Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores

Kaplan, Mustafa; Düzenli, Tolga; Tanoğlu, Alpaslan; Güney, Başak Çakır; Tastan, Yesim Onal; Bicer, Hatice S.

doi:10.1007/s00508-020-01618-9

Cited by 19 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At cutoff value 686 pg/ml, presepsin achieved the highest specificity which could be documented by a univariant marker in this study (95.5%), in addition to sensitivity 82.7%, PPV 95.4%, NPV 83.1%, efficacy 88.7%, and AUC 0.887, respectively. These results come in line with several studies suggesting promising results for presepsin as an early diagnostic sepsis biomarker but with different cutoff values [ 4 , 9 , 25 – 33 ]. Moreover, they claimed that presepsin could be used as a useful marker to monitor treatment response as its levels decrease over time with treatment [ 55 ], which is also confirmed by the current study results.…”

Section: Discussionsupporting

confidence: 90%

“…It is a specific, high-affinity receptor for complexes of lipopolysaccharides and is involved in the recognition of a wide variety of bacterial products such as peptidoglycans; following its stimulation by pathogens, a soluble CD14 subtype is released in the circulation by shedding from the surface of the membranes of various immune cells, such as macrophages, monocytes, and neutrophils [ 4 , 24 ], which can be measured by different immunological methods. Several studies suggest promising results for presepsin as an early diagnostic and prognostic sepsis marker [ 4 , 9 , 25 – 33 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis

Hashem

Halim

Masry

et al. 2020

International Journal of Microbiology

View full text Add to dashboard Cite

Background. Neonatal septicemia is a critical medical situation; current conventional laboratory methods still have many limitations and diagnostic obstacles. For this purpose, last decades have witnessed a challenge between the battery of sepsis biomarkers including many leukocyte surface antigens, not only for early diagnostic purposes but also for better follow-up and good management of sepsis patients. Aim. To evaluate the diagnostic, prognostic, and monitoring performance of both neutrophil CD64 (nCD64) and presepsin as sepsis biomarkers compared to each other and to the conventional laboratory sepsis parameters aiming to decide which is the best fitting for routine daily use in neonatal intensive care units (NICUs). Methods. 235 neonates were enrolled from three Egyptian neonatal ICUs, during the period from November 2015 till March 2018; they were classified into two main groups: the control group (n = 102) and the sepsis group (n = 133). Laboratory sepsis evaluation included highly sensitive CRP (hs-CRP), CBC, in addition to nCD64 (flow cytometry technique), and presepsin measurement (CLEIA technique combined with Magtration® technology); the diagnosis was confirmed thereafter by positive blood culture results (BacT/Alert system). Sixty-two of the enrolled sepsis neonates were subjected to follow-up assessment; they were reclassified according to their clinical improvement at the second time assessment into (group 1: sepsis group without improvement) (n = 20) and (group 2: improved sepsis group) (n = 42). Results. Significant increase in nCD64 and presepsin values was found in sepsis groups compared to the controls. At cutoff 41.6%, nCD64% could discriminate the presence of septicemia with sensitivity 94.7%, specificity 93.6 %, and AUC 0.925, while presepsin at cutoff 686 pg/ml achieves sensitivity 82.7%, specificity 95.5%, and AUC 0.887, respectively. Significant increase in nCD64 ( P < 0.001 ) and hs-CRP ( P = 0.018 ) values was observed in severe sepsis/septic shock patients compared to nonsevere sepsis patients. Delta change percentage (dC%) between initial and follow-up evaluations for both improved and nonimproved sepsis patients was dC Z value −5.904 for nCD64% followed by dC Z value −4.494 for presepsin. Conclusion. nCD64 and presepsin are valuable early diagnostic and monitoring sepsis biomarkers; the highest sensitivity could be achieved by a univariant sepsis marker in this study was recorded by the nCD64% biomarker, while the highest specificity was documented by presepsin. Combined measurement of both achieves the highest diagnostic performance in sepsis neonates. Either of CD64 or presepsin combined with hs-CRP associated with better performance than any of them alone. nCD64 carries an additional promising role in reflecting sepsis prognosis.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis

