Presence of rRNA-like regions in Genbank viral sequences

Evseev, Peter; Landysheva, Yana G.; Landyshev, Nikolay N.; Игнатов, А Н

doi:10.1109/csgb53040.2021.9496035

Cited by 1 publication

(2 citation statements)

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“…RNAi is the process of suppressing gene expression at the stage of transcription and translation using a double-stranded RNA copy (most often more than 200 bp in length) of the corresponding gene (Tomoyasu, 2008;Svoboda, 2020). At the early stages of RNA interference, the doublestranded RNA fragment is cut by the enzyme dicer (RNase III) into shorter fragments, small interfering RNAs (siRNAs) 20 (Pallis et al, 2023;GreenLight Biosciences, 2024). Calantha™ ledprona, is a new class of insecticide -Group 35.…”

Section: Rna Biocontrolsmentioning

confidence: 99%

“…Bioinformatics studies indicate that hijacking of host genes by viruses is common (Cerio et al, 2010). Indeed, during coevolution, DNA viruses could not miss the opportunity to hijack rRNA genes (Evseev et al, 2021) as key players in metabolism, since rRNA makes up four fifths of all RNA in a cell (Deng et al, 2022), and more than 60% of all energy is spent on the production and maintenance of ribosomes (Szaflarski et al, 2022). Most DNA viruses replicate in nucleus and most viruses interact with the nucleolus that plays a major role in virus life and assembly of ribosomes (Salvetti and Greco, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Oligonucleotide insecticides (contact unmodified antisense DNA biotechnology) and RNA biocontrols (double-stranded RNA technology): newly born fraternal twins in plant protection

Oberemok,

Gal’chinsky

2024

Preprint

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The rapid development of molecular genetics, methods of synthesis of nucleic acids, and bioinformatics have created fundamentally new opportunities in plant protection. DNA and RNA have become active ingredients of insecticides, going beyond their usual role as carriers of hereditary information. Now nucleic acids are increasingly acting as active tools for insect pest control using the mechanisms of DNA containment (oligonucleotide insecticides, contact unmodified antisense DNA (CUAD) biotechnology) and RNA interference (RNA biocontrols, double-stranded RNA biotechnology). Partial understanding of how antisense DNA oligonucleotides might work began in the late 1970s of XX century and for a long time (until the beginning of the XXI century) these biomolecules had not been implemented in plant protection in the form of any biotechnology based on unmodified or modified DNA fragments. RNA interference was discovered in the late 90s of XX century and also went through quite a long path of development in plant protection before the first encouraging results of its application as insecticides appeared. Both, CUAD biotechnology and double-stranded RNA technology aim to inactivate the expression of genes of insect pests using antisense DNA and double-stranded RNA that help trigger degradation of the target RNA. As two new classes of the next-generation insecticides, these products are supposed to have long operational life, low carbon footprint, high selectivity in action and rapid biodegradation in ecosystems. To date, antisense CUAD biotechnology shows the best results on sap-sucking insects while double-stranded RNA technology shows the best insecticidal potential on beetles from Tenebrionidae and Chrysomelidae families. With a high probability, oligonucleotide insecticides and RNA biocontrols, will be effective against certain groups of insects and can complement each other in complex formulations for control of wide range of pests.

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