Present Yourself! By MHC Class I and MHC Class II Molecules

Rock, Kenneth L.; Reits, Eric; Neefjes, Jacques

doi:10.1016/j.it.2016.08.010

Cited by 590 publications

(532 citation statements)

References 130 publications

Supporting

Mentioning

485

Contrasting

Unclassified

Order By: Relevance

“…These 2 report conclusive evidence that thunderstorms can induce nuclear reactions in the atmosphere. For example, the authors find that a thunderstorm can generate a high-energy γ-ray that knocks a neutron out of a nitrogen-14 nucleus, creating an unstable nitrogen-13 isotope.…”

Section: E O N I D B a B I C Hmentioning

confidence: 65%

See 1 more Smart Citation

Machinery that guides immunity

Ploegh¹

2017

Nature

View full text Add to dashboard Cite

show abstract

Section: E O N I D B a B I C Hmentioning

confidence: 65%

“…However, these processes have been difficult to confirm experimentally. On page 481, Enoto et al 2 report the first conclusive observational evidence for thunderstorm-produced nuclear reactions -with implications for our understanding of Earth's atmosphere and isotopic composition.…”

Section: E O N I D B a B I C Hmentioning

confidence: 99%

Machinery that guides immunity

Ploegh¹

2017

Nature

View full text Add to dashboard Cite

show abstract

“…The presence of additional positive and negative regulators, the existence of different CD74 isoforms, mechanisms of cross‐presentation, alter MHC trafficking within the intracellular compartments and affect the antigen presentation process. In addition, phosphorylations, ubiquitinations, sumoylations and glycosylations evoke different behaviours of the above‐described molecules . The CD4 + subpopulation of T‐cells plays the central role in immune function.…”

Section: Introductionmentioning

confidence: 99%

Soluble major histocompatibility complex molecules in immune regulation: highlighting class II antigens

Bakela

Athanassakis

2017

Immunology

View full text Add to dashboard Cite

SummaryThe involvement of major histocompatibility complex (MHC) antigens in the development and regulation of immune response has been well defined over the years, starting from maturation, antigenic peptide loading, migration to the cell membrane for recognition by the T-cell receptor and recycling for immune response cessation. During this intracellular trafficking, MHC antigens find a way to be excreted by the cells, because they can be found as soluble MHC class I (sMHC-I) and class II (sMHC-II) molecules in all body fluids. Although secretion mechanisms have not been sufficiently studied, sMHC molecules have been shown to display important immunoregulatory properties. Their levels in the serum have been shown to be altered in a variety of diseases, including viral infections, inflammation, autoimmunities and cancer, etc. while they seem to be involved in a number of physiological reactions, including maintenance of tolerance, reproduction, as well as mate choice vis-a-vis species evolution. The present review aims to present the thus far existing literature on sMHC molecules and point out the importance of these molecules in the maintenance of immune homeostasis.

show abstract

“…Both CD4 + and CD8 + T cells use their T‐cell receptors to recognize peptide antigens presented by HLA class II and class I, respectively. CD8 + T‐cell epitopes derive from proteins within the cell which are digested by the proteasome, trimmed, and loaded onto HLA class I before being transported to the cell's surface for scrutiny by CD8 + T cells . Epitopes recognized by CD4 + T cells derive from exogenous antigens that are taken up by professional antigen presenting cells where they are degraded by lysosomal proteases .…”

Section: Introductionmentioning

confidence: 99%

Shuffling peptides to create T‐cell epitopes: does the immune system play cards?

Mannering

Elso

et al. 2017

Immunol Cell Biol

View full text Add to dashboard Cite

For a long time, immunologists have believed that classical CD4 and CD8 T cells recognize peptides (referred to as epitopes), derived from protein antigens presented by MHC/HLA class I or II. Over the past 10-15 years, it has become clear that epitopes recognized by CD8, and more recently CD4 T cells, can be formed by protein splicing. Here, we review the discovery of spliced epitopes recognized by tumor-specific human CD8 T cells. We discuss how these epitopes are formed and some of the unusual variants that have been reported. Now, over a decade since the first report, evidence is emerging that spliced CD8 T-cell epitopes are much more common, and potentially much more important, than previously imagined. Recent work has shown that epitopes recognized by CD4 T cells can also be formed by protein splicing. We discuss the recent discovery of spliced CD4 T-cell epitopes and their potential role as targets of autoimmune T-cell responses. Finally, we highlight some of the new questions raised from our growing appreciation of T-cell epitopes formed by peptide splicing.

show abstract

Present Yourself! By MHC Class I and MHC Class II Molecules

Cited by 590 publications

References 130 publications

Machinery that guides immunity

Machinery that guides immunity

Soluble major histocompatibility complex molecules in immune regulation: highlighting class II antigens

Shuffling peptides to create T‐cell epitopes: does the immune system play cards?

Contact Info

Product

Resources

About