Present Status and Perspectives of Colorectal Cancer in Asia: Colorectal Cancer Working Group Report in 30th Asia-Pacific Cancer Conference

Hyodo, Ichinosuke; Suzuki, Hideo; Takahashi, Keiichi; Saito, Yoko; Tanaka, Shinji; Chiu, Han–Mo; Kim, Nam Kyu; Li, Jin; Lim, Robert; Villalon, Antonio H.; Boku, Narikazu

doi:10.1093/jjco/hyq125

Cited by 68 publications

(50 citation statements)

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“…In the United States, CRC is the third most commonly diagnosed cancer and the third highest cause of cancer-related deaths (21). The incidence of CRC has also been increasing rapidly in the Asia in the last few decades (22). Although the survival of CRC patients has dramatically improved with the progress in various therapeutic treatment applied nowadays, approximately 45% of patients will die mainly from metastatic disease in 5 years after diagnosis (23).…”

Section: Introductionmentioning

confidence: 99%

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

Zhou

Sun

et al. 2012

IUBMB Life

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SummaryPyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth in various tumors. However, the expression pattern of PKM2 in colorectal cancer (CRC) and the correlation between PKM2 expression and CRC remains unclear. The aim of this study is to investigate PKM2 expression and its possible role in CRC. We found that expression of PKM2 was increased in CRC and the increased PKM2 expression was associated with later stage and lymph metastasis of the tumors. Knockdown of PKM2 suppressed the aerobic glycolysis and decreased lactate production of colon cancer RKO cells. Knockdown of PKM2 repressed proliferation and migration of the cells. Inhibition of PKM2 suppressed xenograft tumor growth of RKO cells in vivo. These results suggest that the expression of PKM2 plays a critical role in development of CRC, and it may provide a growth advantage for colon cancer cells. Thus, PKM2 might be a potential therapeutic target for CRC.2012 IUBMB IUBMB Life, 64(9): 775-782, 2012

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Section: Introductionmentioning

confidence: 99%

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

Zhou

Sun

et al. 2012

IUBMB Life

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“…It is the third most common cancer in the UK (Cancer Research UK 2010) as well as in the USA (Jemal et al 2008). In the Asian population, there has been a rapid increase in colorectal cancer incidence (Hyodo et al 2010). Malaysia is also experiencing the same increasing trend of colorectal cancer, where it has become the most common cancer among males, superseding lung cancer (National Cancer Registry, 2006).…”

Section: Introductionmentioning

confidence: 99%

Quality of life in Malaysian colorectal cancer patients

Puteh

Saad

Aljunid

et al. 2013

Asia-Pacific Psychiatry

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IntroductionThe rapidly increasing of incidence colorectal cancer (CRC) in Malaysia and the introduction of new treatments that prolong survival advocating treatment outcome measures such as patients' quality of life (QOL) are evaluated in this study. The study aims to determine QOL in CRC patients according to cancer stage and age.MethodsA cross‐sectional study was performed from June to December 2011 at four public tertiary hospitals. The European Organization for Research and Treatment in Cancer (EORTC) Quality of Life Questionnaire Core‐30 (EORTC QLQ C‐30) questionnaire was used through face‐to‐face interview and the medical records of 160 respondents were reviewed.ResultsThe mean age of respondents was 58.47 ± 12.04 years with 57.5% of respondents being male and 42.5% female. The majority of respondents were in CRC stages III and IV. Median global health status (GHS) score was 83.33 (IQR 16.67). Sikhs and Indians had a higher median GHS score compared to other ethnicities (Kruskal–Wallis, χ2 = 12.12, p = 0.007). Emotional, cognitive and social functions were higher in respondents with earlier stage of disease (Kruskal‐Wallis, χ2 = 6.06, 6.36, 10.58, p = 0.048, 0.042, 0.005). Median pain, dyspnea, diarrhea and financial implication scores were significantly higher in advanced stage of disease (Kruskal‐Wallis, χ2 = 9.31, 6.26,6.77, 7.28, p = 0.010, 0.044,0.034,0.026). Median diarrhea score (p = 0.012) was significantly different between age groups.DiscussionEmotional, cognitive and social functions deteriorate with advanced stage of disease. Patients with advanced stage disease experience more pain, dyspnea, diarrhea and financial implications. A systematic screening program to detect cases as early as possible is essential nationwide.

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“…It is the third most common cancer in United Kingdom (Cancer Research UK, 2010) as well as in the United States of America (Jemal et al, 2008). In the Asian population, there is a rapid increase in the trend of colorectal cancer incidence (Hyodo et al, 2010). Malaysia is also experiencing the same increasing trend of colorectal cancer, where it becomes the most common cancer among males superseded lung cancer (National Cancer Registry, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…In Asia, screening with faecal occult blood test is a national policy only in Japan, Taiwan and Korea (Hyodo et al, 2010). In Malaysia, currently the awareness of the importance of CRC screening is very low especially among the general population as well as the policy makers which resulted in inadequate resources allocation for faecal occult blood test and colonoscopy and subsequently late stage of the disease at presentation.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Malaysian Colorectal Cancer Patients : A Preliminary Result

Natrah¹,

Ezat²,

Syed³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Rapidly increasing colorectal cancer (CRC) incidence in Malaysia and the introduction of cutting edge new treatments, which prolong survival, mean that treatment outcome measures meed to be evaluated, including consideration of patient's quality of life (QoL) assessment. There are limited data on QoL in CRC patients, especially in Malaysia. Therefore, this study was performed focusing on cancer stages and age groups. Methods: The cross sectional study was conducted from June to September 2011 at three public tertiary hospitalswith the EORTC QLQ C-30 questionnaire in addition to face to face interview and review of medical records of 100 respondents. Results: The mean age was 57.3 (SD 11.9) years with 56.0% are males and 44.0% females, 62% of Malay ethnicity, 30% Chinese, 7% Indian and 1% Sikh. Majority were educated up to secondary level (42%) and 90% respondents had CRC stages III and IV. Mean global health status (GHS) score was 79.1 (SD 21.4). Mean scores for functional status (physical, emotional, role, cognitive, social) rangeds between 79.5 (SD 26.6) to 92.2 (SD 13.7). Mean symptom scores (fatigue, pain, nausea/vomiting, constipation, diarrhea, insomnia, dyspnoea, loss of appetite) ranged between 4.00 (SD 8.58) to 20.7 (SD 30.6). Respondents role function significantly deteriorates with increasing stage of the disease (p=0.044). Females had worse symptoms of pain (p=0.022), fatigue (p=0.031) and dyspnoea (p=0.031). Mean insomnia (p=0.006) and diarrhea (p=0.024) demonstrated significant differences between age groups. Conclusion: QOL in CRC patients in this study was comparable to that in other studies done in developed countries. Pain, fatigue and dyspnoea are worse among female CRC patients. Given that functions deteriorates with advanced stage of the disease at diagnosis, a systematic screening programme to detect cases as early as possible is essential nationwide.

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Present Status and Perspectives of Colorectal Cancer in Asia: Colorectal Cancer Working Group Report in 30th Asia-Pacific Cancer Conference

Abstract: Further clinical cooperation is needed to optimize the management of colorectal cancer in Asia.

Cited by 68 publications

References 4 publications

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

Quality of life in Malaysian colorectal cancer patients

Quality of Life in Malaysian Colorectal Cancer Patients : A Preliminary Result

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