The microstructure and the strength of high pressure torsion processed V-5Cr-5Ti alloy are investigated by X-ray line profile analysis and microhardness testing. High pressure torsion has been applied at 4 and 8 GPa with 0.25, 0.5, 1, 2, 4 and 8 rotations. The X-ray beam of the high angular resolution diffractometer, dedicated for line profile analysis, has a footprint of about 200 m1.5 mm on the specimen. The diffraction patterns have been measured in the center, at half radius and close to the edge of the specimens. This technique has provided a large number of data of the microstructure and hardness as a function of strain up to about 300. The dislocation density determined by X-ray line broadening is correlated and discussed in terms of the strength of the alloy using the Taylor equation.