Presence of <scp>SCF</scp>/<scp>CXCL</scp>12 double‐positive large blast‐like cells at the site of cutaneous extramedullary haematopoiesis

Kogame, Toshiaki; Hirata, Masahiro; Kataoka, Tatsuki R.; Seidel, Judith A.; Ueshima, Chiyuki; Matsui, Miho; Nomura, Takashi; Kabashima, Kenji

doi:10.1111/jdv.15068

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…However, we could not have access to seven papers written in Japanese that were cited in one record 19 . Therefore, our study included 43 papers, describing 47 patients 6,9,19–59 …”

Section: Resultsmentioning

confidence: 99%

Cutaneous involvement in Ph‐negative myeloproliferative neoplasms: from extramedullary hematopoiesis to myeloid metastasis with histiocytic differentiation. A systematic review of the literature

Bonometti

2023

Int J Dermatology

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Myeloid neoplasms may metastasize to the skin, presenting a wide range of clinical‐pathological features that often lead to a reduction in patients' survival. The presentation varies depending on the category of myeloid neoplasm and its prognostic significance. The literature has specifically focused on the features of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and chronic myelomonocytic leukemia (CMML). In this article, we aimed to uncover the peculiarities of clonal skin proliferations in the course of Ph‐negative myeloproliferative neoplasms (MPNs). We conducted a systematic review and statistical analysis of the literature data. MPN patients mainly exhibited cutaneous extramedullary hematopoiesis, while a minority displayed cutaneous histiocytic lesions. Furthermore, these patients showed lower survival rates compared to the median survival of MPN patients, especially when calculating survival from the appearance of cutaneous lesions. Our work highlights, for the first time, the prognostic relevance and histological heterogeneity of cutaneous lesions in MPN. Moreover, it emphasizes the importance of dermatological and histological examinations when cutaneous lesions are present.

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“…However, we could not have access to seven papers written in Japanese that were cited in one record 19 . Therefore, our study included 43 papers, describing 47 patients 6,9,19–59 …”

Section: Resultsmentioning

confidence: 99%

Cutaneous involvement in Ph‐negative myeloproliferative neoplasms: from extramedullary hematopoiesis to myeloid metastasis with histiocytic differentiation. A systematic review of the literature

Bonometti

2023

Int J Dermatology

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“…2 Some cutaneous EMH cases accompanied by primary myelofibrosis, agnogenic myeloid metaplasia and polycythemia vera have been reported. [1][2][3][4][5][6] We treated an EMH patient with cutaneous EMH whose cutaneous lesions might suggest the aggravation of myelofibrosis. To our knowledge, this is the first reported case of a patient with secondary myelofibrosis who developed cutaneous EMH.…”

Section: Doi: 101111/jdv16977mentioning

confidence: 99%

“…[1][2][3] EMH is usually observed in the liver, spleen and lymph nodes in myeloproliferative disorders, such as idiopathic myelofibrosis (MF), polycythemia vera and chronic myelogenous leukaemia. [1][2][3][4][5][6] Cutaneous EMH is a very rare form of EMH, especially in adults. 2 Some cutaneous EMH cases accompanied by primary myelofibrosis, agnogenic myeloid metaplasia and polycythemia vera have been reported.…”

Section: Doi: 101111/jdv16977mentioning

confidence: 99%

“…5 Any organ of the body can be affected by LCH; however, in children, most frequently bones (80%), followed by skin (33%) and pituitary gland (25%), spleen, hematopoietic, lung and liver are predominant locations of manifestation. 6 The lung is the main affected side in adults. In >80% of cases of L-group histiocytoses genes of the MAPK pathway are involved; however, mutations were absent in our patient.…”

Section: Langerhans Cell Histiocytosis Mimicking Prurigo Nodularismentioning

confidence: 99%

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Cutaneous extramedullary hematopoiesis in a patient with secondary myelofibrosis due to MPL gene mutation

Murase

Takeichi

Tanahashi

et al. 2020

Acad Dermatol Venereol

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“…Circulating HSCs may home to the skin by a similar mechanism. One report of an adult with nodular CEMH explored the stromal environment of the nodule by immunofluorescence, observing blast‐like SCF+/CXCL12+ cells in the stroma . The role of CAR and CXCL12 in maintenance of the HSC bone marrow niche and HSC mobilization in cutaneous and non‐cutaneous EMH remains to be investigated.…”

Section: Pathophysiologymentioning

confidence: 99%

Cutaneous extramedullary haematopoiesis: Implications in human disease and treatment

Khalil

Gru

Saavedra

2019

Experimental Dermatology

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The skin and bone marrow are two of the most dynamic organ systems of the human body. While the skin is only transiently involved in haematopoiesis in utero, cutaneous extramedullary haematopoiesis (CEMH) has been appreciated in various neonatal and adult diseases. The mechanism by which CEMH occurs remains poorly understood, but may be associated with the plasticity of blood and skin tissues. Extensive studies have documented expansion and differentiation of haematopoietic lineages from cutaneous tissues and vice versa. This review will discuss CEMH, potential mechanisms and laboratory findings that shed light on the interaction between both tissues. Further, we will discuss the implications of understanding the role of the skin in haematopoiesis, including the potential therapeutic function of manipulating either organ system in the treatment of pathologic processes in the other.

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Presence of SCF/CXCL12 double‐positive large blast‐like cells at the site of cutaneous extramedullary haematopoiesis

Cited by 4 publications

References 8 publications

Cutaneous involvement in Ph‐negative myeloproliferative neoplasms: from extramedullary hematopoiesis to myeloid metastasis with histiocytic differentiation. A systematic review of the literature

Cutaneous involvement in Ph‐negative myeloproliferative neoplasms: from extramedullary hematopoiesis to myeloid metastasis with histiocytic differentiation. A systematic review of the literature

Cutaneous extramedullary hematopoiesis in a patient with secondary myelofibrosis due to MPL gene mutation

Cutaneous extramedullary haematopoiesis: Implications in human disease and treatment

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