Preservation of anaplastic features in Wilms' Tumors after preoperative chemotherapy

Abstract

In 4 of 35 childhood Wilms' tumors on record in the Hospital Infantil Virgen de Rocio de Sevilla, it was possible to identify diffuse anaplasia despite the fact these children had received cytoreductive chemotherapy preoperatively.

New definitions of focal and diffuse anaplasia in Wilms tumor: The International Society of Paediatric Oncology (SIOP) experience

“…A similar incidence was noted in the present study despite preoperative chemotherapy applied in the SIOP 6 and 9 trials and studies. Other series dealing with pretreated WT have noted that anaplastic features have been preserved after preoperative chemotherapy [7][8][9][10]. In a way, it even makes a diagnosis of anaplasia easier since nonanaplastic areas are destroyed by chemotherapy while anaplastic foci remained unchanged.…”

“…1 and 2) proposed by Beckwith and Palmer [1]. Hematoxylin and eosin slides were available in all cases but the number of slides varied from 4 to 34 (average and median, 8).…”

Wilms tumour with unfavourable histology: Implications for clinicians in the third world

“…It is equally important to identify, among patients with treatable tumours such as Wilms tumour, those who have negative prognostic features that will reduce the yield of expensive therapy. In an environment in which neoadjuvant therapy is frequently a matter of necessity rather than choice [9], it is important to recognise that anaplastic features are not destroyed by such treatment [9,10], and this negative marker is not masked by chemotherapy.…”

Durchführung eines neuen Therapiekonzepts für Nephroblastome im Bereich der Gesellschaft für Pädiatrische Onkologie und Hämatologie SIOP 9/GPOH

“…14 Kliniken aus den neuen Bundeslä ndern schlossen sich ab1. 14 Kliniken aus den neuen Bundeslä ndern schlossen sich ab1.…”