Presence of Vasoactive Intestinal Peptide Receptor in the Hen Hypothalamus.

Gonzales, Sylvia Mast; Kawashima, Mitsuo; Kamiyoshi, Michiharu; Tanaka, Katuhide; Ichinoe, Kenji

doi:10.1507/endocrj.42.179

Cited by 5 publications

(4 citation statements)

References 27 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results correspond well with VIP binding site studies in the avian hypothalamus and pituitary showing high levels of VIP receptor mRNA in the hypothalamus and are consistent with the function of VIP as a neuroendocrine factor or neurotransmitter [32,35]. They are also in accordance with recent studies, using Northern blot hybridization and quantitative reverse transcriptase-polymerase chain reaction analyses, which report that major VIP receptor gene expression was found within the avian hypothalamus and pituitary [31,39].…”

Section: Discussionsupporting

confidence: 92%

“…It has been suggested that a single VIP receptor is expressed and functions in nonmammalian species [31]. In birds, VIP receptors are present on the surface membranes of the anterior pituitary [32][33][34], the hypothalamus [35], the small intestine, and the granulosa cells [36]. VIP stimulation increases levels of intracellular cAMP in chicken pituitary cells [37] and in the hypothalamus [38].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

Chaiseha

Youngren

Halawani

2004

Biology of Reproduction

View full text Add to dashboard Cite

Vasoactive intestinal peptide (VIP) has been implicated in the regulation of avian reproductive activity and appears to act at the level of the hypothalamus and pituitary. This in situ hybridization histochemistry study describes the distribution of VIP receptor mRNA expression in the hypothalamus and the pituitary of reproductively active (laying) and quiescent (nonphotostimulated, incubating, and photorefractory) female turkeys and characterizes the differences observed in VIP receptor gene expression. VIP receptor mRNA, while expressed throughout the hypothalamus, was specifically expressed in areas known to contain GnRH-I neurons in the chicken, i.e., the lateral septum, medial preoptic area, anterior hypothalamus, and paraventricular nucleus. Significant differences in VIP receptor mRNA expression between different reproductive states was observed only within the infundibular nuclear complex. VIP receptor mRNA was markedly less in nonphotostimulated and photorefractory hens as compared with laying and incubating hens. The most dense VIP receptor mRNA was found in the anterior pituitary, where it was 2.4- and 3.0-fold greater in laying and incubating hens, respectively, as compared with that in nonphotostimulated ones. Hens that stopped incubating and became photorefractory displayed pituitary VIP receptor mRNA levels similar to those of nonphotostimulated birds. The changes in pituitary VIP receptor mRNA expression were positively correlated with known changes in pituitary prolactin (PRL) mRNA expression and PRL content and release. These findings indicate that the variations in PRL secretion observed across the turkey reproductive cycle are, in part, regulated by changes in VIP receptors at the pituitary level.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

Chaiseha

Youngren

Halawani

2004

Biology of Reproduction

View full text Add to dashboard Cite

show abstract

“…B max values for the binding of [ 125 I]cVIP and [ 125 I]PACAP have been obtained for chicken hypothalamus and chicken cortical cerebral membranes respectively. [ 125 I]cVIP has been shown to bind with 167 fmol/mg protein to chicken hypothalamic membranes [8]~1/3 of the B max for [ 125 I] PACAP in cortical cerebral membranes of the same species [9].…”

Section: Pac and Vpac Receptorsmentioning

confidence: 99%

“…Vasoactive intestinal peptide (VIP) [1] [2] and pituitary adenylate cyclase activating peptide (PACAP) [3] [4] activate three types of G-protein-coupled receptors (GPCR) which belong to the Class B receptor family (secretin/glucagon/VIP receptors) and have been intensively investigated [5]- [7] for their structure-activity relationships (SAR) and localization in peripheral tissues and CNS [8]- [11]. These PAC1, VPAC1 and VPAC2 receptors can be found in special regions of brain and spinal cord in densities potentially suitable for in vivo imaging with high affinity radiotracer ligands [9].…”

Section: Introductionmentioning

confidence: 99%

Potential PET Ligands for Imaging of Cerebral VPAC and PAC Receptors: Are Non-Peptide Small Molecules Superior to Peptide Compounds?

Pissarek¹

2015

WJNS

View full text Add to dashboard Cite

Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have been known for decades to mediate neuroendocrine and vasodilative actions via G-proteincoupled receptors of Class B. These are targets of imaging probes for positron emission tomography (PET) or single photon emission tomography (SPECT) in tumor diagnostics and tumor grading. However, they play only a subordinate role in the development of tracers for brain imaging. Difficulties in development of non-peptide ligands typical for cerebral receptors of PACAP and VIP are shared by all members of Class B receptor family. Essential landmarks have been confirmed for understanding of structural details of Class B receptor molecular signalling during the last five years. High relevance in the explanation of problems in ligand development for these receptors is admitted to the large N-terminal ectodomain markedly different from Class A receptor binding sites and poorly suitable as orthosteric binding sites for the most small-molecule compounds. The present study is focused on the recently available receptor ligands for PAC1, VPAC1 and VPAC2 receptors as well as potential small-molecule lead structures suitable for use in PET or SPECT. Recently, biaryl, cyanothiophene and pentanamide structures with affinities in nM-range have been proposed as non-peptide ligands at VPAC1 and VPAC2 receptors. However, most of these ligands have been classified as non-competitive related to the orthosteric binding site of endogenous peptide ligands of VPAC receptors. For PAC1 receptors have been identified hydrazide compounds for which an inhibitory and potentially competitive mechanism of receptor binding has been postulated based on molecular docking studies. M. Pissarek 365

show abstract

Molecular Cloning and Expression Analysis of the Turkey Vasoactive Intestinal Peptide Receptor

You

Hsu

Kim

et al. 2001

General and Comparative Endocrinology

View full text Add to dashboard Cite

Presence of Vasoactive Intestinal Peptide Receptor in the Hen Hypothalamus.

Abstract: These results suggest the presence of a VIP receptor in the hen hypothalamus.

Cited by 5 publications

References 27 publications

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

Potential PET Ligands for Imaging of Cerebral VPAC and PAC Receptors: Are Non-Peptide Small Molecules Superior to Peptide Compounds?

Molecular Cloning and Expression Analysis of the Turkey Vasoactive Intestinal Peptide Receptor

Contact Info

Product

Resources

About