Preservation of Musical Memory Throughout the Progression of Alzheimer’s Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence

Groussard, Mathilde; Chan, Tyler G; Coppalle, Renaud; Platel, Hervé

doi:10.3233/jad-180474

Cited by 23 publications

(17 citation statements)

References 101 publications

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“…From an evolutionary perspective, it may clarify the extent to which evolving musical capabilities in modern humans took advantage of the ancient oxytocinergic network to facilitate prosocial interactions, promote trust and reciprocal affiliative behaviors, and help reduce levels of anxiety and individual insecurity throughout life. It will also contribute to a better understanding of the mechanisms that underlie the mental and general health benefits of music, its remarkable emotional and mnemonic power, it’s capacity to alter brain architecture, and its ability to revitalize episodic memories (Zhang et al, 2017 ; Särkämö and Sihvonen, 2018 ), especially vulnerable in early stages of Alzheimer’s disease (Groussard et al, 2019 ; Slattery et al, 2019 ).…”

Section: Conclusion and Therapeutic Implicationsmentioning

confidence: 99%

“…Music, via its impact on various regions within the limbic system, is also rewarding, motivating, and facilitates aspects of learning and memory (Zatorre and Salimpoor, 2013 ; Koelsch, 2018 ). Lastly, and no less important, it is increasingly appreciated that musical activities are useful therapeutic tools, aiding in the treatment of some developmental disorders (Quintin, 2019 ), and capable of ameliorating behavioral and psychological symptoms in several neurodegenerative conditions (e.g., Abraha et al, 2017 ; Zhang et al, 2017 ; Särkämö and Sihvonen, 2018 ; Groussard et al, 2019 ; Pereira et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Links Between the Neurobiology of Oxytocin and Human Musicality

Harvey

2020

Front. Hum. Neurosci.

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The human species possesses two complementary, yet distinct, universal communication systems—language and music. Functional imaging studies have revealed that some core elements of these two systems are processed in closely related brain regions, but there are also clear differences in brain circuitry that likely underlie differences in functionality. Music affects many aspects of human behavior, especially in encouraging prosocial interactions and promoting trust and cooperation within groups of culturally compatible but not necessarily genetically related individuals. Music, presumably via its impact on the limbic system, is also rewarding and motivating, and music can facilitate aspects of learning and memory. In this review these special characteristics of music are considered in light of recent research on the neuroscience of the peptide oxytocin, a hormone that has both peripheral and central actions, that plays a role in many complex human behaviors, and whose expression has recently been reported to be affected by music-related activities. I will first briefly discuss what is currently known about the peptide’s physiological actions on neurons and its interactions with other neuromodulator systems, then summarize recent advances in our knowledge of the distribution of oxytocin and its receptor (OXTR) in the human brain. Next, the complex links between oxytocin and various social behaviors in humans are considered. First, how endogenous oxytocin levels relate to individual personality traits, and then how exogenous, intranasal application of oxytocin affects behaviors such as trust, empathy, reciprocity, group conformity, anxiety, and overall social decision making under different environmental conditions. It is argued that many of these characteristics of oxytocin biology closely mirror the diverse effects that music has on human cognition and emotion, providing a link to the important role music has played throughout human evolutionary history and helping to explain why music remains a special prosocial human asset. Finally, it is suggested that there is a potential synergy in combining oxytocin- and music-based strategies to improve general health and aid in the treatment of various neurological dysfunctions.

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Section: Conclusion and Therapeutic Implicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Links Between the Neurobiology of Oxytocin and Human Musicality

Harvey

2020

Front. Hum. Neurosci.

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“…Therefore, the answers of the participants were collected and coded using the Sense of Familiarity (SoF) Scale (Table 2), created by our team [22,24,29] for the purpose of studying memory with people suffering memory losses (for examples of its use, please refer to supplementary video data). The assessment of the scale consists in questioning the person regarding the familiarity he/she has towards each item.…”

Section: Materials Assessment Of the Sense Of Familiaritymentioning

confidence: 99%

“…They maintain a good musical appreciation at perceptual and emotional levels [18], while their other cognitive abilities (especially verbal) are largely deteriorated. Yet, aside from the psychosocial, well-being, and behavioral benefits [19,20], these studies also have shown that many aspects of retrograde memory for music in PWAD are well-preserved (semantic memory for old songs, and musical or vocal performance of previously learned pieces for musicians) [21,22]. In addition, a few authors used repeated exposure (6 presentations or more) to songs with PWAD and demonstrated evidence of possible explicit learning, such as the case study of a PWAD at a severe stage without musical training learning a new song [15], and a group of patients at a mild to moderate stage learning made-up songs mixing autobiographical memories and familiar melodies [23].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, a few authors used repeated exposure (6 presentations or more) to songs with PWAD and demonstrated evidence of possible explicit learning, such as the case study of a PWAD at a severe stage without musical training learning a new song [15], and a group of patients at a mild to moderate stage learning made-up songs mixing autobiographical memories and familiar melodies [23]. Furthermore, a few group studies have given arguments for the possibility of encoding of recentlypresented musical items [22,24].…”

Section: Introductionmentioning

confidence: 99%

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New Long-Term Encoding in Severely Amnesic Alzheimer’s Disease Patients Revealed Through Repeated Exposure to Artistic Items

Coppalle

Mauger

Quernet³

et al. 2020

JAD

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Background: Encoding of new information is considered to be impossible in people with Alzheimer's disease (PWAD) at a moderate to severe stage. However, a few case studies reported new learning under special circumstances, especially with music. Objective: This article aims at clarifying PWAD's learning capacities toward unknown material under more ecological settings, which is repeated exposure without encoding instruction. Methods: Twenty-three PWAD (Age: m = 84.6(5.2), 5 ≤ MMSE ≤ 19) underwent presentations of unknown artistic pieces (targets) through 8 daily individual sessions. These sessions were followed by a test session, during which their knowledge of the targets was assessed through a verbal and behavioral scale (the sense of familiarity scale) against a series of unknown items (distractors). Results: Through this design, we were able to objectify encoding of three types of targets (verses, paintings, and music) against distractors the day after exposure sessions, and 2 months after the last presentation (study 1). Music and paintings were eventually well-encoded by most participants, whereas poems encoding was poorer. When compared to distractors, target items were significantly better recognized. We then compared the recognition of target paintings against two types of painting distractors, either perceptually or semantically related (study 2). The targets were better recognized than all three painting distractors, even when they were very close to the targets. Conclusion: Despite massive anterograde amnesia, our results clearly showed that recognition-based learning without conscious memory of the encoding context is preserved in PWAD at a severe stage, revealed through an increasing sense of familiarity following repeated exposure. These findings could open new perspective both for researchers and clinicians and improve the way we understand and care for PWAD living in healthcare facilities.

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Disorders of music processing in dementia

Benhamou

Warren

2020

Music and the Aging Brain

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Preservation of Musical Memory Throughout the Progression of Alzheimer’s Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence

Cited by 23 publications

References 101 publications

Links Between the Neurobiology of Oxytocin and Human Musicality

Links Between the Neurobiology of Oxytocin and Human Musicality

New Long-Term Encoding in Severely Amnesic Alzheimer’s Disease Patients Revealed Through Repeated Exposure to Artistic Items

Disorders of music processing in dementia

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