Presentation of New Onset Anosmia During the COVID-19 Pandemic

Hopkins, Claire; Šurda, Pavol; Kumar, Nirmal

doi:10.4193/rhin20.116

Cited by 298 publications

(342 citation statements)

References 14 publications

(15 reference statements)

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“…Chemosensitive dysfunction is now considered one of the most frequent symptoms in the early stages of coronavirus disease 2019 (Covid-19). [1][2][3][4][5][6][7][8][9][10][11] Objective psychophysical evaluation is challenging because of logistical and safety problems. Consequently, as of 1 July 2020, only six retrospective psychophysical studies have been published, [12][13][14][15][16][17] and only three of them investigate both olfactory and gustatory functions.…”

Section: Introductionmentioning

confidence: 99%

Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study

et al. 2020

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Background The long-term recovery rate of chemosensitive functions in coronavirus disease 2019 patients has not yet been determined. Method A multicentre prospective study on 138 coronavirus disease 2019 patients was conducted. Olfactory and gustatory functions were prospectively evaluated for 60 days. Results Within the first 4 days of coronavirus disease 2019, 84.8 per cent of patients had chemosensitive dysfunction that gradually improved over the observation period. The most significant increase in chemosensitive scores occurred in the first 10 days for taste and between 10 and 20 days for smell. At the end of the observation period (60 days after symptom onset), 7.2 per cent of the patients still had severe dysfunctions. The risk of developing a long-lasting disorder becomes significant at 10 days for taste (odds ratio = 40.2, 95 per cent confidence interval = 2.204–733.2, p = 0.013) and 20 days for smell (odds ratio = 58.5, 95 per cent confidence interval = 3.278–1043.5, p = 0.005). Conclusion Chemosensitive disturbances persisted in 7.2 per cent of patients 60 days after clinical onset. Specific therapies should be initiated in patients with severe olfactory and gustatory disturbances 20 days after disease onset.

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Section: Introductionmentioning

confidence: 99%

Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study

et al. 2020

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“…Viral infections are common causes of olfactory loss, and tran sient loss is likely under-reported. 5 Over the last 2 months, an increase of sudden isolated anosmia incidence, with or without taste loss, was reported. In this study chemosensitive dysfunction appeared in high percentage of the COVID-19 positive patients, 89.23% of patients had smell dysfunction and 83.08 had taste dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…However, other studies reported this gender percentage. [5][6][7][8] Most cases were mild, followed by moderate, then total anosmia and or taste loss. There must recognition of the patient felling to have chemosensitive disorders and the real presence of such dysfunction, i.e.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Recovery of Chemosensitive Dysfunction in Covid-19 Positive Patients

Al-Zaidi

Badr²

2020

Preprint

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Abstract Background: the objective of this study is to find the incidence of chemosensitive dysfunction in COVID-19 positive patients and its recovery.We collected the data from Sixty-five patients, all Covid-19 positive, quarantined in hospital between 5.4.2020 and 17.5.2020, by a questionnaire distributed the quarantine ward.Results: Smell dysfunction appeared in (89.23%) with or without other symptoms of COVID-19. (39.66%) had the sense of smell recovered. Taste dysfunction was found in (83.08%) patients with other COVID-19 symptoms. only (29.63%) of them recovered. The recovery took 1-3 weeks, most cases within 1 week or less. As the only symptom before COVID-19 confirmation, (18.46%) and (15.38%) had smell dysfunction and taste dysfunction respectively. Most of the chemosensitive dysfunction affected the 4th decade of age.Conclusion: Chemosensitive dysfunction is associated with COVID-19, and may be the only presenting symptom of the disease. This makes the ENT doctors in the first line of contact with corona virus. Further objective studies are required to cover chemosensitive dysfunctions, as the recognition of this dysfunction may help the diagnosis of COVID-19, and prevent the spread of this disease.

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“…2 The prevalence of OD may vary regarding the clinical setting, with rates of total loss of smell as high as 70% in patients with mild COVID-19 form. 2,4,5 The prevalence of OD in moderate-to-critical COVID-19 forms was poorly investigated. Moreover, there is, to date, a paucity of studies prospectively studying the recovery rates of smell sense in COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Recovery of Olfactory Dysfunction in 1,363 patients with coronavirus disease 2019: A Multicenter Longitudinal Study.

Lechien

Chiesa‐Estomba

Beckers³

et al. 2020

Preprint

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Abstract Olfactory dysfunction (OD) is a key symptom of coronavirus disease 2019 (COVID-19). Currently, a few data are available about the recovery of OD after the infection resolution. In this study, we investigated both prevalence and recovery rate of OD with subjective and objective clinical tools in 2,581 patients. First, our data showed that the prevalence of OD was significantly higher in mild form (85.9%) compared with moderate-to-critical forms (4.5-9.7%; p=0.001). Second, focusing on patients with OD who completed the 2-month follow-up period (N=1,363), we observed that 328 patients (24.1%) did not subjectively recover olfaction 60 days after the onset of the dysfunction. The mean duration of self-reported OD was 21.6±17.9 days. Third, the objective olfactory evaluations performed on a subset of patients (N=233) reported hyposmia or anosmia in 54.7% and 36.6% of mild and moderate-to-critical forms, respectively (p=0.001). At the end of follow-up, 15.3% of anosmic/hyposmic patients did not objectively recover olfaction. The higher baseline severity of objective olfactory evaluations was strongly predictive of persistent OD (p<0.001). OD disappeared in 75% to 85% of patients regarding self-reported or objective olfactory evaluations.

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Presentation of New Onset Anosmia During the COVID-19 Pandemic

Cited by 298 publications

References 14 publications

Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study

Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study

Incidence and Recovery of Chemosensitive Dysfunction in Covid-19 Positive Patients

Prevalence and Recovery of Olfactory Dysfunction in 1,363 patients with coronavirus disease 2019: A Multicenter Longitudinal Study.

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