Presenting hypertension, burn injury, and mortality in combat casualties

Davidson, Anders J.; Ferencz, Sarah-Ashley E.; Sosnov, Jonathan A.; Howard, Jeffrey T.; Janak, Jud C.; Chung, Kevin K.; Stewart, Ian J.

doi:10.1016/j.burns.2017.07.023

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…The study found that the relationship between presenting MAP and mortality was U shaped with the highest rates of mortality on either end of the spectrum. Mortality from patients with higher initial MAP was closely associated with burns (42). Mbiine et al (43) conducted a cohort study investigating the prevalence of organ dysfunction and mortality of intra-abdominal HTN among severely burned patients.…”

Section: Discussionmentioning

confidence: 99%

The Risks of First Onset Primary Hypertension Diagnosis in Thermal-Injured Patients

Efejuku,

Wolf,

Song

et al. 2024

Shock

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INTRODUCTION Hypertension (HTN) is a prevalent condition in the United States and leads to an increased risk of developing various comorbidities. However, the impact of new-onset hypertension following severe burns on patient outcomes is not known. We posit that hypertension onset after severe burn is associated with increased risk of developing comorbidities and mortality. METHODS Using the TriNetX database, burned patients diagnosed with essential hypertension after injury were compared to those who did not develop hypertension; neither had prior hypertension. Each cohort was grouped by sex, percent total body surface area (TBSA) burned, and age, then propensity-matched for sex, race, ethnicity, and lab values. Outcomes assessed were acute kidney injury (AKI), hyperglycemia, heart failure, myocardial infarction (MI), and death. RESULTS Those diagnosed with hypertension following severe burn were 4.9 times more likely to develop AKI, 3.6 times for hyperglycemia, 5.3 times for heart failure, 4.7 times for acute MI, and 1.5 times for mortality. Sex analysis shows that men were at greater risk for AKI (1.5 times), heart failure (1.1 times), and death (1.4 times). Women were 1.3 times more likely to develop hyperglycemia. Percent TBSA burned grouping showed increased risk for all outcomes with increasing severity. Age grouping indicated an elevated risk of developing AKI, heart failure, acute MI, and death. CONCLUSION New onset hypertension diagnosis in severely burned patients is associated with acute kidney injury, heart failure, acute MI, and death. Overall, males, older patients, and those with a higher % TBSA burned are at a higher risk of developing these comorbidities.

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Section: Discussionmentioning

confidence: 99%