Presenting features of Rhodesian sleeping sickness patients in the Lambwe Valley, Kenya

Haemato-Clinical Changes in Pregnant and Non-Pregnant Rats, Rattus rattus Linnaeus, 1758 under Parasitic Stress

“…value of total serum cholesterol was reported to be significantly (P<0.05) lower in the infected group than that in the control group by the authors. These results are also in conformity with those of Wellde et al (1989) and Katunguka-Rwakishaya et al (1992) in T. rhodesiense infection of cattle and T. congolense infection of sheep. However, the observations of Adamu et al (2008) differ from those of Diehl & Risby (1974) and Rouzer & Cerami (1980) in T. gambiense and T. brucei infected rabbits, respectively.…”

“…Elevations in the TSP of monkeys after infection support earlier observations in T. rhodesiense infection of man (Wellde Chumo et al, 1989) and cattle (Wellde Reardon et al, 1989) and in goats infected with T. congolense (Witola andLovelace, 1997, Ndoutamia et al, 2002). Ahmed et al (2004) reported that the mean of total serum proteins in the normal camels was 7.381 ± 0.048 g/dl whereas, the corresponding value in haemoparasitized group was 6.831 ± 0.270 g/dl.…”

Serum Arginase, a Biomarker of Treatment Efficacy in Human African Trypanosomiasis

“…The origin of this increase has not yet been elucidated. The increase in arginase did not reflect hemolysis, since hemolysis serum markers were not found, and did not result from liver injury, since HAT patients did not exhibit any increase in the alanine amino transferase and aspartate amino transferase levels compared to healthy controls, a finding consistent with previous studies (9,10). In trypanosome-infected mice, the arginase activity increases in macrophages, the main producers of arginase (11).…”

Human African trypanosomiasis in endemic populations and travellers

“…rhodesiense HAT is classically described as an acute disease progressing to second stage within a few weeks and death within 6 months [26]. The clinical presentation is similar, but trypanosomal chancres are more frequently seen (5-26%) [27][28][29][30][31], the localisation of enlarged lymph nodes is rather submandibular, axillary and inguinal than nuchal, and oedemas are more frequently observed [28,32]. However, recent descriptions of the clinical presentation show a high variability in different foci [27,33], possibly due to different strains [34].…”