Preservation of Gastric Acid Secretion May Be Important for the Development of Gastroesophageal Junction Adenocarcinoma in Japanese People, Irrespective of the H. pylori Infection Status

Inomata, Yoshifumi; Koike, Tomoyuki; Ohara, Shuichi; Abe, Yasuhiko; Sekine, Hitoshi; Iijima, Katsunori; Ariizumi, Ken; Yamagishi, Hatsushi; Kitagawa, Yasushi; Imatani, Akira; Shimosegawa, Tooru

doi:10.1111/j.1572-0241.2006.00497.x

Cited by 45 publications

(41 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reason for the unreliability of serum markers in detecting diffuse-type cancer is that most of these cancers occur without gastric atrophy, as reported by Inomata et al [32]. This suggests that normal acid secretion may be important for the development of diffuse-type adenocarcinoma, particularly at the gastroesophageal junction.…”

Section: Discussionmentioning

confidence: 94%

Serum Nitrate/Nitrite Concentration Correlates with Gastric Juice Nitrate/Nitrite: A Possible Marker for Mutagenesis of the Proximal Stomach

Kishikawa¹,

Nishida²,

Ichikawa³

et al. 2011

Digestion

View full text Add to dashboard Cite

Background/Aims: In the normal acid-secreting stomach, luminally generated nitric oxide, which contributes to carcinogenesis in the proximal stomach, is associated with the concentration of nitrate plus nitrite (nitrate/nitrite) in gastric juice. We investigated whether the serum nitrate/nitrite concentration is associated with that of gastric juice and whether it can be used as a serum marker. Methods: Serum and gastric juice nitrate/nitrite concentration, Helicobacter pylori antibody, and gastric pH were measured in 176 patients undergoing upper endoscopy. Results: Multiple regression analysis revealed that serum nitrate/nitrite concentration was the best independent predictor of gastric juice nitrate/nitrite concentration. On single regression analysis, serum and gastric juice nitrate/nitrite concentration were significantly correlated, according to the following equation: gastric juice nitrate/nitrite concentration (µmol/l) = 3.93 – 0.54 × serum nitrate/nitrite concentration (µmol/l; correlation coefficient = 0.429, p < 0.001). In analyses confined to subjects with gastric pH less than 2.0, and in those with serum markers suggesting normal acid secretion (pepsinogen-I >30 ng/ml and negative H. pylori antibody), the serum nitrate/nitrite concentration was an independent predictor of the gastric juice nitrate/nitrite concentration (p < 0.001). Conclusion: Measuring the serum nitrate/nitrite concentration has potential in estimating the gastric juice nitrate/nitrite concentration. The serum nitrate/nitrite concentration could be useful as a marker for mutagenesis in the proximal stomach.

show abstract

Section: Discussionmentioning

confidence: 94%

Serum Nitrate/Nitrite Concentration Correlates with Gastric Juice Nitrate/Nitrite: A Possible Marker for Mutagenesis of the Proximal Stomach

Kishikawa¹,

Nishida²,

Ichikawa³

et al. 2011

Digestion

View full text Add to dashboard Cite

show abstract

“…With this method, we measured gastric acid secretion level in a series of patients with various upper GI diseases such as peptic ulcer, reflux esophagitis, Barrett's esophagus, and superficial gastric or esophageal cancer (Iijima et al 1998(Iijima et al , 2000(Iijima et al , 2005(Iijima et al , 2010Koike et al 2001;Abe et al 2004;Inomata et al 2006;Iwai et al 2013). In this study, we retrospectively analyzed the accumulated database based on our previous studies and investigated the correlation between gastric acid secretion levels and serum PG values.…”

