Presence of type I and type II/IB receptors for adrenocorticosteroid hormones in the inner ear

Rarey, Kyle E.; Luttge, William G.

doi:10.1016/0378-5955(89)90013-0

Cited by 91 publications

(42 citation statements)

References 18 publications

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“…Glucocorticoid receptors at a high concentration have been found in both cochlea and vestibular tissues by means of in vitro binding studies using radiolabeled dexamethasone (24). Further immunohistochemical studies on glucocorticoid receptor distribution in the murine inner ear reveal that the highest expression of the receptor is seen in the type III fibrocytes of the spiral ligament.…”

Section: Glucocorticoid Receptormentioning

confidence: 95%

Transcriptional Factors in the Cochlea Within the Inner Ear

et al. 2005

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Abstract. Differential regulation of gene expression by transcription factors is widely viewed as one of the principal mechanisms guiding development. Although numerous DNA binding proteins have been identified in various tissues, the role of individual transcription factors in the differentiation of specific cell groups, such as those populating the inner ear, is just beginning to be elucidated. It is known that transcription factors are induced in response to many signals that lead to cell growth, differentiation, inflammatory responses, the regulation of apoptosis, and neoplastic transformation. There are various transcription factors in the cochlea of the inner ear. These include activator protein-1 and nuclear factor-kappa B, glucocorticoid receptor, and so on. Based on recent reports and our investigation, in this article we review possible functions and expression of these transcription factors.

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Section: Glucocorticoid Receptormentioning

confidence: 95%

Transcriptional Factors in the Cochlea Within the Inner Ear

et al. 2005

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“…Corticosteroid receptors have been reported in several inner ear epithelia (Rarey and Luttge, 1989;Pitovski et al, 1993a). The mineralocorticoid signaling system has perhaps received the most attention with respect to regulation of epithelial Na ϩ transport genes in the kidney and other tissues (Bhargava and Pearce, 2004).…”

Section: Regulation By Corticosteroid Receptorsmentioning

confidence: 99%

Endolymphatic Sodium Homeostasis by Extramacular Epithelium of the Saccule

Kim

Marcus²

2009

J. Neurosci.

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The saccule is a vestibular sensory organ that depends upon regulation of its luminal fluid, endolymph, for normal transduction of linear acceleration into afferent neural transmission. Previous studies suggested that endolymph in the saccule was merely derived from cochlear endolymph. We developed and used a preparation of isolated mouse saccule to measure transepithelial currents from the extramacular epithelium with a current density probe. The direction and pharmacology of transepithelial current was consistent with Na ϩ absorption by the epithelial Na ϩ channel (ENaC) and was blocked by the ENaC-specific inhibitors benzamil and amiloride. Involvement of Na

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“…In the present study group B patients are given Intratympanic Methyl Prednisolone as a primary therapy. 7 Both adrenocorticoid and glucocorticoid receptors are found in the inner ear, though the precise mechanism of action is not known. 8 The main role of steroids is to protect the cochlea from inflammatory mediators released like TNA-a and NFK b.…”

Section: Discussion: Sudden Sensorineural Hearing Loss Is One Of the mentioning

confidence: 99%

A Clinical Study on Intratympanic Methyl Prednisolone as Primary and Rescue Therapies Versus Oral Prednisolone in the Treatment of Ssnhl: A Study on 90 Patients

A¹,

Ravishankar²,

S³

et al. 2015

jemds

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INTRODUCTION:Sudden Hearing Loss is a real emergency requiring a fixed protocol in every hospital to help the patient recover his lost hearing ability. Diagnostic tools including pure tone and speech audiometry, Hematological tests and MRI scan will guide the physician to identify the etiology of deafness to a certain extent, but in majority of the patients it is difficult. Oral steroid therapy with Prednisolone or Methyl Prednisolone over a period of 19 days is the most common choice. It also seems to be the best treatment option. Recently intratympanic steroids have become an attractive choice either as a primary therapy or as an adjuvant therapy, in patients showing no or little improvement with oral steroids. It is also useful in patients in whom steroids are contraindicated. OBJECTIVE: To observe and analyze the result of improvement in hearing following Intratympanic steroids used as a primary treatment and rescue therapy versus results in the patients on oral steroids alone taken as a control group; To evolve a treatment protocol in the management of SSNHL in our Hospital. MATERIALS AND METHODS: In this prospective study 90 patients are divided into three groups and the effect of Oral Prednisolone therapy on improving hearing is compared with primary and rescue therapy with Intratympanic steroid injections. Pre and post therapy audiograms of pure tone (PTA) and speech audiometry (SRT) of the three groups are analyzed to formulate a meaningful solution. RESULTS: Intratympanic steroids as a primary therapy showed effective recovery of hearing, observed by reduction in PTA of more than 15dB and improved SRT scoring of more than 15%. This study showed statistical significance when compared with systemic steroids therapy and failed systemic steroid therapy (less than expected P value <0.05) Intratympanic injections as a rescue therapy also showed recovery of hearing with fall in PTA to <15dB and improved SRT scoring >15%. CONCLUSIONS: Four injections of Steroids into the middle ear used as primary or rescue therapies, improved hearing thresholds as recorded on pure tone average and speech discrimination. The additional advantage of avoiding systemic side effects is established once again in this study.

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Presence of type I and type II/IB receptors for adrenocorticosteroid hormones in the inner ear

Cited by 91 publications

References 18 publications

Transcriptional Factors in the Cochlea Within the Inner Ear

Transcriptional Factors in the Cochlea Within the Inner Ear

Endolymphatic Sodium Homeostasis by Extramacular Epithelium of the Saccule

A Clinical Study on Intratympanic Methyl Prednisolone as Primary and Rescue Therapies Versus Oral Prednisolone in the Treatment of Ssnhl: A Study on 90 Patients

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