Presence of α1-Antichymotrypsin and α1-Antitrypsin in Haematopoietic and Lymphoid Tissue Cells as Revealed by the Immunoperoxidase Method

Papadimitriou, C.; Stein, H.; Papacharalampous, N

doi:10.1016/s0344-0338(80)80007-0

Cited by 57 publications

(16 citation statements)

References 16 publications

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“…This is the first report describing this association. SERPINA3 is an acute phase protein and a protease inhibitor released by the liver during inflammation and by activated endothelial cells and macrophages 55 . Cell culture experiments showed that human hepatocytes transfected with the SERPINA3 ‐51 T allele produced increased levels of the reporter gene product 55 .…”

Section: Discussionmentioning

confidence: 99%

“…SERPINA3 is an acute phase protein and a protease inhibitor released by the liver during inflammation and by activated endothelial cells and macrophages 55 . Cell culture experiments showed that human hepatocytes transfected with the SERPINA3 ‐51 T allele produced increased levels of the reporter gene product 55 . These findings suggest that increased release of this acute phase protein may impair the regulation of inflammatory responses and expose homozygous subjects to increased risk of atherogenesis and its clinical complications.…”

Section: Discussionmentioning

confidence: 99%

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Acute Myocardial Infarction and Proinflammatory Gene Variants

Licastro

Chiapelli

Caldarera

et al. 2007

Annals of the New York Academy of Sciences

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We identified four genetic risk sets for acute myocardial infarction (AMI) from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4; 316 patients and 461 healthy subjects, all Italian. Putative risk alleles are shown underlined. The sets were identified using grade-of-membership analysis. Membership scores in the sets are automatically generated for individuals. The 'low intrinsic risk' set had alleles that downregulate inflammation and cholesterol synthesis (IL6, TNF, ILl0, HMGCR). 'AMI across a broad age range' carried multiple proinflammatory alleles (IL6, TNF, IL10, SERPINA3): All 72 persons like this set were affected yet had relatively low plasma cholesterol levels. 'A subset of AMI in middle age' had numerous proinflammatory alleles (IL6, TNF, SERPINA3, IFNG, HMGCR). 'AMI after age 80' had a reduced risk set (IL6, IL10, IFNG). A total of 95% of cases had >/=50% membership in the high intrinsic risk sets. We conclude that proinflammatory gene variants taken together strongly determine an individual's risk for myocardial infarction. This information may better define the pathogenesis of myocardial infarction and identify individuals who might benefit from early interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute Myocardial Infarction and Proinflammatory Gene Variants

Licastro

Chiapelli

Caldarera

et al. 2007

Annals of the New York Academy of Sciences

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“…ACT is also found in the brain and the plasma-derived inhibitor is probably separated from the brain by the tight blood-brain barrier consisting of endothelial cells. However, brain endothelial cells have the capacity to synthesise and release cytokines and ACT (Fabry et al 1993;Papadimitriou et al 1980). Local ACT production in the brain probably plays an important role in tissue remodelling.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism in the alpha1-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations

et al. 2001

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Alpha1-antichymotrypsin (ACT: new identification SERPINA3) is a member of the serine proteinase inhibitor (serpin) gene family and biochemically has been shown to be a constituent of the senile plaques of Alzheimer's disease. We describe a polymorphism (G-->T) in the promoter region of the ACT gene with the T allele being associated with a 22% increase in the mean plasma ACT concentrations. By reporter gene studies, the T allele is consistently associated with higher mean basal expression in both the human liver cell-line Hep G2 (32%) and in a human glial cell-line T98G (30%). Following 6-h stimulation with the cytokine oncostatin-M, there was a 30-fold increase in Hep G2 and a four-fold increase in T98G cells. The T allele in the promoter region is also in almost complete linkage disequilibrium with the T allele in the signal peptide region of the ACT gene with a standardised disequilibrium coefficient (D') of 0.97; P<0.001. This is the first description of a polymorphism in the ACT gene promoter directly associated with altered gene expression.

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“…They are expressed in wound healing processes after tissue damage as well as in tissue remodeling. Alpha-ACT and -AT are found in many tumors and body fluids such as saliva, tears, milk, amniotic fluid and semen, as well as duodenal bile (194)(195)(196)(197)(198)(199)(200)(201). Human salivary glands are reactive to 1 -AT in ductal segments but unreactive to -ACT in glandular components (202).…”

Section: Lysozyme Lactoferrin 1 -Antichymotrypsin and 1 -Antitrypsinmentioning

confidence: 99%

Antimicrobial Peptides in Saliva and Salivary Glands: Their Roles in the Oral Defense System

et al. 2006

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Presence of α1-Antichymotrypsin and α1-Antitrypsin in Haematopoietic and Lymphoid Tissue Cells as Revealed by the Immunoperoxidase Method

Cited by 57 publications

References 16 publications

Acute Myocardial Infarction and Proinflammatory Gene Variants

Acute Myocardial Infarction and Proinflammatory Gene Variants

Polymorphism in the alpha1-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations

Antimicrobial Peptides in Saliva and Salivary Glands: Their Roles in the Oral Defense System

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