Preservation of Bile Ductules Mitigates Bile Duct Loss

Heuvel, Marius C. van den; Jong, Koert P. de; Boot, Marcel; Slooff, Maarten J. H.; Poppema, Sibrand; Gouw, Annette S.H.

doi:10.1111/j.1600-6143.2006.01511.x

Cited by 15 publications

(3 citation statements)

References 23 publications

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“…58 The preservation and proliferation of bile ductules has been documented to mitigate bile duct loss in chronic allograft rejection. 59 These observations are all in line with the hypothesis of a multitiered, flexible system of hepatic regeneration, which benefits from the existence of several sources, rather than a singular one, of hepatic progenitor cells. 60…”

Section: Drug-induced Loss Of Intrahepatic Bile Ductssupporting

confidence: 69%

Loss of Intrahepatic Bile Ducts

Gouw¹

2018

Practical Hepatic Pathology: A Diagnostic Approach

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Section: Drug-induced Loss Of Intrahepatic Bile Ductssupporting

confidence: 69%

Loss of Intrahepatic Bile Ducts

Gouw¹

2018

Practical Hepatic Pathology: A Diagnostic Approach

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“…The intrahepatic biliary system is supported by the peribiliary vascular plexus (PBP) which is fed by branches of the hepatic artery. There is developing research emphasizing the importance of the PBP in maintaining the health of the biliary tree, especially in the setting of acute injury and regeneration [19–21]. One hypothesis for the increased rate of biliary complications observed in this case series is the role of sorafenib and VEGF receptor inhibition (VEGFR‐2, VEGFR‐3).…”

Section: Discussionmentioning

confidence: 99%

Sorafenib therapy for hepatocellular carcinoma prior to liver transplant is associated with increased complications after transplant

Truesdale¹,

Caldwell²,

Shah³

et al. 2011

Transplant International

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Summary This study compared post‐transplant outcomes of patients with hepatocellular carcinoma (HCC) who took sorafenib prior to orthotopic liver transplantation (OLT) with those patients who were not treated with sorafenib. Thirty‐three patients with HCC who were listed for liver transplantation were studied: 10 patients were treated with sorafenib prior to transplantation in an attempt to prevent progression of HCC while awaiting transplant. The remaining 23 patients were considered controls. The mean duration of sorafenib use was 19.2 (SD 25.2) weeks. Overall death rates were similar between the sorafenib group and control group (20% vs. 8.7%, respectively, P = 0.56). However, the patients in the sorafenib group had a higher incidence of acute cellular rejection following transplantation (67% vs. 22%, OR = 7.2, 95% CI 1.3–39.6, P = 0.04). The sorafenib group also had a higher rate of early biliary complications (67% vs. 17%, OR = 9.5, 1.6–55.0, P = 0.01). The use of sorafenib was found to be an independent predictor of post‐transplant biliary complications (OR 12.6, 1.4–116.2, P = 0.03). Sorafenib administration prior to OLT appears to be associated with an increase in biliary complications and possibly in acute rejection following liver transplantation. Caution should be taken in this setting until larger studies are completed.

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“…There have been speculations about bile ductule escorting hepatic arterioles [18,19,25,26,27] but no convincing evidence has been published so far. Gouw et al [19] and van der Heuvel et al [28] emphasize the importance of the microvascular compartment for the effi cient regeneration of ductules.…”

Section: Distribution Of Hepatic Ductules In the Liver Parenchymamentioning

confidence: 98%

Architectural and Immunohistochemical Characterization of Biliary Ductules in Normal Human Liver

Dezső

Paku

Papp

et al. 2009

Stem Cells and Development

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The canals of Hering or biliary ductules have been described to connect the bile canaliculi with the interlobular bile ducts, and thus forming the distal part of the biliary tree. Studies in the last two decades suggested that the cells constructing these ductules could behave as hepatic progenitor cells. The canals of Hering are confined to the periportal space in the rat, while they have been reported to spread beyond the limiting plate in human liver. The distribution of the distal biliary ductules in normal human hepatic tissue has been investigated in our recent experiments. We could demonstrate the presence of interlobular connective tissue septa in a rudimentary form in healthy livers. The canals of Hering run in these septa in line with the terminal branches of the portal vein and hepatic arteries. This arrangement develops in the postnatal period but regresses after early childhood. The canals of Hering can be identified by the unique epithelial membrane antigen (EMA)-/CD56+/CD133+ immunophenotype. The canals of Hering leave the periportal space and spread into the liver parenchyma along rudimentary interlobular septa outlining the hepatic lobules. Our observations refine the original architectural description of the intraparenchymal portion of the canals of Hering in the human liver. The distinct immunophenotype supports their unique biological function.

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Preservation of Bile Ductules Mitigates Bile Duct Loss

Cited by 15 publications

References 23 publications

Loss of Intrahepatic Bile Ducts

Loss of Intrahepatic Bile Ducts

Sorafenib therapy for hepatocellular carcinoma prior to liver transplant is associated with increased complications after transplant

Architectural and Immunohistochemical Characterization of Biliary Ductules in Normal Human Liver

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