Presentación de un nuevo caso de adenocarcinoma de células claras uretral y su manejo quirúrgico

Junquera, J.M. Abascal; Rosell, L. Cecchini; Calvo, R. Martos; Lacambra, C. Salvador; Doménech, Ana; Torres, Izquierdo; Robles, J. Morote

doi:10.1016/s0210-4806(07)73657-4

Cited by 6 publications

(4 citation statements)

References 10 publications

(6 reference statements)

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“… Zaviačič and associates [ 18 ] had reported a neoplasm with similar histological appearance and immunohistochemical features as adenocarcinoma of Skene's paraurethral gland and ducts. Their aforementioned findings would support the postulate of Abascal Junquera and associates [ 11 ] that the female clear cell adenocarcinoma arises from the paraurethral duct. Nevertheless, it would seem that female urethral adenocarcinoma has more than one tissue of origin with minority arising from the Skene's glands as suggested by Dodson and associates [ 19 ].…”

Section: Literature Reviewsupporting

confidence: 79%

“…Their aforementioned findings would support the postulate of Abascal Junquera and associates [ 11 ] that the female clear cell adenocarcinoma arises from the paraurethral duct. Nevertheless, it would seem that female urethral adenocarcinoma has more than one tissue of origin with minority arising from the Skene's glands as suggested by Dodson and associates [ 19 ].…”

Section: Literature Reviewsupporting

confidence: 79%

“…Most of the data on CCAU have been obtained from case reports and case series [ 1 , 3 , 10 ]. CCAU mostly affects females and up to half of the cases develop in urethral diverticulum [ 3 , 11 , 12 ].…”

Section: Literature Reviewmentioning

confidence: 99%

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Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Venyo

2015

International Journal of Surgical Oncology

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Background. Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. Aims. To review the literature on CCAU. Methods. Various internet databases were used. Results/Literature Review. (i) CCAU occurs in adults and in women in the great majority of cases. (ii) It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii) It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv) It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v) CCAU is aggressive with low 5-year survival rates. (vi) There is no consensus opinion of treatment options that would improve the prognosis. Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

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Section: Literature Reviewsupporting

confidence: 79%

Section: Literature Reviewsupporting

confidence: 79%

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Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Venyo

2015

International Journal of Surgical Oncology

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“…With the development of laparoscopic equipment, laparoscopic radical cystectomy with urinary diversion has become feasible and provides many intraoperative and postoperative advantages over the traditional open approach [9]. A review of the literature found only one reported case of the laparoscopic approach in patients with a urethral tumor [9]. However, laparoscopic surgery in this setting of adenocarcinoma arising from the urethral diverticulum has not previously been reported in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Radical Cystourethrectomy in a Patient with Adenocarcinoma of the Female Urethral Diverticulum

Lee

et al. 2010

Korean J Urol

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Adenocarcinomas arising in the female urethra have been rarely reported. Here we report a case of laparoscopic radical cystourethrectomy with incontinent urinary diversion in a patient with adenocarcinoma in the urethra and bladder. A 60-year-old female presenting with a history of recurrent cystitis and painless hematuria was referred to our facility with voiding difficulty and a urethral mass. Radiologic evaluation showed an enhanced mass in the urethra and bladder neck. Cystoscopic biopsy of the mass in the bladder neck revealed an adenocarcinoma. Laparoscopic radical cystourethrectomy with anterior vaginal wall excision followed by extracorporeal incontinent urinary diversion was performed. Primary carcinomas arising in a urethral diverticulum have rarely been reported and account for only 5% of all urethral malignancies [1]. Most of these tumors arise from squamous or transitional cells, and only 20% are adenocarcinomas of unknown origin.Because of the rarity of such tumors, a treatment strategy has not been established, but radical cystourethrectomy with pelvic lymph node dissection and urinary diversion appears to be the most beneficial modality for nonmetastatic disease. Many authors have reported on an open approach; however, we performed laparoscopic radical cystourethrectomy with bilateral pelvic lymph node dissection and anterior vaginal wall excision followed by ileal urinary diversion with a minimal abdominal incision. CASE REPORTA 60-year-old female with a history of recurrent cystitis and painless gross hematuria for 3 years was referred to our institution complaining of intermittent urinary retention. The patient had undergone a radical hysterectomy with bilateral salpingo-oophorectomy due to squamous cell type cervical cancer 20 years ago. Physical examination revealed a firm mass on the anterior vaginal wall. Urine cytology was nonspecific. Serum CEA and CA 19-9 were within normal limits. During cystourethroscopy, a papillary growing tumor was found at the bladder neck (Fig. 1). We found no definite mass lesion during urethrography; however, a urethral narrowing was revealed. Magnetic resonance imaging (MRI) showed a urethral mass invading the base of the bladder and the anterior vaginal wall with no pelvic lymph node enlargement. The mass showed homogeneous, low signal intensity on T1-weighted images and inhomogeneous contrast enhancement after gadolinium administration. On T2-weighted images, the mass showed high signal intensity surrounded by a low signal intense rim (Fig. 2).A fan-shaped four-port laparoscopic transperitoneal approach was performed (one 10 mm port placed at 10 mm above the umbilicus [camera], one 12 mm right pararectal trocar, one 12 mm trocar placed laterally in the right lower quadrant [assistant port], and one 5 mm trocar placed between the left anterior iliac spine and the umbilicus).Mild adhesion was observed around the ureter. After ureteral dissection, we clamped the ureter close to the ureterovesical junction by using a Hem-o-Lok clip and performed a frozen biopsy....

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Adenocarcinoma de células claras uretral intradiverticular. Presentación de un nuevo caso en una mujer

Cruz-Ruiz

Pozo-García

Gené-Heym

et al. 2010

Actas Urológicas Españolas

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El cistadenoma o quiste multilocular de la pró stata es una lesió n rara, que se confunde histopatoló gicamente con la hiperplasia nodular quística (hiperplasia benigna) 1 y debe diferenciarse de otras lesiones quísticas de la pró stata como los quistes simples, los restos müllerianos, el carcinoma quístico y el cistadenocarcinoma 2,3 . Todos los pacientes descritos en la bibliografía mostraban síntomas obstructivos; la hematuria y los síntomas generales no fueron habituales. Puede alcanzar tamañ os grandes (cistadenoma multilocular gigante), ya sea en la misma pró stata o como lesiones con pedículo prostático en otras áreas de la pelvis, entre el recto y la vejiga, haciendo necesarias, en ocasiones, intervenciones muy extensas, incluyendo las derivaciones urinarias 4,5 . Es una lesió n benigna, aunque puede recurrir si se extirpa de forma incompleta.

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Presentación de un nuevo caso de adenocarcinoma de células claras uretral y su manejo quirúrgico

Cited by 6 publications

References 10 publications

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

Laparoscopic Radical Cystourethrectomy in a Patient with Adenocarcinoma of the Female Urethral Diverticulum

Adenocarcinoma de células claras uretral intradiverticular. Presentación de un nuevo caso en una mujer

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