Present State of Yusho Patients

Urabe, Harukuni; Koda, Hiromu; Asahi, Masakazu

doi:10.1111/j.1749-6632.1979.tb56609.x

Cited by 61 publications

(18 citation statements)

References 0 publications

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“…The disease, which became known as Yusho or "rice oil disease," was first characterized by its dermal manifestations including acneform lesions, brown pigmentation of the skin, and ocular swelling. However, many Yusho patients also complained of neurological disorders including headache and memory loss as well as numbness, hypoesthesia, and neuralgia of the limbs (Urabe et al 1979).…”

Section: Historical Cohorts For Which Congener-specific Data Are Not mentioning

confidence: 99%

Effects of PCB exposure on neuropsychological function in children.

Schantz

Widholm

Rice

2003

Environ Health Perspect

452

294

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In the last decade advances in the analytic methods for quantification of polychlorinated biphenyls (PCBs) have resulted in widespread availability of congener-specific analysis procedures, and large amounts of data on PCB congener profiles in soil, air, water, sediments, foodstuffs, and human tissues have become available. These data have revealed that the PCB residues in environmental media and human tissues may not closely resemble any of the commercial PCB mixtures, depending on source of exposure, bioaccumulation through the food chain, and weathering of PCBs in the environment. At the same time, toxicological research has led to a growing awareness that different classes of PCB congeners have different profiles of toxicity. These advances in analytic techniques and toxicological knowledge are beginning to influence the risk assessment process. As the data from ongoing PCB studies assessing the mediators of neurobehavioral outcomes in children are published, the weight of evidence for PCB effects on neurodevelopment is growing. Studies in Taiwan, Michigan (USA), New York (USA), Holland, Germany, and the Faroe Islands have all reported negative associations between prenatal PCB exposure and measures of cognitive functioning in infancy or childhood. The German study also reported a negative association between postnatal PCB exposure and cognitive function in early childhood--a result that had not been found in previous studies. Only one published study in North Carolina (USA) has failed to find an association between PCB exposure and cognitive outcomes. Despite the fact that several more recent studies have used congener-specific analytic techniques, there have been only limited attempts to assess the role of specific PCB congeners or classes of congeners in mediating neurodevelopmental outcomes. From a statistical standpoint, attempts to determine the role of individual congeners in mediating outcomes are hampered by the fact that concentrations of most individual congeners are highly correlated with each other and with total PCBs. From a toxicological standpoint, these efforts are hampered by the fact that many of the PCB congeners present in human tissues have never been studied in the laboratory, and their relative potency to produce nervous system effects is unknown. More complete information on the health effects of various congeners or congener classes would allow more informed scientific and risk assessment decisions.

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Section: Historical Cohorts For Which Congener-specific Data Are Not mentioning

confidence: 99%

Effects of PCB exposure on neuropsychological function in children.

Schantz

Widholm

Rice

2003

Environ Health Perspect

452

294

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show abstract

“…(20) Exposure to PCDD can cause chloracne and liver toxicity in humans. (16,21) There is suggestive evidence of an association between increased incidence of cancer in people exposed to PCB containing substantial amounts of PCDF (22,23) and in people exposed to phenoxyacetic herbicides contaminated with PCDD, including TCDD. (24,25) Due to the inadequately defined study populations and the influences of mixed exposures, definite causal relationships between exposure and carcinogenic effects in humans remain unclear.…”

Section: Evaluation Criteriamentioning

confidence: 99%

Health hazard evaluation report: HETA-88-207-2195, Northwest Incinerator, Philadelphia, Pennsylvania.

Kinnes¹,

Bryant²

1992

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“…54 Exposure to PCDD can cause chloracne and liver toxicity in humans. 50,55 There is suggestive evidence of an association between increased incidence of cancer in people exposed to PCB containing substantial amounts of PCDF 56,57 and in people exposed to phenoxyacetic herbicides contaminated with PCDD, including TCDD. 58,59 Definite causal relationships between exposure and carcinogenic effects in humans remain unclear, however, due to the inadequately defined study populations and the influences of mixed exposures.…”

Section: B Pcdds/pcdfsmentioning

confidence: 99%

Health hazard evaluation report: HETA-86-510-2032, National Electric (Aptus), Incorporated, Coffeyville, Kansas.

1990

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Present State of Yusho Patients

Cited by 61 publications

References 0 publications

Effects of PCB exposure on neuropsychological function in children.

Effects of PCB exposure on neuropsychological function in children.

Health hazard evaluation report: HETA-88-207-2195, Northwest Incinerator, Philadelphia, Pennsylvania.

Health hazard evaluation report: HETA-86-510-2032, National Electric (Aptus), Incorporated, Coffeyville, Kansas.

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