Present Day Specific Treatment of the Pneumonias

Samper, Bernardo A.; Finland, Maxwell

doi:10.1016/s0025-7125(16)36167-3

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…The experiments recorded in Table VI confirm this fact and have made it possible to deter~nine whether the potentiating effect of the viru¢ on the bacterial infection will interfere with chemotherapy. The results recorded in Table VII indicate no interference under such circumstances and are consistent with clinical experience in that pneumonia following influenza (58)(59)(60)8), 9 measles (61, 62), and dog distemper (63) all appear to respond to sulfonamide drugs.…”

Section: Discussionsupporting

confidence: 82%

Sulfonamide Chemotherapy of Combined Infection With Influenza Virus and Bacteria

Harford¹,

Smith²,

Wood³

1946

Journal of Experimental Medicine

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1. Sulfonamide chemotherapy controls the bacterial component of combined infection with influenza virus and pneumococci in rats. 2. Reinstillation of fluid (broth, physiological salt solution) into the respiratory passages of mice several days after sublethal viral infection converts the viral infection into a lethal one. 3. Sulfonamide chemotherapy controls the bacterial component of combined bacterial and viral infection of mice, produced by intrabronchial inoculation of mixtures of bacteria and sublethal or lethal doses of virus. 4. Bacterial pneumonia may be superimposed upon sublethal viral infection in mice by inhalation of fine droplets of bacterial suspension several days after inoculation of virus. Normal mice inhaling fine droplets of bacterial suspension fail to develop obvious disease. 5. Sulfonamide chemotheiapy controls bacterial pneumonia superimposed on sublethal viral infection by inhalation of fine droplets of bacterial culture. 6. The secondary bacterial penumonia does not convert the sublethal viral infection into a lethal one. 7. If another pandemic of influenza occurs, it is probable that sulfonamide chemotherapy will be valuable in the treatment of secondary bacterial pneumonia and will be effective in lowering the case fatality rate if the viral component of the infection is not severe enough by itself to cause death.

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Section: Discussionsupporting

confidence: 82%

Sulfonamide Chemotherapy of Combined Infection With Influenza Virus and Bacteria

Harford¹,

Smith²,

Wood³

1946

Journal of Experimental Medicine

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“…The interval between the onset of the 2 diseases varied. In 11 cases, the pneumonia began at about the same time or within 5 days after the influenza; in 7 others, the interval was 7 to 16 days; while in the remaining 6 cases, the onset of the pneumonia .198 Jan. 18 Dec. 11 Jan. 18 Jan. 17 Jan. 18 Dec. 22 Feb. 9 Jan. 17 Jan. 18 Jan. 11 Jan. 17 Dec. 29 Jan. 11 Jan. 17 Feb. 9 Jan. 18 Jan. 17 Jan. 11 Jan. 18 Jan. 17 Jan. 17 Jan. 17 Jan. 18 Jan. 17 Jan. 18 Jan. 18 Jan. 15 Jan. 18 Mar. 7 Jan occurred from 24 to 58 days after the first symptom of influenza.…”

Section: Serological Studies In Cases Of Epidemic Influenzaunclassified

“…Consolidation of the lungs spread 3A chart showing details of the clinical course and therapy in this case is shown elsewhere (15). The presence of virus was noted in the allantoic fluid following the primary inoculation in every instance.…”

mentioning

confidence: 91%