Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Abstract

Key PointsQuestionWhat are the characteristics, clinical presentation, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in the US?FindingsIn this case series that included 5700 patients hospitalized with COVID-19 in the New York City area, the most common comorbidities were hypertension, obesity, and diabetes. Among patients who were discharged or died (n = 2634), 14.2% were treated in the intensive care unit, 12.2% received invasive mechanical ventilation, 3.2% were treated with kidney replacement therapy, and 21% died.MeaningThis study provides characteristics and early outcomes of patients hospitalized with COVID-19 in the New York City area.

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

“…Acute kidney injury (AKI) has been reported in > 20% of critically ill or deceased COVID-19 patients, a percentage that is consistent in studies from China [136], Italy [137] and United States [10]. It is important to note that AKI, proteinuria, and hematuria have been independently associated with a higher risk of death in COVID-19 patients [138].…”

“…Indeed, the diagnosis of diabetes in a cohort of patients with COVID-19 infection evidenced a sub-group of patients with a 2.26-fold higher risk of experiencing adverse disease outcome analyses [150]. Additionally, patients with obesity and/or glucose intolerance seem to be particularly vulnerable to COVID-19 [10,148,153,154]. Unfortunately, no data are hitherto available on anti-diabetic medications and glucose homeostasis in COVID-19 patients.…”

Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study

“…Besides the findings in our study, some other factors might also contribute to the mortality of COVID-19 patients, among which obesity would be a potential candidate. A recent study in the New York area showed that 41.7% of the patients were obese, and an increasing number of reports have linked obesity to more severe COVID-19 illness (35)(36)(37).…”

Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure

“…A number of therapies have been/are being investigated, but early results have been disappointing. Critically ill patients with COVID continue to die at an alarming rate-a recent case series published in JAMA reported 88.1% mortality for patients requiring mechanical ventilation in a large health care system in New York [5].…”