Preservation of Normal Human Plasma in the Liquid State. Iii. Studies on Chemical and Physico-Chemical Changes During the Second Year of Storage 12

Abstract

The present regulations of the National Institute of Health with regard to the preservation of plasma in the liquid state call for an expiration date of one year. In the first paper of this series (1)

Preservation of Normal Human Plasma in the Liquid State. I. A Statistical Study of 1751 Administrations 1

“…The findings presented in this study, coupled with those presented in the following papers (1,2,6), indicate that when plasma is prepared by a "closed" system with scrupulously aseptic technique, it may be preserved in the liquid state for many months and be administered with safety and benefit. The mean age of the plasma before administration was 5 months; 545 administrations were of plasma over 6 months old.…”

Preservation of Normal Human Plasma in the Liquid State. Ii. Comparative in Vitro Studies on the Physiologic Activity of Labile Constituents of Liquid and Frozen Plasma 12

“…The data in the paper immediately following (19) indicate that even after storage in the liquid form for as long as two years, there is minimal protein degradation. It is of interest therefore that the present studies indicate that the physiological activity of prothrombin, and possibly other components of the blood coagulation reaction together with complement, have completely vanished within 6 months.…”