Present-day views on surgical treatment of patients with esophageal and gastric varices

Samsonyan, E. Kh.; Kurganov, I. A.; Bogdanov, D. Yu.

doi:10.17116/endoskop201622543-48

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,26 As mentioned in clinical case reports and the instructions for use, the mean IV dose of terlipressin for the treatment and prevention of bleeding varies from 200 μg to 1000 μg. 9,10,12,13,[24][25][26] The data from the two groups show that low doses of terlipressin (200 μg) ensure significant hemostatic and vasoconstrictive effects (Table II). However, it should be taken into account that we evaluated the severity of the hemostatic effect of I).…”

Section: Discussionmentioning

confidence: 99%

“…), the drug also facilitates the dose‐dependent enhancement of procoagulant and fibrinolytic acivities 11 . Today, terlipressin is a popular blood‐saving agent used in abdominal surgery, obstetrics, and gynecology 8,12,13 . Some articles describe the benefits of terlipressin for epistaxis, 14,15 but its use in endoscopic nasal procedures has never been studied.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

et al. 2023

View full text Add to dashboard Cite

ObjectiveTo evaluate the use of terlipressin for intraoperative bleeding reduction in functional endoscopic sinus surgery (FESS).MethodsThis prospective, randomized, single‐center, single‐blinded cohort study included 74 cases of FESS performed under general anesthesia (GA). The patients were randomized into two groups: WT (without terlipressin, n = 39) and T (with 200 μg terlipressin, n = 35). Bleeding intensity (BI) was assessed using a 6‐point scale. Heart rate (HR), mean blood pressure (MBP), perfusion index (PI), and BI were recorded at 10, 30, and 60 min after surgery. A BI score ≥2 qualified as significant.ResultsThe T group had significantly higher MBP compared with the WT group, but HR values did not differ significantly. PI and BI scores were significantly reduced in the T group compared with the WT group. The risk of significant bleeding in the treatment group was 35.5 times lower (odds ratio [OR], 0.028; 95% confidence interval [CI], 0.006–0.138) at 30 min and 7.1 times lower (OR, 0.140; 95% CI, 0.049–0.402) at 60 min. The prognostic model for significant bleeding at 60 min showed that only terlipressin played a significant role in bleeding control (p < 0.05). The model predicted a 13.9‐fold decrease in significant bleeding risk in the T group.ConclusionLow doses (200 μg) of terlipressin reduced intraoperative bleeding without decreasing blood pressure during FESS under GA.Level of Evidence2 Laryngoscope, 2023

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

et al. 2023

View full text Add to dashboard Cite

show abstract

Anesthesiological Possibilities of Intraoperative Bleeding Control During Endoscopic Rhinosinusurgical Interventions

Pavlov

Polushin

Колотилов

2022

Vestn. anesteziol. reanimatol.

View full text Add to dashboard Cite

The safety and effectiveness of endoscopic rhinological operations in the treatment of chronic inflammatory diseases, as well as neoplasms of the paranasal sinuses, are largely achieved by reducing bleeding in the area of the surgical field. Even a small amount of blood can disrupt the view during endoscopy and prevent the intervention from being performed, thereby increasing the risk of complications.The review presents modern methods of reducing the risk of intraoperative bleeding under general anesthesia. Each approach has its own characteristics, therefore, the benefit-risk ratio should be assessed for each patient before choosing a specific method for controlling intraoperative bleeding.

show abstract

Terlipressin using for intraoperative bleeding reduction during endoscopic rhinosinus surgery

Arustamyan,

Pavlov,

Polushin

et al. 2024

Medicinskij sovet

View full text Add to dashboard Cite

Introduction. Endoscopic rhinosinus surgery stands out for its reduced complications and marked symptomatic improvement compared to open surgical approaches. However, local bleeding challenges may compromise the efficacy of minimally invasive procedures. Exploring terlipressin’s application in endoscopic rhinosinus surgery is a promising avenue, given its mechanism of action and successful use in obstetric and other medical practices.Aim. This study aimed to assess terlipressin’s efficacy in reducing intraoperative bleeding during endoscopic rhinosinus surgical interventions under general anesthesia.Materials and methods. A prospective randomized cohort study included 170 cases of endoscopic rhinosinus surgical interventions. The BT group (n = 89) received no terlipressin, while the T group (n = 81) had 200 mcg of terlipressin during surgery. Bleeding intensity was assessed on a 6-point scale. Heart rate, blood pressure, perfusion index, and bleeding intensity were recorded at 10th, 30th, and 60th minute into the operation (study points). Bleeding intensity ≥2 points was considered significant. Results. In the T group, mean BP was significantly higher at all study points than in the BT group. Perfusion index values in the terlipressin group were significantly lower throughout. ROC analysis highlighted perfusion index’s prognostic value at 30th and 60th minutes for predicting significant bleeding. Threshold perfusion index values associated with increased bleeding probability were 4.520 at 30th minutes and 5.040 at 60th minute. Multifactorial analysis linked intraoperative terlipressin administration to a lower likelihood of significant intraoperative bleeding.Conclusion. Intravenous terlipressin (200 mcg) effectively reduces intraoperative bleeding intensity without lowering arterial pressure during endoscopic rhinosinus surgical interventions under general anesthesia.

show abstract

Present-day views on surgical treatment of patients with esophageal and gastric varices

Cited by 3 publications

References 11 publications

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

Anesthesiological Possibilities of Intraoperative Bleeding Control During Endoscopic Rhinosinusurgical Interventions

Terlipressin using for intraoperative bleeding reduction during endoscopic rhinosinus surgery

Contact Info

Product

Resources

About