Presencia de altos niveles de arsénico en tejidos cardiovasculares de pacientes de áreas contaminadas en Chile

Solar, Carlos; Pizarro, Isabel; Román, Domingo; Cardiol, Rev Chil

doi:10.4067/s0718-85602012000100006

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…In this case, the tissue is seriously ill and the intimal layer has analogous thickness than the muscular layer. The concentric intimal fibrosis does not belong to the principal atherosclerotic disease damage, main causes for heart attack and is produced by age, or by the influence of chemical or immunological processes 34 . Then, appear not to be apparent that arsenic may cause necrosis in cardiovascular tissues of the man 35 .…”

Section: Ex-chmentioning

confidence: 99%

Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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SUMMARYThis study evaluated the total and main arsenic species in chicken heart tissues. The experimental study was carried out using two sets of samples. In the first one, 30-day-old chickens were exposed to sodium arsenate, using spiked drinking water. These chickens grew normally and were killed after fifty days of arsenic exposure. The second sets were edible chickens were nonexposed to sodium arsenate for a parallel study. The total arsenic and arsenic species content in the exposed samples were at least twice those in the normal edible chicken. One important aspect is the capability of the heart tissues to preconcentrate the most toxic species, arsenite, in the exposed chicken. Arsenobetaine was also detected in fat in the non exposed chicken.This study could be a way of establishing similarities and differences with humans exposed to the same As(V) species, to ascertain whether chickens can be used in arsenic metabolism evaluation and the results extrapolated to humans.

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Section: Ex-chmentioning

confidence: 99%

Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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“…Typical clinical non-cancer effects affecting the health and quality of life of people due to environmental arsenic exposure, such as vascular diseases, abnormal pigmentation, Reynard's syndrome, acrocyanosis, hyperkeratosis, finger gangrene, tongue ischemia, diabetes, thrombosis, cerebral vascular disease (particularly cerebral strokes), coronary artery occlusions, and other CVDs have been associated to the arsenic chronic exposure (17,18). However, other factors of risk like smoking, serum high levels of lowdensity lipoprotein (LDL cholesterol) and high blood pressure levels have been associated cooperatively with the coronary heart disease (CHD) or cardiovascular atherosclerotic disease in humans.…”

Section: Issn (Online)mentioning

confidence: 99%

Environmental Contamination of Arsenic and its Toxicological Impact in Cardiovascular Tissues of Patients with Coronary Heart Disease

2017

IJSR

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Background: The concentration levels of As in the Chilean II Region of Antofagasta produces non cancer health outcomes such as cardiovascular diseases and in last term heart attack. On this study, the determination of total As content and main inorganic and organoarsenic species found in three heart tissues (auricle, mammary artery and fat) and the saphenous vein of people living in the Chilean II Region, suffering coronary thrombosis has been carried out. Comparison with similar tissues of patients from other noncontaminated areas has been undertaken. Methods: Total As determination has been performed by HG-AAS and ICP-MS. For As species have been used the tandem HPLC-ICP-MS using the Hamilton PRP X100 anion column and methanol:water (1:1) extraction. Results: The auricle and in less extend the saphenous vein support the higher As concentration (mean values of 7.7 and 2.5 µg g -1 , respectively), being As(III) the predominant species. Methylation towards MMA and DMA is not a favoured mechanism. Conclusions: The presence of high total As and high As(III) species content in the auricle and saphenous vein of more contaminated people, the damage found in the saphenous vein tissue and the global characteristics of the people under study in which the As stigmas are present in all of them, suggests that As could be involved in the cardiovascular diseases.

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“…La preparación de las muestras se realizó en la "sala limpia" del laboratorio, equipada con una campana de flujo laminar (Labconco, Purifer clase II), utilizando dispositivos inertes de plástico y titanio, mortero de ágata y material quirúrgicos de acero inoxidable. Después de la eliminación de residuos, los tejidos fueron enjuagados con agua desionizada, separados como muestras unitarias y almacenados a -20 º C. Posteriormente, se determinó la CT 17 de los elementos en estudio. Además, se realizó una encuesta a estos pacientes, en las cuales se consideraron factores relacionados con el trabajo desarrollado, hábitos, lugares de residencia y permanencia en la ciudad.…”

Section: Conclusiónunclassified

Niveles De Elementos Traza en Tejidos Cardiovasculares De Pacientes Sometidos a Cirugía Cardíaca en La Región De Antofagasta, Chile

Román

Solar

Pizarro³

2013

Rev Chil Cardiol

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Results: Significant inter elemental correlations were observed for B in group E, (p<0.05), which are not present in group NE. The RA concentrarion of B in group A ranged from 24.72 to 932.03 ug/g, substancially higher than concentracion of the other elements under study. Corresponding concentrarions of B in the NE group were 25.21 to 56. 87 ug/g. Conclusion: B was the most enriched element in the exposed group, followed by As and Mn. Cu content was significantly lower in RA and LIMA from patients in the non exposed group.

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Presencia de altos niveles de arsénico en tejidos cardiovasculares de pacientes de áreas contaminadas en Chile

Cited by 5 publications

References 19 publications

Arsenic Status and Speciation in Chicken Heart Tissues

Arsenic Status and Speciation in Chicken Heart Tissues

Environmental Contamination of Arsenic and its Toxicological Impact in Cardiovascular Tissues of Patients with Coronary Heart Disease

Niveles De Elementos Traza en Tejidos Cardiovasculares De Pacientes Sometidos a Cirugía Cardíaca en La Región De Antofagasta, Chile

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