Preservation of rutin nanosuspensions without the use of preservatives

Stahr, Pascal L; Keck, Cornelia M.

doi:10.3762/bjnano.10.185

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…Partially water-miscible solvents such as ethyl acetate, ethyl formate, butyl lactate, triacetin, propylene carbonate, and benzyl alcohol are also preferred over conventional hazardous solvents like dichloromethane in the formulation process. 31 , 48 …”

Section: Factors Affecting the Stability And Efficacy Of Nanosuspensionmentioning

confidence: 99%

“…Finally, cryoprotectants are employed to safeguard the nanosuspension during freezing and thawing procedures. 48 , 49 …”

Section: Factors Affecting the Stability And Efficacy Of Nanosuspensionmentioning

confidence: 99%

“…To assess the particle size distribution, several methods are available, including photon correlation spectroscopy (PCS), laser diffraction (LD), and the Coulter Counter Multisizer. 40 , 48 , 49 …”

Section: Parameters Evaluated Reflecting Characteristics Of Nanosuspe...mentioning

confidence: 99%

“…However, the few published findings have unequivocally demonstrated the potential benefits of this approach for enhancing the cutaneous bioavailability of active ingredients with low to medium solubility. 48 , 51 In fact, nanocrystals not only exhibit improved saturation solubility and dissolution rates but also display increased adhesiveness to the skin, thereby enhancing cutaneous distribution.…”

Section: Topical Applications Of Nanosuspensionsmentioning

confidence: 99%

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Nanosuspension-Based Drug Delivery Systems for Topical Applications

Aldeeb,

Wilar,

Suhandi

et al. 2024

IJN

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Nanosuspensions have garnered recent attention as a promising strategy for mitigating the bioavailability challenges of hydrophobic drugs, particularly those characterized by poor solubility in both aqueous and organic environments. Addressing solubility issues associated with poorly water-soluble drugs has largely resolved the need to enhance drug absorption and bioavailability. As mucosal formulations and topical administration progress in the future, nanosuspension drug delivery, straightforward formulation techniques, and versatile applications will continue to be subjects of interest. Nanosuspensions have undergone extensive scrutiny in preparation for topical applications, encompassing ocular, pulmonary, and dermal usage. Among the numerous methods aimed at improving cutaneous application, nanocrystals represent a relatively recent yet profoundly intriguing approach. Despite the increasing availability of various nanosuspension products, primarily designed for oral administration, only a limited number of studies have explored skin permeability and drug accumulation in the context of nanosuspensions. Nevertheless, the scant published research unequivocally underscores the potential of this approach for enhancing cutaneous bioavailability, particularly for active ingredients with low to medium solubility. Nanocrystals exhibit increased skin adhesiveness in addition to heightened saturation solubility and dissolution rate, thereby augmenting cutaneous distribution. The article provides a comprehensive overview of nanosuspensions for topical application. The methodology employed is robust, with a well-defined experimental design; however, the limited sample size raises concerns about the generalizability of the findings. While the results demonstrate promising outcomes in terms of enhanced drug delivery, the discussion falls short of addressing certain limitations. Additionally, the references largely focus on recent studies, but a more diverse inclusion of historical perspectives could offer a more holistic view of the subject.

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Section: Factors Affecting the Stability And Efficacy Of Nanosuspensionmentioning

confidence: 99%

“…Finally, cryoprotectants are employed to safeguard the nanosuspension during freezing and thawing procedures. 48 , 49 …”

Section: Factors Affecting the Stability And Efficacy Of Nanosuspensionmentioning

confidence: 99%

Section: Parameters Evaluated Reflecting Characteristics Of Nanosuspe...mentioning

confidence: 99%

Section: Topical Applications Of Nanosuspensionsmentioning

confidence: 99%

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Nanosuspension-Based Drug Delivery Systems for Topical Applications

Aldeeb,

Wilar,

Suhandi

et al. 2024

IJN

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“…Among the safe choices of organic solvents are triacetin, ethyl formate, butyl lactate, benzyl alcohol, and ethyl acetate. 91,92 Mixing Speed…”

Section: Organic Solventsmentioning

confidence: 99%

Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery

Wathoni,

Herdiana,

Suhandi

et al. 2024

IJN

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Nanoparticle systems integrating alginate and chitosan emerge as a promising avenue to tackle challenges in leveraging the potency of pharmacological active agents. Owing to their intrinsic properties as polysaccharides, alginate and chitosan, exhibit remarkable biocompatibility, rendering them conducive to bodily integration. By downsizing drug particles to the nano-scale, the system enhances drug solubility in aqueous environments by augmenting surface area. Additionally, the system orchestrates extended drug release kinetics, aligning well with the exigencies of chronic drug release requisite for antibacterial therapeutics. A thorough scrutiny of existing literature underscores a wealth of evidence supporting the utilization of the alginate-chitosan nanoparticle system for antibacterial agent delivery. Literature reviews present abundant evidence of the utilization of nanoparticle systems based on a combination of alginate and chitosan for antibacterial agent delivery. Various experiments demonstrate enhanced antibacterial efficacy, including an increase in the inhibitory zone diameter, improvement in the minimum inhibitory concentration, and an enhancement in the bacterial reduction rate. This enhancement in efficacy occurs due to mechanisms involving increased solubility resulting from particle size reduction, prolonged release effects, and enhanced selectivity towards bacterial cell walls, stemming from ionic interactions between positively charged particles and teichoic acid on bacterial cell walls. However, clinical studies remain limited, and there are currently no marketed antibacterial drugs utilizing this system. Hence, expediting clinical efficacy validation is crucial to maximize its benefits promptly.

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Investigation of Formulation and Process Parameters of Wet Media Milling to Develop Etodolac Nanosuspensions

Karakucuk

Çelebi

2020

Pharm Res

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Preservation of rutin nanosuspensions without the use of preservatives

Cited by 6 publications

References 27 publications

Nanosuspension-Based Drug Delivery Systems for Topical Applications

Nanosuspension-Based Drug Delivery Systems for Topical Applications

Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery

Investigation of Formulation and Process Parameters of Wet Media Milling to Develop Etodolac Nanosuspensions

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