Presepsin as a predictor of early onset neonatal sepsis in the umbilical cord blood of premature infants with premature rupture of membranes

Seliem, Wael; Sultan, Amira M.

doi:10.1111/ped.13541

Cited by 21 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…59 A cord-blood presepsin level >1,370 pg/mL was found to be an independent predictor of EOS in the setting of preterm rupture of membranes, with an OR of 12.6 (95% CI 2.5-28.1, P=0.000). 70 Normal levels of presepsin in both healthy term and preterm infants have been measured. 71 The cutoff values used in various studies looking at the diagnostic capability of presepsin have varied widely: from as low as 539 pg/mL to 1,800 ng/mL.…”

Section: Presepsinmentioning

confidence: 99%

<p>Neonatal sepsis biomarkers: where are we now?</p>

Gilfillan¹,

Bhandari²

2019

RRN

View full text Add to dashboard Cite

Given that neonatal sepsis remains an important factor contributing to mortality and morbidity in neonates, identification of accurate biomarkers to aid in its timely and accurate diagnosis is critical. In this review, we discuss the current evidence behind the use of biomarkers commonly used in clinical practice, as well as presenting recent developments in this area of research. Besides summarizing information regarding "traditional" biomarkers (eg, hematological indices, CRP, and other acute-phase reactants, cytokines), we provide the latest clinical status on some relatively "newer" biomarkers (eg, PCR-and "-omic" technology-based, biophysical biomarkers) in the diagnosis of neonatal sepsis. We believe that certain biophysical (RALIS, core-peripheral temperature differences) in combination with selective biochemical (procalcitonin, nCD64, presepsin) markers offer the best likelihood of being adopted for clinical use in the detection of neonatal sepsis in the near future. In addition, serial measurements of selective biochemical markers (procalcitonin, nCD64) offer promise in the decision to initiate and/or control the duration of antibiotic therapy. It is important to conduct adequately powered prospective multicenter studies to continue to establish the accuracy and safety of utilizing such biomarkers of neonatal sepsis so that appropriate and adequate therapy is tailored to each infant for optimal outcomes.

show abstract

Section: Presepsinmentioning

confidence: 99%

<p>Neonatal sepsis biomarkers: where are we now?</p>

Gilfillan¹,

Bhandari²

2019

RRN

View full text Add to dashboard Cite

show abstract

“…Twenty-one full-text articles were eventually included in a qualitative synthesis of current knowledge of P-SEP levels in neonates: three studies on the reference ranges in neonatal age [4,14,15], four studies on the diagnosis of early-onset sepsis (EOS) [10,[16][17][18], four studies on the diagnosis of late-onset sepsis (LOS) [1,[19][20][21] and ten studies on the diagnosis of neonatal sepsis in general (EOS and LOS considered together) [22][23][24][25][26][27][28][29][30][31].…”

Section: Resultsmentioning

confidence: 99%

The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review

Maddaloni

Rose

Santisi

et al. 2021

IJMS

View full text Add to dashboard Cite

Sepsis causes high rates of morbidity and mortality in NICUs. The estimated incidence varies between 5 and 170 per 1000 births, depending on the social context. In very low birth-weight neonates, the level of mortality increases with the duration of hospitalization, reaching 36% among infants aged 8–14 days and 52% among infants aged 15–28 days. Early diagnosis is the only tool to improve the poor prognosis of neonatal sepsis. Blood culture, the gold standard for diagnosis, is time-consuming and poorly sensitive. C-reactive protein and procalcitonin, currently used as sepsis biomarkers, are influenced by several maternal and fetal pro-inflammatory conditions in the perinatal age. Presepsin is the N-terminal fragment of soluble CD14 subtype (sCD14-ST): it is released in the bloodstream by monocytes and macrophages, in response to bacterial invasion. Presepsin seems to be a new, promising biomarker for the early diagnosis of sepsis in neonates as it is not modified by perinatal confounding inflammatory factors. The aim of the present review is to collect current knowledge about the role of presepsin in critically ill neonates.

show abstract

“…[2,3] While about 15-25% of the pregnant women with PPROM have infection symptoms at prepartum period, about 15-20% of them have clinical infection symptoms at postpartum period. [4,5] The patients with PPROM are followed up until 34 weeks of gestation or displaying clinical symptoms. [6] Any delay in the diagnosis and treatment of chorioamnionitis during patient follow-up leads to the development of infection which then results in the maternal and neonatal inflammatory response, fetal hypoxia and increased cerebral palsy risk.…”

Section: Discussionmentioning

confidence: 99%

The importance of C-reactive protein and procalcitonin in the diagnosis of chorioamnionitis in the cases with preterm premature rupture of membranes

Taşın¹,

Coşkun²

2020

Perinatal J

View full text Add to dashboard Cite

Objective: Our aim is to compare the clinical biochemical markers of the cases who developed and did not develop clinical chorioamnionitis among those hospitalized in our clinic with the diagnosis of preterm premature rupture of membranes (PPROM). For that purpose, we investigated the significance levels of mean values, sensitivity and specificity levels of the infection markers and also their correlations with each other in the diagnosis of clinical chorioamnionitis. Methods: Eighty-one cases with singleton pregnancy who were hospitalized with the pre-diagnosis of PPROM and followed up and treated in the Clinic of Gynecology and Obstetrics of the Faculty of Medicine at Mersin University were included in the study. The values of 48 cases who developed and did not develop clinical chorioamnionitis were compared. Results: The mean WBC, CRP and procalcitonin values at labor and mean procalcitonin values at hospitalization were significantly higher in the cases diagnosed with chorioamnionitis than the cases without chorioamnionitis diagnosis. Conclusion: We found out that the procalcitonin values at hospitalization and WBC, serum CRP and procalcitonin values at labor in the cases followed up with the diagnosis of PPROM were significant in clinical chorioamnionitis cases. We concluded in our study that these infection markers (procalcitonin in particular) can be used in the early diagnosis of chorioamnionitis by not checking at hospitalization only but also in the follow-ups of the patients regularly.

show abstract

Presepsin as a predictor of early onset neonatal sepsis in the umbilical cord blood of premature infants with premature rupture of membranes

Abstract: Umbilical cord blood presepsin is a predictor for EONS in preterm infants with PROM and may help to reduce the unnecessary use of antibiotics.

Cited by 21 publications

References 32 publications

<p>Neonatal sepsis biomarkers: where are we now?</p>

<p>Neonatal sepsis biomarkers: where are we now?</p>

The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review

The importance of C-reactive protein and procalcitonin in the diagnosis of chorioamnionitis in the cases with preterm premature rupture of membranes

Contact Info

Product

Resources

About