Section: Introductionmentioning

confidence: 99%

Cutoff Serum Pepsinogen Values for Predicting Gastric Acid Secretion Status

Iijima

Koike

Abe

et al. 2014

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

Measurement of the gastric acid secretion is useful for estimating the risk for various diseases in the upper gastro-intestinal tract; however, the procedure causes significant distress to the subjects. Pepsinogens I and II are secreted from the gastric fundic glands, and thus, the serum pepsinogen levels reflect the gastric functional statuses. The aim of this study is to establish appropriate serum pepsinogen cutoff points for predicting the gastric acid secretion status. In a total of 627 Japanese subjects, gastric acid secretion was measured with an endoscopic gastrin test, and the serum pepsinogen values and serum Helicobacter (H.) pylori-IgG antibody were also measured. After checking the correlation between gastric acid secretion and serum pepsinogen, the receiver operating characteristics analyses were employed for determining the most suitable cutoff points of serum pepsinogen for the gastric acid secretion status (i.e., hypochlorhydria, profound hypochlorhydria, and hyperchlorhydria). The pepsinogen I/II ratio and pepsinogen I showed the best correlation with gastric acid secretion in H. pylori-positive and H. pylori-negative subjects, respectively. The serum pepsinogen I/II ratio (or pepsinogen I in cases of H. pylori-negative subjects) was useful to determine the gastric acid secretion status with acceptable to outstanding diagnostic accuracy (the range of the area under the curve: 0.79-0.93). The diagnostic accuracy was further improved after stratifying the subjects by H. pylori-infection status. Estimating gastric acid secretion levels by simple measurement of serum pepsinogens will have significant clinical implications in estimating the risks for various diseases of the upper gastrointestinal tract.

show abstract

“…As found in other studies, a study from Japan showed that H. pylori infection may play a protective role in the development of BE (especially LSBE), although the number of patients evaluated was limited [90]. The same group proposed that the preservation of gastric acid secretion might be important for the development of adenocarcinoma at the EGJ (including EAC) in Japanese people, irrespective of the H. pylori infection status [91]. Namely, there may be two distinct types of cancer at the EGJ-EAC (BE cancer) associated with high gastric acid secretion and reflux of gastric acid into the esophagus and EGJ adenocarcinoma (non-BE cancer) resembling distal gastric cancer associated with gastric atrophy and low gastric acid secretion [92,93].…”

Section: H Pylori Infection and Carcinogenesismentioning

confidence: 78%

Carcinogenesis of Barrett’s esophagus: a review of the clinical literature

Watari

Oshima

Fukui

et al. 2013

Clin J Gastroenterol

View full text Add to dashboard Cite

Barrett's esophagus (BE) is a premalignant condition of esophageal adenocarcinoma (EAC). Although the incidence of BE has risen rapidly in the West, it is rare in Asia despite a recent increase in the prevalence of gastroesophageal reflux disease. Controversies over the definition of BE are presented because most cases show shortsegment BE, especially ultra-short BE, in Asia. Here we review possible risk factors for the development of EAC, particularly possible roles of ethnicity, specialized intestinal metaplasia (SIM), BE length, and environmental factors, such as Helicobacter pylori infection and obesity. Additionally, we summarize recent studies on the effect of chemoprevention including proton pump inhibitors, nonsteroidal anti-inflammatory drugs or aspirin in order to reduce the risk of neoplastic progression in BE patients. Although substantial knowledge of risk factors of dysplasia/EAC in BE is shown, the risk for neoplastic development may be influenced by geographic variation, study population, the presence or absence of SIM or dysplasia at baseline, and the small number of BE patients investigated. Recently, the efficiency of surveillance for BE patients has been discussed from the standpoint of cost-effectiveness. It may be too difficult to draw conclusions because no randomized clinical trials of BE surveillance have been performed.

show abstract

Preservation of Gastric Acid Secretion May Be Important for the Development of Gastroesophageal Junction Adenocarcinoma in Japanese People, Irrespective of the H. pylori Infection Status

Abstract: Preservation of gastric acid secretion may be important for the development of GE junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status.

Cited by 45 publications

References 43 publications

Serum Nitrate/Nitrite Concentration Correlates with Gastric Juice Nitrate/Nitrite: A Possible Marker for Mutagenesis of the Proximal Stomach

Serum Nitrate/Nitrite Concentration Correlates with Gastric Juice Nitrate/Nitrite: A Possible Marker for Mutagenesis of the Proximal Stomach

Cutoff Serum Pepsinogen Values for Predicting Gastric Acid Secretion Status

Carcinogenesis of Barrett’s esophagus: a review of the clinical literature

Contact Info

Product

Resources

About