Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer

Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

“…In agreement with results of a recently published study in vulvar carcinoma [23], we did not find an association between the number of T-lymphocytes and survival of vulvar carcinoma patients. This result is in contrast with studies previously performed in endometrial [9,11], ovarian [10,30] and cervical carcinoma [31]. In this study, vulvar carcinomas with infiltration depth of >5 mm were associated with a high number of CD8 + T-lymphocytes and a Younger patients with vulvar carcinoma more frequently showed downregulation of HLA-A.…”

“…one whole core consisting of 100% tumor tissue) (Figs. 1A and B) [9,10]. IDO expression was assessed according to a semi-quantitative scale which is based on the extent and intensity of the staining [29].…”

“…Recognition of "non-self" by CTLs can only take place when antigenic peptides (which are derived from digested proteins and broken down in the proteasome of the cell and transported to the cell surface) are presented by the human leukocyte antigen (HLA) class I present at the cell surface of every nucleated cell. The importance of CTL as part of anti-tumor response was emphasized by studies in several cancers demonstrating an association between a high number of tumor-infiltrating CD8 + T-lymphocytes (CTL) and increased survival [9][10][11][12][13][14]. However, cancer cells can develop several strategies to escape eradication by the immune system [15].…”

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

“…In the end, we reviewed 58 studies encompassing 16 different cancer types (Table 1), including bladder (19), breast (21)(22)(23)(24)(25)(26)(27)(28), cervical (29,30), colorectal (12,(31)(32)(33)(34)(35)(36)(37)(38)(39), endometrial (40)(41)(42), gastric (14,(43)(44)(45)(46), head and neck (47), hepatocellular (48)(49)(50)(51)(52), lung (53,54), melanoma (55)(56)(57)(58), mesothelial (59), oral (4,(60)(61)(62)(63), ovarian (2,3,…”

Immune Checkpoint Inhibitors in Gynecological Cancers: Update of Literature and Perspectives of Clinical Research

“…de Jong et al (82) assessed CD8 + TILs and T-reg cells on paraffin-embedded tissue specimens from 368 patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I-IV EC. A high number of CD8 + T cells and/or a high CD8 + T cell /T-reg cell ratio correlated with early stage, low histologic grade, superficial myometrial invasion, lack of LVSI, negative lymph nodes and absence of distant metastases at the time of diagnosis.…”