Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma

Willemsen, Marcella; Tio, Darryl; Krebbers, Gabrielle; Kasiem, Fazira R; Jaspars, Elisabeth H; Matos, Tiago R.; Bekkenk, Marcel W.; Bakker, Walbert J.; Luiten, Rosalie M.

doi:10.1097/dad.0000000000002184

Cited by 6 publications

(4 citation statements)

References 30 publications

(35 reference statements)

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“…Melanoma-specific Trm cells can persist in the skin for a long time, and the CD8 + T cells of melanoma patients exhibit a long-term response to immunotherapy for more than one year. In particular, CD103 + CD8 + Trm cells can play a key role in antitumor immunity and effectively prevent the reattack of melanoma cells ( 89 ). In other diseases, CD8 + Tcm cells can migrate into the skin, where they are the first line of defense against subsequent infection after skin vaccinia virus infection has subsided ( 106 ).…”

Section: Discussionmentioning

confidence: 99%

“…Among these critical factors, the expression of CD103 is required for the formation of CD8 + Trm cells in the skin. CD103 + CD8 + Trm cells play a solid protective role, and the long-term response of melanoma CD8 + T cells to immunotherapy for more than one year can effectively prevent the reattack of melanoma; thus, CD103-dependent Trm cells play a crucial role in antitumor immunity ( 89 ). Another TCR sequence analysis revealed the coexistence of Trm cells in the skin and Tem cells in the blood.…”

Section: Trm Cell Phenotypes In Skin Diseasesmentioning

confidence: 99%

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Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review

Liu,

Wang,

2024

Front. Immunol.

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Skin tissue-resident memory T (Trm) cells are produced by antigenic stimulation and remain in the skin for a long time without entering the peripheral circulation. In the healthy state Trm cells can play a patrolling and surveillance role, but in the disease state Trm cells differentiate into various phenotypes associated with different diseases, exhibit different localizations, and consequently have local protective or pathogenic roles, such as disease recurrence in vitiligo and maintenance of immune homeostasis in melanoma. The most common surface marker of Trm cells is CD69/CD103. However, the plasticity of tissue-resident memory T cells after colonization remains somewhat uncertain. This ambiguity is largely due to the variation in the functionality and ultimate destination of Trm cells produced from memory cells differentiated from diverse precursors. Notably, the presence of Trm cells is not stationary across numerous non-lymphoid tissues, most notably in the skin. These cells may reenter the blood and distant tissue sites during the recall response, revealing the recycling and migration potential of the Trm cell progeny. This review focuses on the origin and function of skin Trm cells, and provides new insights into the role of skin Trm cells in the treatment of autoimmune skin diseases, infectious skin diseases, and tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Trm Cell Phenotypes In Skin Diseasesmentioning

confidence: 99%

Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review

Liu,

Wang,

2024

Front. Immunol.

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“…In the melanoma tumor microenvironment, abundant CD69 + T cells are found. 151 Importantly, CD69 + CD103 + tumor‐resident CD8 + T cells and local IL‐15 production were associated with response to immune checkpoint inhibitors. 139 CD8 + T RM exhibit high levels of PD‐1, CTLA‐4, and LAG‐3, and a recent review is dedicated to their crucial role in melanoma immunotherapy.…”

Section: Functions Of Skin T Rmmentioning

confidence: 99%

“…Nonmalignant melanocytic lesions contain increased numbers of CD103 + CD8 + T RM . In the melanoma tumor microenvironment, abundant CD69 + T cells are found 151 . Importantly, CD69 + CD103 + tumor‐resident CD8 + T cells and local IL‐15 production were associated with response to immune checkpoint inhibitors 139 .…”

Section: Functions Of Skin Trmmentioning

confidence: 99%

Functional heterogeneity of human skin‐resident memory T cells in health and disease

Strobl

Haniffa

2023

Immunological Reviews

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Summary The human skin is populated by a diverse pool of memory T cells, which can act rapidly in response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have been implicated in range of allergic, autoimmune and inflammatory skin diseases. Clonal expansion of cells with TRM properties is also known to contribute to cutaneous T‐cell lymphoma. Here, we review the heterogeneous phenotypes, transcriptional programs, and effector functions of skin TRM. We summarize recent studies on TRM formation, longevity, plasticity, and retrograde migration and contextualize the findings to skin TRM and their role in maintaining skin homeostasis and altered functions in skin disease.

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In the right place at the right time: tissue-resident memory T cells in immunity to cancer

Ramirez

Mohamed

Huang

et al. 2023

Current Opinion in Immunology

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Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 6 publications

References 30 publications

Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review

Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review

Functional heterogeneity of human skin‐resident memory T cells in health and disease

In the right place at the right time: tissue-resident memory T cells in immunity to cancer

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