Present Status and Future Perspectives of Marine Actinobacterial Metabolites

Puttaswamygowda, Gurushankara Hunasanahally; Olakkaran, Shilpa; Antony, Anet; Purayil, Anupama Kizhakke

doi:10.1016/b978-0-12-816328-3.00022-2

Cited by 20 publications

(16 citation statements)

References 95 publications

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“…Similar to Proteobacteria, several studies demonstrated the great biotechnological potential of Actinobacteria, especially those belonging to the Streptomyces genus. In fact, several bioactive compounds with antimicrobial, antiviral, antiparasitic, antiprotozoal and antitumor effects have been described [ 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ]. Moreover, genomic analyses revealed some BGCs encoding for secondary metabolites, such as PKS I and III, NRPS (nonribosomal peptides), terpene and bacteriocin gene clusters from a sponge-derived Actinobacteria showing antimicrobial activities [ 108 , 109 , 110 , 111 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

et al. 2021

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Marine sponges commonly host a repertoire of bacterial-associated organisms, which significantly contribute to their health and survival by producing several anti-predatory molecules. Many of these compounds are produced by sponge-associated bacteria and represent an incredible source of novel bioactive metabolites with biotechnological relevance. Although most investigations are focused on tropical and temperate species, to date, few studies have described the composition of microbiota hosted by Antarctic sponges and the secondary metabolites that they produce. The investigation was conducted on four sponges collected from two different sites in the framework of the XXXIV Italian National Antarctic Research Program (PNRA) in November–December 2018. Collected species were characterized as Mycale (Oxymycale) acerata, Haliclona (Rhizoniera) dancoi, Hemigellius pilosus and Microxina sarai by morphological analysis of spicules and amplification of four molecular markers. Metataxonomic analysis of these four Antarctic sponges revealed a considerable abundance of Amplicon Sequence Variants (ASVs) belonging to the phyla Proteobacteria, Bacteroidetes, Actinobacteria and Verrucomicrobia. In particular, M. (Oxymycale) acerata, displayed several genera of great interest, such as Endozoicomonas, Rubritalea, Ulvibacter, Fulvivirga and Colwellia. On the other hand, the sponges H. pilosus and H. (Rhizoniera) dancoi hosted bacteria belonging to the genera Pseudhongella, Roseobacter and Bdellovibrio, whereas M. sarai was the sole species showing some strains affiliated to the genus Polaribacter. Considering that most of the bacteria identified in the present study are known to produce valuable secondary metabolites, the four Antarctic sponges could be proposed as potential tools for the discovery of novel pharmacologically active compounds.

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Section: Discussionmentioning

confidence: 99%

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

et al. 2021

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“…16 Oceans, which cover about 70% of our earth' surface, have attracted a special interest owing to their exceptionally important biodiversity. 17 To date, marine organisms have provided wide-ranging natural compounds with promising antimicrobial, antiviral, antimalarial, antitumor, antioxidant, and antiinflammatory properties. 18,19 Among them, soft corals, a group of marine invertebrates found within the coral reefs of most oceans, are a biochemical storeroom of important secondary metabolites, eg, sesquiterpenes, 20 diterpenes, 21 and sterols, 22 which are endowed with antifouling, antiviral, antitumor, and anti-inflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

<p>Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral <em>Nephthea</em> Sp. Supported by Metabolomics Analysis and Docking Studies</p>

Abdelhafez

Ali

Fahim

et al. 2020

IJN

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Background: Soft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential as source of anti-inflammatory metabolites has stimulated a growing research interest. Purpose: To investigate the anti-inflammatory potential of the soft coral, Nephthea sp., in its bulk and silver nanostructure. Metabolomics analysis of Nephthea sp., followed by molecular docking studies, was also conducted in order to explore and predict the secondary metabolites that might provide its inhibitory actions on inflammation. Materials and Methods: The petroleum ether and ethyl acetate fractions were used to synthesize silver nanoparticles. The prepared silver nanoparticles were characterized through UV-vis spectrophotometric, transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR) analyses. Testing for the anti-inflammatory activity was performed against COX-1 and COX-2. Furthermore, liquid chromatography-mass spectrometry (LC-MS) based metabolomics analysis and molecular docking were also applied. Results: A variety of secondary metabolites were identified, among them, sesquiterpenes were found to prevail. The petroleum ether and acetone fractions of Nephthea sp. showed the highest COX-2 inhibitory activities, possibly attributable to their substantial contents of terpenoids. Additionally, the green synthesized silver nanoparticles of both the petroleum ether and ethyl acetate fractions of Nephthea sp. demonstrated higher anti-COX-2 properties. Conclusion: The obtained results showed the effectiveness of non-targeted metabolomics technique in metabolic profiling of Nephthea sp., helping the search for new bioactive metabolites in future chemical studies on this soft coral. The interesting anti-inflammatory potential of the tested extracts and their nanoparticles could also be relevant to the development of new, effective anti-inflammatory agents.

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“…They can perform several important functions. Some Actinobacteria can synthesize a wide diversity of secondary metabolites, which may promote survival in highly selective environments (Fang et al, 2017;Puttaswamygowda et al, 2019;Qin et al, 2019). Several studies have highlighted the importance of temperature as a selective factor of thermo−tolerant Actinobacteria.…”

Section: Discussionmentioning

confidence: 99%

Relative Weight of Organic Waste Origin on Compost and Digestate 16S rRNA Gene Bacterial Profilings and Related Functional Inferences

et al. 2021

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Even though organic waste (OW) recycling via anaerobic digestion (AD) and composting are increasingly used, little is known about the impact of OW origin (fecal matters and food and vegetable wastes) on the end products’ bacterial contents. The hypothesis of a predictable bacterial community structure in the end products according to the OW origin was tested. Nine OW treatment plants were selected to assess the genetic structure of bacterial communities found in raw OW according to their content in agricultural and urban wastes and to estimate their modifications through AD and composting. Two main bacterial community structures among raw OWs were observed and matched a differentiation according to the occurrences of urban chemical pollutants. Composting led to similar 16S rRNA gene OTU profiles whatever the OW origin. With a significant shift of about 140 genera (representing 50% of the bacteria), composting was confirmed to largely shape bacterial communities toward similar structures. The enriched taxa were found to be involved in detoxification and bioremediation activities. This process was found to be highly selective and favorable for bacterial specialists. Digestates showed that OTU profiles differentiated into two groups according to their relative content in agricultural (manure) and urban wastes (mainly activated sludge). About one third of the bacterial taxa was significantly affected by AD. In digestates of urban OW, this sorting led to an enrichment of 32 out of the 50 impacted genera, while for those produced from agricultural or mixed urban/agricultural OW (called central OW), a decay of 54 genera over 60 was observed. Bacteria from activated sludge appeared more fit for AD than those of other origins. Functional inferences showed AD enriched genera from all origins to share similar functional traits, e.g., chemoheterotrophy and fermentation, while being often taxonomically distinct. The main functional traits among the dominant genera in activated sludge supported a role in AD. Raw OW content in activated sludge was found to be a critical factor for predicting digestate bacterial contents. Composting generated highly predictable and specialized community patterns whatever the OW origin. AD and composting bacterial changes were driven by functional traits selected by physicochemical factors such as temperature and chemical pollutants.

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Present Status and Future Perspectives of Marine Actinobacterial Metabolites

Cited by 20 publications

References 95 publications

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

<p>Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral <em>Nephthea</em> Sp. Supported by Metabolomics Analysis and Docking Studies</p>

Relative Weight of Organic Waste Origin on Compost and Digestate 16S rRNA Gene Bacterial Profilings and Related Functional Inferences

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