractility intact and causes no edema.

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Section: Discussionmentioning

confidence: 99%

Intact coronary and myocardial functions after 24 hours of non-ischemic heart preservation

Qin

Wohlfart

Zuo

et al. 2019

Scandinavian Cardiovascular Journal

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“…Compromised endothelial preservation can lead to vasospasms, occlusive intimal hyperplasia and accelerated atherosclerosis. 25 Other reports have indicated the occurrence of apoptosis and SMC loss in the tunica media 23,26 which, together with intimal proliferative lesions, can lead to chronic rejection of the arterial allograft. 26 Figure 6.…”

Section: Discussionmentioning

confidence: 98%

Inhibiting Connexin Channels Protects Against Cryopreservation-induced Cell Death in Human Blood Vessels

Bol

Geyt

Baert

et al. 2013

European Journal of Vascular and Endovascular Surgery

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“…Disturbance of the functional integrity of the vascular endothelium, known as "endothelium dysfunction", plays a significant role in myocardial ischemia-reperfusion injury (3)(4)(5)(6)(10)(11)(12). The vascular endothelium is a single layer of cells that lines the entire circulatory system.…”

Section: Discussionmentioning

confidence: 99%

“…When well preserved, the endothelium is antithrombogenic and yet promotes platelet aggregation and coagulation if injured. Vasospasm, intimal hyperplasia and accelerated atherosclerosis can occur as a result of inadequate endothelial preservation (5,6).…”

Section: Introductionmentioning

confidence: 99%

Intact endothelial and contractile function of coronary artery after 8 hours of heart preservation

Qin

Sjöberg

Liao

et al. 2016

Scandinavian Cardiovascular Journal

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Objectives. The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation.Design. Porcine hearts were perfused for 8 hours at 8°C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a cardioplegic, hyperoncotic nutrition solution with oxygenated red cells, and the perfusion pressure was 20 mmHg. In organ baths, coronary artery segments from the preserved hearts were studied and compared to fresh controls.Results. Endothelium-dependent relaxation and contractility were fully preserved after both intermittent and continuous perfusion, as compared to fresh controls. No myocardial edema was seen; water content of the myocardium was 79.5±0.2%, 79.0±0.4% and 79.0±0.3% (ns) for fresh controls, intermittently perfused, and continuously perfused hearts, respectively.

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Preservation of the Endothelium in Cardiovascular Surgery – Some Practical Suggestions – A review

Cited by 10 publications

References 51 publications

Intact coronary and myocardial functions after 24 hours of non-ischemic heart preservation

Intact coronary and myocardial functions after 24 hours of non-ischemic heart preservation

Inhibiting Connexin Channels Protects Against Cryopreservation-induced Cell Death in Human Blood Vessels

Intact endothelial and contractile function of coronary artery after 8 hours of heart preservation

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