Preservation of Cardiac Extracellular Matrix by Passive Myocardial Restraint

Shah, Prediman K.

doi:10.1161/circulationaha.105.554725

Cited by 5 publications

(3 citation statements)

References 27 publications

(20 reference statements)

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“…This process is called ventricular remodelling and results in significant changes in the geometry and shape of the cardiac ventricles leading to further increases in diastolic volume. Thus, a vicious circle ensues where increased diastolic volume leads to more ventricular remodelling which leads to further increments in diastolic volume etc …”

Section: Introductionmentioning

confidence: 99%

“…Thus, a vicious circle ensues where increased diastolic volume leads to more ventricular remodelling which leads to further increments in diastolic volume etc. [3,4] Tissue engineering (TE) of materials loaded with stem cells is the next evolution of MI treatment. [4] However, TE of heart ventricle wall tissues require materials with very specific properties.…”

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confidence: 99%

“…Action potentials (APs) recorded from atrial HL-1 cells cultured on diffrent CNT:Collagen hydogels (Nos [1][2][3][4][5][6][7][8]…”

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confidence: 99%

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Rational Design of a Conductive Collagen Heart Patch

Sherrell

Cieślar-Pobuda

Ejneby

et al. 2017

Macromolecular Bioscience

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Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly implanted on a myocardial infarct is an attractive solution. Hydrogels made of collagen are highly biocompatible materials that can be molded into a range of shapes suitable for cardiac patch applications. The addition of mechanically reinforcing materials, carbon nanotubes, at subtoxic levels allows for the collagen hydrogels to be strengthened, up to a toughness of 30 J m and a two to threefold improvement in Youngs' modulus, thus improving their viability as cardiac patch materials. The addition of carbon nanotubes is shown to be both nontoxic to stem cells, and when using single-walled carbon nanotubes, supportive of live, beating cardiac cells, providing a pathway for the further development of a cardiac patch.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%