Present Status of Gold Therapy for Rheumatoid Arthritis

Gold-specific T cells in rheumatoid arthritis patients treated with gold.

“…However, in up to one-third of the patients treatment has to be stopped because of toxicity (8). The most common Dr. Romagnoli's present address is National Institutes ofHealth, Building 10 Receivedfor publication 6 March 1991 and in revisedform 29 July 1991. toxic effects are delayed type hypersensitivity reactions involving the skin and the mucous membranes (9).…”

Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy

“…T' issue distribution of gold, on the other hand, has been adequately studied only in animals (7,8) Submitted for publication Apr 6, 1971; accepted June 21, 1971. tissues has never been systematically measured. There are scanty reports of gold levels in human skin, synovium, synovial fluid, etc, but methods of gold analysis were relatively insensitive and some of the patients studied had received only one injection of a radioactive gold-labeled compound rather than a course of gold therapy (2,3,9,10). No information is available regarding gold concentrations in internal organs or in the musculoskeletal system of a patient with rheumatoid arthritis on longterm chrysotherapy.…”

Soft Tissue Calcifications in Cord Lesions

“…Their points of predilection are in the vicinity of the hip joint, the medial femoral condyle, and the knee joint; the joints proper are never involved; the calcifications may be single or multiple. 3. These calcifications appear early after injury, progress rapidly, and develop in areas where no previous hemorrhage or infection was observed.…”