Presentation of a needle for direct or percutaneous myocardium stem cells injection

Abstract

The instrument has a locking mechanism and is composed of an external needle with blunt tip, with multiple 0.5 mm diameter holes. Internally it is fitted with a mandrill needle, which can be mobilized inside occluding or releasing the lateral holes. The procedure for producing micro lesions is done by exchanging the blunt mandrill for a brush-mandrill, provided with micro bristles that are structurally designed to fill the holes with small exteriorization of bristles. As an option to brush mandrill there is a second self-expandable feather shaped mandrill.Descriptors: Stem cells. Myocardial infarction. Biopsy. Myocardium. ResumoO instrumento tem um mecanismo de bloqueio e é composto por uma agulha externa de ponta romba com vários furos de diâmetro de 0,5 mm. Internamente é equipada com uma agulha de mandril, que pode ser mobilizada ocluindo ou liberando os orifícios laterais. O procedimento para a produção de microlesões é feito por meio da troca do mandril de ponta romba por um mandril escova provido de microcerdas metálicas estruturalmente concebidas para preencher os orifícios com a exteriorização das pequenas cerdas. Como alternativa para mandril escova há um segundo mandril autoexpansível com o formato de uma pequena pena.Descritores: Células-tronco. Infarto do miocárdio. Biópsia. Miocárdio.

Occurrence of Bruise, Hematoma, and Pain in Upper Blepharoplasty Using Blunt-Needle vs Sharp-Needle Anesthetic Injection in Upper Blepharoplasty

“…However, the complications observed with this type of needle, such as bleeding, hematoma, and bruising greatly favor using blunt needles for this procedure. [8][9][10] Blunt needles have been considered easier to use and less likely than sharp ones to produce bleeding because of inadvertent penetration of arteries or adjacent vital structures. Accordingly, blunt needles are used to reduce the complications resulting from the use of sharp ones, which include bleeding, bruising, blood vessel impalement and subsequent intravascular injection and hemorrhage.…”

“…These results are also consistent with results from previous studies, where fewer complications were observed from blunt needles than from sharp needles. [8][9][10] It has been noticed that in some patients undergoing a second upper blepharoplasty procedure, it was difficult to apply local anesthesia by using the blunt needle due to the scar formation from the previous surgery. In fact, it may be easier to puncture and inject the anesthesia by using a sharp needle in scar formations.…”

“…The practice of using sharp needles for local anesthesia injections in the upper blepharoplasty procedure is widespread. However, the complications observed with this type of needle, such as bleeding, hematoma, and bruising greatly favor using blunt needles for this procedure …”

“…Furthermore, for the upper blepharoplasty procedure, local anesthesia injections with blunt needles is also less likely to produce bleeding and hematoma than sharp needles. These results are also consistent with results from previous studies, where fewer complications were observed from blunt needles than from sharp needles …”

Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

“…Their optimum design of a curved needle with side holes gave a 3-fold increase in retention compared with a straight needle with end-hole. Soubihe et al [92] also proposed a novel injection needle, with a blunt tip and multiple 0.5 mm diameter holes and with a brush-mandrill to make micro-lesions and prime the cardiac tissue to receive the cells.…”