Presenting features of inflammatory bowel disease in Great Britain and Ireland

Sawczenko, A

doi:10.1136/adc.88.11.995

Cited by 407 publications

(364 citation statements)

References 22 publications

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“…However, children may also have less specific symptoms of abdominal pain, anaemia, or lethargy. In a large cohort of British children (n=172) newly diagnosed with UC, diarrhoea was seen in 72%, bleeding in 84%, pain in 62%, weight loss in 31%, and lethargy in 12% (Sawczenko et al 2003). Arthropathy, nausea and secondary amenorrhoea were seen less commonly.…”

Section: Presentation Patterns Of Ucmentioning

confidence: 99%

“…EIM were noted in 285 of a cohort of 1009 newly diagnosed patients with IBD -most of these occurred within the first 12 months after diagnosis (Dotson et al 2011). In a cohort of 211 children with UC from the UK, 1 had skin manifestations and 5 had liver disease at diagnosis (Sawczenko et al 2003). Several studies of large paediatric cohorts have illustrated key phenotypic features of UC.…”

Section: Phenotypic Features Of Ucmentioning

confidence: 99%

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Ulcerative Colitis in Children and Adolescents

Day¹,

Lemberg²

2011

Ulcerative Colitis - Treatments, Special Populations and the Future

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Section: Presentation Patterns Of Ucmentioning

confidence: 99%

Section: Phenotypic Features Of Ucmentioning

confidence: 99%

Ulcerative Colitis in Children and Adolescents

Day¹,

Lemberg²

2011

Ulcerative Colitis - Treatments, Special Populations and the Future

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“…The rate of growth impairment in pediatric IBD at diagnosis varies with the type of disease (CD vs. ulcerative colitis [UC]), gender, and the time of diagnosis [3][4][5][6][7][8][9][10][11]. Apparently, the age and pubertal stage at diagnosis are key factors for growth potential.…”

Section: Definition and Prevalencementioning

confidence: 99%

Impact of Therapeutic Strategies on Growth in Pediatric Inflammatory Bowel Disease

Shamir¹

2014

J Clin Cell Immunol

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Growth retardation is a common complication of pediatric inflammatory bowel disease (IBD), which may have long term effects on final adult height and carries significant social and psychological implications. Etiology may be multifactorial including undernutrition, metabolic dysregulation, inflammatory impact on hormonal growth axis and the effect of drugs such as glucocorticoids. Control of disease activity and minimizing the need for corticosteroid therapy are necessary measures in order to facilitate normal growth. However, in many cases these strategies are not sufficient. Currently, there is inconsistent evidence regarding the efficacy of available therapeutic agents to induce long-term effect on growth. The new era of biologic therapies which carries a greater potential to achieve mucosal healing, holds promise for better growth even in children with severe growth impairment. It becomes apparent that prompt recognition of growth impairment combined with aggressive tailored therapeutic approach may offer the best chance for catch-up growth. This review will discuss the definition, prevalence and mechanism of growth retardation in children with IBD and highlight the specific benefits of current therapeutic strategies.

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“…Genel popülasyonda Crohn hastal›¤›n›n ayn› ailenin farkl› flah›slar›nda görülme s›kl›¤› %5-20 aras›nda de¤ifl-mektedir (7,9).…”

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