Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

Ajani, Olayinka O.

doi:10.1016/j.ejmech.2014.08.034

Cited by 100 publications

(34 citation statements)

References 237 publications

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“…A wide range of quinoxaline derivatives has been reported in the literature due to their relevant biological activity [9] and applications in technological fields [10]. In addition, quinoxalines are found as interesting nitrogenated ligands for coordination chemistry [11,12].…”

mentioning

confidence: 99%

Ascorbic acid-based quinoxaline derivative as a chromogenic chemosensor for Cu 2+

Silva

Costa

Freitas

et al. 2016

Inorganic Chemistry Communications

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mentioning

confidence: 99%

Ascorbic acid-based quinoxaline derivative as a chromogenic chemosensor for Cu 2+

Silva

Costa

Freitas

et al. 2016

Inorganic Chemistry Communications

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“…4(3H)-Quinazoline derivatives possess a broad spectrum of biological activities and have been identified as antidiabetic and CNS depressants (Ding et al, 2004). Due to the existence of microorganisms' resistance phenomenon to drugs currently available in the market and consistent increase in the outbreak of new diseases, it is highly imperative and necessary to continuously design and prepare novel heterocyclic scaffolds which display improved druggability relevance for medicinal research (Ajani, 2014). Therefore, the main goal of this review herein is to harness the valuable updated information in the medicinal applications and pharmacological expertise of quinazoline motifs so as to unfold novel routes toward active targets in drug development.…”

Section: Justification For Expository Study On Quinazoline Derivativesmentioning

confidence: 99%

“…In comparison with our earlier review, quinazoline is an heterocycle which belongs to benzodiazine family with its heteroatomic nitrogen located at 1-and 3-positions (Ajani, 2014). Evolution of quinazolines began only with discovery of febrifugine, a 'quinazolinone alkaloid", which was isolated from the Chinese plant Aseru (Dichroa febrifuga Lour) and was reported to possessing antimalarial potential.…”

Section: Introductionmentioning

confidence: 99%

Quinazoline pharmacophore in therapeutic medicine

Ajani

Aderohunmu

Umeokoro

et al. 2016

Bangladesh J Pharmacol

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This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic targets. It traverses numerous biological potentials of quinazoline in the contemporary time to allow researchers' unhindered access to the beneficial role of quinazoline in fighting infectious diseases for future drug discovery. This work provides broad overview of medicinal survey of quinazoline chemistry valuable in the discovery of more efficient clinical trials and to summarize the most promising molecular targets for drug design. Article Info

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“…Some derivatives are bioactive and are used as antimicrobial, anti-inflammatory, antimalarial, anticancer and antidepressant compounds [1,2]. Others are for example employed as organic dyes [3], electroluminescent materials [4], and organic semiconductors [5].…”

Section: Introductionmentioning

confidence: 99%

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

et al. 2018

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2,3-Diphenylated quinoxaline, pyrido[2,3-b]pyrazine and 8-bromopyrido[3,4-b]pyrazine were halogenated in deprotometalation-trapping reactions using mixed 2,2,6,6-tetramethyl piperidino-based lithium-zinc combinations in tetrahydrofuran. The 2,3-diphenylated 5-iodo- quinoxaline, 8-iodopyrido[2,3-b]pyrazine and 8-bromo-7-iodopyrido[3,4-b]pyrazine thus obtained were subjected to palladium-catalyzed couplings with arylboronic acids or anilines, and possible subsequent cyclizations to afford the corresponding pyrazino[2,3-a]carbazole, pyrazino[2′,3′:5,6] pyrido[4,3-b]indole and pyrazino[2′,3′:4,5]pyrido[2,3-d]indole, respectively. 8-Iodopyrido[2,3-b] pyrazine was subjected either to a copper-catalyzed C-N bond formation with azoles, or to direct substitution to introduce alkylamino, benzylamino, hydrazine and aryloxy groups at the 8 position. The 8-hydrazino product was converted into aryl hydrazones. Most of the compounds were evaluated for their biological properties (antiproliferative activity in A2058 melanoma cells and disease-relevant kinase inhibition).

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Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

Cited by 100 publications

References 237 publications

Ascorbic acid-based quinoxaline derivative as a chromogenic chemosensor for Cu 2+

Ascorbic acid-based quinoxaline derivative as a chromogenic chemosensor for Cu 2+

Quinazoline pharmacophore in therapeutic medicine

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

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