Hashem

Halim

Masry

et al. 2020

International Journal of Microbiology

View full text Add to dashboard Cite

show abstract

“…Presepsin levels have been reported as a useful biomarker of sepsis in the emergency department or ICU [ 12 , 13 ]. Previous studies have shown that presepsin levels increase in the early stages of sepsis, representing an innate immunity response, and that they positively correlate with the severity of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis

Lee

Han

Chun

et al. 2021

JCM

View full text Add to dashboard Cite

Introduction: Early diagnosis of sepsis is paramount to effective management. The present study aimed to compare the prognostic accuracy of presepsin levels and other biomarkers in the assessment of septic shock and mortality risk in cancer patients. Materials and methods: A total of 74 cancer patients were evaluated for presepsin, lactic acid, C-reactive protein (CRP) levels, and white blood cell count (WBC). Specificity and sensitivity values for septic shock and death were compared between four biomarkers in all patients and those with and without acute kidney injury (AKI). Results: A total of 27 and 29 patients experienced septic shock and died, respectively. The area under the curve (AUC) and sensitivity and specificity estimated for presepsin levels for septic shock were 60%, 74%, and 51%, respectively. The corresponding values for mortality were 62%, 72%, and 49%, respectively. In patients without AKI, AUC of presepsin levels for septic shock and death were 62% and 65%, respectively; in those with AKI, these values were 44% and 58%, respectively. Presepsin levels showed higher sensitivity and specificity values than WBC and higher specificity than CRP but were similar to those of lactic acid levels. Conclusions: Presepsin levels are similar to lactic acid levels in the assessment of septic shock and mortality risk in cancer patients. In patients with AKI, presepsin levels should be considered carefully.

show abstract

“…Also, hypoalbuminemia is suggested to be related to the systemic inflammatory response. It has been found that patients with sepsis with hypoalbuminemia already had increased serum CRP concentrations and that hypoalbuminemia might be secondary to elevated CRP which may be explained by increased demand for specific amino acids for acute-phase protein synthesis, which promotes the degradation of available body protein including albumin Al-Shaiba et al, & Kaplan et al [25,26].…”

Section: Fig 1 Positive Correlation Between Nlr Car and Ascitic Neutrophil Count After Sbp Treatmentmentioning

confidence: 99%

Blood Neutrophil / Lymphocyte Ratio and C –Reactive Protein / Albumin Ratio as Markers of Response for Treatment of Spontaneous Bacterial Peritonitis

Mustafa

Mabrouk

Saif

et al. 2021

IJTDH

View full text Add to dashboard Cite

Background: Spontaneous bacterial peritonitis (SBP) is an acute infection of ascites with the absence of surgically treatable cause and the gold standard method in its diagnosis is the presence of 250 polymorphonuclear neutrophils (PMN) /mm3 or more by diagnostic paracentesis. Blood neutrophil/lymphocytic ratio (NLR) is an applicable, inexpensive, and simple test for inflammation. C-reactive protein/albumin ratio (CAR) is an inflammatory marker used for the diagnosis and follow-up of many diseases and morbidities. We aimed to evaluate the clinical utility of both blood NLR and CAR as applicable, simple and non-invasive tests for SBP follow-up. Patients and Methods: This study was done on 80 cirrhotic ascitic patients attending the Tropical Medicine Department of Tanta University Hospital. They were subjected to full history taking, clinical examination, laboratory investigations, and ascitic fluid analysis. The patients were divided into two groups according to the results of diagnostic paracentesis into group I: 40 cirrhotic ascitic patients without spontaneous bacterial peritonitis and group II: 40 cirrhotic ascitic patients with spontaneous bacterial peritonitis, and then SBP group were tested after treatment by third-generation cephalosporin for five days for ascitic sample, NLR and CAR. Results: Both blood NLR and CAR were significantly higher in SBP patients. Also, a significant decrease in both ratios was observed post-treatment with significant positive correlations between both NLR and CAR with ascitic neutrophil count after SBP treatment. Conclusion: NLR and CAR can be used as quick, cheap, and applicable markers of the response of treatment in SBP patients.

show abstract

Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores

Cited by 19 publications

References 23 publications

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis

Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis

Blood Neutrophil / Lymphocyte Ratio and C –Reactive Protein / Albumin Ratio as Markers of Response for Treatment of Spontaneous Bacterial Peritonitis

Contact Info

Product

Resources

About